Results 121 to 130 of about 3,611,259 (291)

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Stochastic-Based Pattern Recognition Analysis [PDF]

In this work we review the basic principles of stochastic logic and propose its application to probabilistic-based pattern-recognition analysis. The proposed technique is intrinsically a parallel comparison of input data to various pre-stored categories ...
Rossello, J.L., Morro, A., Canals, V.
core   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Study on the correlation between dietary patterns and bone health among rural elderly people in Qingdao

Frontiers in Nutrition
ObjectiveTo evaluate the relationship between dietary patterns and bone health in the elderly, and to guide the elderly to establish a reasonable dietary pattern and improve bone health.MethodsThis cross-sectional study included 544 elderly individuals ...
Haoran Chang, Wenchao Han, Jiafei Li, Dazhi Jiao, Fangyu Liu, Tianlin Gao, Wenjing Zhu, Jianbao Gong   +7 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Modeling of Ship Sailing Patterns in Maluku to Support the Sea Highway

International Journal of Technology
The low level of the ships' load factor (LF) in the Maluku archipelago region can be attributed to the lack of compatibility between ship loads and the available cargo potential in the region.
Marcus Tukan, Hanaa Abdelaty Hasan Esmail, Hozairi, Billy Camerling, Syariful Alim, Esther Sanda Manapa, Pieter Berhitu   +6 more
doaj   +1 more source

Spatial Point Pattern Analysis and Industry Concentration [PDF]

Traditional measures of spatial industry concentration are restricted to given areal units. They do not make allowance for the fact that concentration may be differently pronounced at various geographical levels. Methods of spatial point pattern analysis
Hans-Friedrich Eckey, Jørgen Lauridsen, Reinhold Kosfeld   +2 more
core  

Discriminative video pattern search for efficient action detection

, 2011
Actions are spatiotemporal patterns. Similar to the sliding window-based object detection, action detection finds the reoccurrences of such spatiotemporal patterns through pattern matching, by handling cluttered and dynamic backgrounds and other types of
null Ying Wu, null Zicheng Liu, Wu, Ying, Liu, Zicheng, null Junsong Yuan, Yuan, Junsong   +5 more
core   +1 more source