Results 201 to 210 of about 13,171,622 (345)

De Novo Design and Directed Evolution Refinement of Mirror‐Image Protein Binders Targeting Interleukin‐4

Advanced Science, EarlyView.
This study presents the de novo design and directed evolution of a mirror‐image D‐protein inhibitor targeting human interleukin‐4 (IL‐4). The engineered molecule exhibits nanomolar binding affinity for IL‐4 and effectively inhibits IL‐4–mediated signaling.
Liqing Xu, Yuxiang Ren, Tongyue Wang, Hongyong Li, Yue Yao, Lei Liu, Ke Sun, Peilong Lu   +7 more
wiley   +1 more source

FEM1B enhances TRAIL-induced apoptosis in T lymphocytes and monocytes. [PDF]

FEBS Open Bio
Yang C, Yu W, Dang C, Zhang J, Lu J, Xue J.   +5 more
europepmc   +1 more source

Understanding and Overcoming Antibody‐Drug Conjugate Resistance: Biological Mechanisms and Emerging Analytical Frameworks in Breast Cancer

Advanced Science, EarlyView.
Antibody–drug conjugates (ADCs) transform breast cancer therapy, yet resistance limits their durability. Emerging evidence reveals that ADC failure is not solely tumor‐intrinsic but shaped by dynamic tumor–microenvironment interactions that alter drug delivery, processing, and response.
Minji Seo, Jangsoon Lee, Naoto T. Ueno
wiley   +1 more source

Differences and significance of macrophage subtypes and regulatory T lymphocytes in the expression of interstitial fibrosis in diabetic nephropathy at different stages. [PDF]

BMC Nephrol
Huang J, Cai X, Yao X, Shen J, Wu H, Fang J, Zhu B, Wang H.   +7 more
europepmc   +1 more source

Prospective identification of neoantigen-specific lymphocytes in the peripheral blood of melanoma patients

Nature Medicine, 2016
A. Gros, M. Parkhurst, E. Tran, A. Pasetto, P. Robbins, Sadia Ilyas, Todd D Prickett, J. Gartner, J. Crystal, Ilana M. Roberts, Kasia Trebska-Mcgowan, J. Wunderlich, J. Yang, S. Rosenberg   +13 more
semanticscholar   +1 more source

A Nanoparticle‐Integrated Complete Manufacturing Pipeline of Chemically Engineered Exosomes

Advanced Science, EarlyView.
We report a novel manufacture technology of chemically engineered exosomes. The four steps of manufacturing, i.e., biogenesis, loading, isolation, and storage, are integrated by the use of a nanoparticle. The manufacture technology incorporates three innovative components, i.e., a new nano‐bio effect, a new composite nanoparticle, and a new isolation ...
Xiaowei Wen, Zixing Xu, Zerun Hao, Yanming Chen, Kai Xie, Haofan Yin, Xueying Wang, Jie Min, Sihan Sun, Baiding Chen, Chengxiu Ling, Mingming Xu, Yizhao Chen, Gang Ruan   +13 more
wiley   +1 more source

Beyond the Th2 paradigm: CD4+ cytotoxic T lymphocytes as key drivers of tissue damage and fibrosis in IgG4-related disease. [PDF]

Front Immunol
Yi J, Jia L, Mao T, Li Z.
europepmc   +1 more source

Targeting Peptostreptococcus anaerobius with an Iron‐Based Nanozyme Reverses Ferroptosis Resistance and Enhances Antitumor Immunity in Colorectal Cancer

Advanced Science, EarlyView.
An iron‐based nanozyme selectively eliminates intratumoral P. anaerobius while catalytically generating ROS to induce ferroptosis, synergistically suppressing colorectal cancer growth and activating anti‐tumor immunity through immunogenic cell death. ABSTRACT The intratumoral microbiota is a critical determinant of therapeutic outcomes in colorectal ...
Yinghao Cao, Jun Wang, Hanwenchen Wang, Xiang Sun, Fang Fang, Shiying Li, Jianping Liu, Changrong Shi, Pengyuan Qi, Jianhua Zou, Xiaoyuan Chen, Kailin Cai   +11 more
wiley   +1 more source

Neuroinflammation in neurodegenerative diseases: Focusing on the mediation of T lymphocytes. [PDF]

Neural Regen Res
Li K, Chen R, Wang R, Fan W, Zhao N, Yang Z, Yan J.   +6 more
europepmc   +1 more source

Cytolytic T Lymphocyte Clones

Immunobiology, 1982
H R, MacDonald, R P, Sekaly, O, Kanagawa, N, Thiernesse, C, Taswell, J C, Cerottini, A, Weiss, A L, Glasebrook, H D, Engers, A, Kelso, K T, Brunner, C, Bron   +11 more
openaire   +2 more sources