Results 141 to 150 of about 33,656,568 (290)
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
, 1919 Pattern No. 4644: "Fullness of the cape is gathered to a shallow yoke under a deep collar." Cape is slashed at both sides to accommodate the narrow belt which ties at the front.
Vogue Pattern Service
core +1 more source
, 1917 Pattern No. 3721: Dress with double collar, and sleeves that are "gathered to straight cuffs rolled back at the wrists and faced." Both the collars and cuff facings are of a contrasting material. Neckline is fastened with two button closures. Wide girdle
Vogue Pattern Service
core
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
, 1919 Pattern No. 4788: Shirtwaist with a round neckline, girdle that ties in the back, and "transparent modesty gathered by a ribbon." Neckline and short sleeves trimmed with metal bead fringe.
Vogue Pattern Service
core
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
, 1917 Pattern No. 3805: Shirtwaist with a rolled collar faced in wide lace and a square-necked vest with wide lace along the upper half. Sleeves are "cut with a shaped cap to which is shirred the lower section of the sleeve, which is finished by a tight ...
Vogue Pattern Service
core
Discerning protein pools by selective staining with self‐labeling tags
FEBS Letters, EarlyView.Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley +1 more source
Coat-frock with waistcoat, 1919
, 1919 Pattern No. 4780: Waistcoat is trimmed along the edges with braid and down the center with a row of small buttons. Lower edge of the collared, belted blouse "turns up to form a deep cuff which is held in place at the center back with three buttons." Bell-
Vogue Pattern Service
core
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source