Results 331 to 340 of about 681,261 (380)

Mechanisms of Plasminogen Activation by Mammalian Plasminogen Activators

Enzyme, 1988
Plasminogen activators convert the proenzyme plasminogen to the active serine protease plasmin by hydrolysis of the Arg560-Val561 peptide bond. Physiological plasminogen activation is however regulated by several additional molecular interactions resulting in fibrin-specific clot lysis.
H R Lijnen, D Collen
openaire   +2 more sources

Plasminogen/plasminogen activator and growth factor activation.

Ciba Foundation symposium, 1997
The plasminogen/plasminogen activator system is widely used in extracellular proteolysis. In this review the involvement of this system in tumour invasion, cell migration, growth factor presentation and inhibition of angiogenesis are discussed.
Rifkin, DB, Gleizes, PE, Harpel, J, Nunes, I, Munger, J, Mazzieri, R, Noguera, I   +6 more
openaire   +3 more sources

Plasminogen Activator and Plasminogen Activator Inhibitor Activities in a Reference Population

American Journal of Clinical Pathology, 1988
The influence of age, gender, and aspirin ingestion on plasma levels of tissue plasminogen activator (t-PA) and plasminogen activator inhibitor-1 (PAI-1) activities was studied in a reference population of 35 men and 35 women between the ages of 20 and 65 years.
Barbara M. Alving, Douglas B. Tang, Charles F. Barr, Chitra Krishnamurti   +3 more
openaire   +3 more sources

Plasminogen activation by tissue plasminogen activator in the presence of platelets

Thrombosis Research, 1988
Platelets were found to provide a surface for activation of plasminogen by the tissue-type plasminogen activator (t-PA) at an optimum concentration and to potentiate the generation of plasmin by the amidolytic method, fibrin lysis time and fibrin plate method.
Katsumi Deguchi, Shigeru Shirakawa
openaire   +3 more sources

Activation of Bovine Plasminogen by the Plasminogen Activator in Animal Tissue

Thrombosis and Haemostasis, 1960
Summary1. The activation of bovine plasminogen by means of the plasminogen activator from pig heart tissue has been studied on heated fibrin and on casein.2. Small, but varying, amounts of activator can be extracted from crude activator powder during the experiment and interfere therefore with estimations on normal, plasminogen containing fibrin.3. The
Takeshi Abe, Tage Astrup
openaire   +3 more sources

Evaluation of gingival crevicular fluid levels of tissue plasminogen activator, plasminogen activator inhibitor 2, matrix metalloproteinase-3 and interleukin 1-β in patients with different periodontal diseases.

Journal of Periodontal Research, 2015
OBJECTIVES The purpose of this study was to evaluate the gingival crevicular fluid levels of interleukin-1beta (IL-1β), matrix metalloproteinases-3 (MMP-3), tissue type plasminogen activator (t-PA) and plasminogen activator inhibitor 2 (PAI-2) in ...
Utku Toyman, G. Tüter, B. Kurtiş, E. Kıvrak, Ş. Bozkurt, Ayşegül Yücel, Muhittin A Serdar, Muhittin A Serdar   +7 more
semanticscholar   +1 more source

Tissue Activator of Plasminogen

Nature, 1964
SINCE Astrup and Permin1 reported that animal tissue cells contain an activator of plasminogen, various authors have confirmed their results, and comparisons of the activator content of different human2 and animal tissues3,4 have been published. Most authors have used whole tissue or aqueous tissue extracts and have estimated activity by the fibrin ...
Charles H. Lack, S. Yousuf Ali
openaire   +3 more sources

Platelets and Plasminogen Activation

Thrombosis and Haemostasis, 1995
Platelets serve as a site for assembly of the proteins of the plasminogen activator system. Once bound to the platelet surface, tissue-type plasminogen activator manifests enhanced catalytic activity. Plasmin, once formed, also binds to the platelets surface and, at low concentrations, renders the platelet dysfunctional by cleaving glycoprotein IIIa ...
Joseph Loscalzo, Ouimet H, Jane E. Freedman, Pasche B   +3 more
openaire   +3 more sources

Increased plasma levels of a rapid inhibitor of tissue plasminogen activator in young survivors of myocardial infarction.

New England Journal of Medicine, 1985
Certain risk factors for myocardial infarction have been linked with disturbances in fibrinolytic activity. The recent development in our laboratory of new sensitive and specific methods for determination of tissue plasminogen activator (t-PA) activity ...
A. Hamsten, B. Wiman, U. de Faire, M. Blombäck   +3 more
semanticscholar   +1 more source

Plasminogen activator / plasminogen activator inhibitors in ovarian physiology

Frontiers in Bioscience, 2004
The target extracellular matrix (ECM) degradation generated by plasminogen activator (PA) and regulated by plasminogen activator inhibitor (PAI) is an event that affects a wide variety of physiological and pathological processes in the ovary. Studies carried out over the past 25 years in a number of laboratories have elucidated some of the biochemical ...
openaire   +3 more sources