Results 91 to 100 of about 681,261 (380)

Protumorigenic activity of plasminogen activator inhibitor-1 through an antiapoptotic function.

Journal of the National Cancer Institute, 2012
BACKGROUND Plasminogen activator inhibitor-1 (PAI-1) is a protease inhibitor but is paradoxically associated with poor outcomes in cancer patients. However, the mechanisms of its effects on tumor cells have not been explored.
H. Fang, Veronica R. Placencio, Y. DeClerck   +2 more
semanticscholar   +1 more source

The Immune Microenvironment: New Therapeutic Implications in Organ Fibrosis

Advanced Science, EarlyView.
This review summarizes recent advances in understanding the immune microenvironment's role in fibrosis, focusing on phenotypic/functional alterations of immune cells and their dynamic interactions with other cellular constituents within tissues. The authors further explore therapeutic opportunities and challenges in targeting immune microenvironment ...
Xiangqi Chen, Chuan Wu, Fei Tang, Jingyue Zhou, Li Mo, Yanping Li, Jinhan He   +6 more
wiley   +1 more source

THE ACTIVATION OF PLASMINOGEN BY CHLOROFORM [PDF]

Journal of General Physiology, 1946
1. Treatment of serum with chloroform results in immediate inactivation of the protease inhibitor present. 2. Following a lag period of less than one to several days, proteolytic activity begins to appear in the chloroform-treated serum. Activity increases over a period of several days and then begins to diminish gradually.
openaire   +3 more sources

The Relationship Between Aldose Reductase and Isoxazole Derivatives: An In Vitro and In Silico Approach to Its Correlation With Diabetic Conditions

Biotechnology and Applied Biochemistry, EarlyView.
ABSTRACT Diabetes mellitus (DM), which can result in a number of problems such as cataracts, neuropathy, retinopathy, nephropathy, and several cardiovascular illnesses, continues to be a growing issue despite major advancements in treatment approaches.
Ahmet Esat Göner, Hatice Esra Duran
wiley   +1 more source

Stable cell line of T-SV40 immortalized human glomerular visceral epithelial cells [PDF]

, 1973
Stable cell line of T-SV40 immortalized human glomerular visceral epithelial cells. Human subcultures (third passage) of glomerular visceral epithelial cells (VEC) isolated from one month old kidney were successfully transfected by two recombinant ...
Adida, Colette, Delarue, Françoise, Feunteun, Jean, Hagege, Jacqueline, Lacave, Roger, Peraldi, Marie-Nëlle, Rondeau, Eric, Sraer, Jean-Daniel, Virone, Angela   +8 more
core   +1 more source

Anticoagulant activities of piperlonguminine in vitro and in vivo [PDF]

BMB Reports, 2013
Piperlonguminine (PL), an important component of Piperlongum fruits, is known to exhibit anti-hyperlipidemic, antiplateletand anti-melanogenic activities. Here, the anticoagulantactivities of PL were examined by monitoring activatedpartial-thromboplastin-
Wonhwa Lee, Hayoung Yoo, Sae-Kwang Ku, Jeong Ah Kim, Jong-Sup Bae   +4 more
doaj   +1 more source

Unveiling the complexity of cellular senescence in cancers: From mechanism to therapeutic opportunities

BMEMat, EarlyView.
This review highlights the complex roles of cellular senescence in cancer progression and suppression, discusses the mechanisms and regulatory pathways involved, and evaluates the efficacy of the “One‐Two punch” sequential treatment approach while addressing emerging challenges in this novel therapeutic strategy.
Qiuming Pan, Ye Zhu, Zhi Ye, Huayang Zhang, Junxi Wang, Guozhong Yi, Zhiyong Li, Rongyang Xu, Luyao Wang, Zhenzhen Wu, Songtao Qi, Guanglong Huang, Shanqiang Qu   +12 more
wiley   +1 more source

Iodixanol Has a Favourable Fibrinolytic Profile Compared to Iohexol in Cardiac Patients Undergoing Elective Angiography: A Double-Blind, Randomized, Parallel Group Study. [PDF]

PLoS ONE, 2016
BACKGROUND:There is no consensus and a limited evidence base for choice of contrast agents (CA) in angiography. This study evaluated the impact of iohexol and iodixanol CA on fibrinolytic factors (tissue plasminogen activator [t-PA] and plasminogen ...
Andrew T Treweeke, Benjamin H Maskrey, Kirsty Hickson, John H Miller, Stephen J Leslie, Ian L Megson   +5 more
doaj   +1 more source

Neutrophils in cancer: At the crucial crossroads of anti‐tumor and pro‐tumor

Cancer Communications, EarlyView.
Abstract Neutrophils are important components of the immune system and play a key role in defending against pathogenic infections and responding to inflammatory cues, including cancer. Their dysregulation indicates potential disease risk factors. However, their functional importance in disease progression has often been underestimated due to their ...
Wenpeng Cai, Tao Fan, Chu Xiao, Ziqin Deng, Yixiao Liu, Chunxiang Li, Jie He   +6 more
wiley   +1 more source

Sex Differences in rt-PA Utilization at Hospitals Treating Stroke: The National Inpatient Sample. [PDF]

, 2017
BACKGROUND AND PURPOSE: Sex and race disparities in recombinant tissue plasminogen activator (rt-PA) use have been reported. We sought to explore sex and race differences in the utilization of rt-PA at primary stroke centers (PSCs) compared to non-PSCs ...
Albright, Karen C, Boehme, Amelia K., Branas, Charles C., Carr, Brendan G., Elkind, Mitchell S V S.V., Kallan, Michael J., Kasner, Scott Eric, Mullen, Michael T.   +7 more
core   +2 more sources