Equine herpesvirus 1 bridles T lymphocytes to reach its target organs [PDF]
Equine herpesvirus 1 (EHV1) replicates in the respiratory epithelium and disseminates through the body via a cell-associated viremia in leukocytes, despite the presence of neutralizing antibodies. "Hijacked" leukocytes, previously identified as monocytic
Azab, Walid+7 more
core +1 more source
"Proliferation of cytotoxic and activated T cells during acute Epstein-Barr virus induced Infectious Mononucleosis " [PDF]
The immune responses that develop following Epstien-Barr Virus (EBV) infection are complex and involve both humoral and to a greater extent cell-mediated immune mechanisms. To evaluate the immune response, flow cytometric analysis of the peripheral blood
Mansoori SD, Shahgasempour S
doaj +2 more sources
Immunomagnetic t-lymphocyte depletion (ITLD) of rat bone marrow using OX-19 monoclonal antibody [PDF]
Graft versus host disease (GVHD) may be abrogated and host survival prolonged by in vitro depletion of T lymphocytes from bone marrow (BM) prior to allotransplantation. Using a mouse anti-rat pan T-lymphocyte monoclonal antibody (0×19) bound to monosized,
A. Pascualone+30 more
core +1 more source
CD4-helper-independent antiviral function of CD8-positive memory T lymphocytes derived from latently infected donors [PDF]
The ability of memory T lymphocytes derived from latently infected mice to control murine cytomegalovirus disease in the immunocompromised host was studied by adoptive transfer experiments.
Jonjic, Stipan+4 more
core +1 more source
Immune networks: multi-tasking capabilities near saturation [PDF]
Pattern-diluted associative networks were introduced recently as models for the immune system, with nodes representing T-lymphocytes and stored patterns representing signalling protocols between T- and B-lymphocytes. It was shown earlier that in the regime of extreme pattern dilution, a system with $N_T$ T-lymphocytes can manage a number $N_B!=!\order ...
arxiv +1 more source
Immunology and immunotherapy in the complex treatment of malignant tumors
Immuno-oncology is a rapidly developing field in medicine. Drug combination therapies have already been studied in many clinical trials of different types of tumours. In recent years, a checkpoint inhibition therapy with monoclonal antibodies that target
V. F. Semiglazov+14 more
doaj +1 more source
Failure in generating hemopoietic stem cells is the primary cause of death from cytomegalovirus disease in the immunocompromised host [PDF]
We have shown in a murine model system for cytomegalovirus (CMV) disease in the immunocompromised host that CMV infection interferes with the earliest detectable step in hemopoiesis, the generation of the stem cell CFU-S-I, and thereby prevents the ...
Busch, Friedrich W.+4 more
core +2 more sources
Signaling and Function of Interleukin-2 in T Lymphocytes.
The discovery of interleukin-2 (IL-2) changed the molecular understanding of how the immune system is controlled. IL-2 is a pleiotropic cytokine, and dissecting the signaling pathways that allow IL-2 to control the differentiation and homeostasis of both
S. Ross, D. Cantrell
semanticscholar +1 more source
Expression of CXCR4 on feline peripheral blood mononuclear cells: effect of feline immunodeficiency virus infection. [PDF]
CXCR4 expression on feline peripheral blood mononuclear cells (PBMC) was analyzed. While monocytes and B lymphocytes expressed CXCR4, no CXCR4 was detected on T lymphocytes, in stark contrast to the expression pattern on T lymphocytes from humans.
Cannon, C.A., Hosie, M.J., Willett, B.J.
core +2 more sources
Significance None of the single-cell RNA sequencing (scRNA-seq) studies published so far convincingly identified human γδ T lymphocytes despite their anticancer functions.
Gabriele Pizzolato+18 more
semanticscholar +1 more source