Results 131 to 140 of about 33,656,568 (290)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
, 1919 Pattern No. 4591: Two-piece hobble skirt opens to the left and is trimmed at the lower edge with buttons. Pattern No. 4595: Two-piece hobble skirt opens to the left and is trimmed with stitching.
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FEBS Letters, EarlyView.Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani +3 more
wiley +1 more source
, 1919 Pattern No. 4660: "Two-piece plaited skirt with simulated panel effect." "Separate girdle is buttoned with two buttons at the center front." Pattern No.
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FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
, 1920 Pattern No. 4472: Coat with wide cuffs and collar, kimono-style sleeves, and an "inverted plait at either side, from the waistline to the lower edge." "Front sections button over the back section" under the arms.
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Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
, 1919 Pattern No. 4831: Collared blouse with front section that extends past the waist and is finished at the bottom with embroidery. Attached belt is finished with buttons, and darts along the bust line are finished with embroidered arrows. Peplum is "laid in
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Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Frock with Eton blouse and draped skirt, 1919
, 1919 Pattern No. 4735: Curved Eton blouse with a slashed front to simulate a panel vest. Shirtwaist with "crushed girdle" is trimmed with buttons. Sleeves "extend slightly below the elbow and are finished with flared cuffs." Skirt is draped with the right ...
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