Results 351 to 360 of about 681,261 (380)

Zymographic Evaluation of Plasminogen Activators and Plasminogen Activator Inhibitors

2004
Publisher Summary The plasminogen activator/plasminogen activator inhibitor (PA/PAI) system is of considerable fundamental importance in elucidating the biochemical mechanisms of many physiological and patho-physiological processes. Although many techniques are available to assess the PA/PAI system, including ELISA and molecular assays, fibrin ...
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Activators of Plasminogen

1986
Fluidity of the blood without hemorrhage is maintained by the physiological equilibrium between the coagulation and fibrinolytic systems, each of which is comprised of intrinsic and extrinsic components. Activators of fibrinogen are compounds whose teleological function is the dissolution of fibrin clots which could potentially upset this hemostatic ...
Burton E. Sobel, Alice K. Robison
openaire   +2 more sources

Inhibitory effect of angiostatins on activity of the plasminogen/plasminogen activator system

Biochemistry (Moscow), 2009
Angiostatins, kringle-containing fragments of plasminogen, are potent inhibitors of angiogenesis. Effects of three angiostatin forms, K1-3, K1-4, and K1-4.5 (0-2 microM), on the rate of native Glu-plasminogen activation by its physiological activators in the absence or presence of soluble fibrin were investigated in vitro.
N. V. Prisyazhnaya, M.Y. Levashov, L.I. Mukhametova, D. A. Gulin, S.D. Varfolomeyev, K.B. Gershkovich, R.B. Aisina   +6 more
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The potentiating effect of platelet on plasminogen activation by tissue plasminogen activator

Thrombosis Research, 1985
A new role for platelets in fibrinolysis is proposed. Platelets (euglobulin from platelet rich plasma and from human platelet extract) may potentiate plasminogen activation by tissue plasminogen activator (tPA). The potentiating activity was detected by both chromogenic substrate and fibrin plate analysis. The fibrinolysis-potentiating substance in the
F. W. Dunn, Claudine Soria, Katsumi Deguchi, Jeannette Soria, Gérard Tobelem, Seikou Murashima, Shigeru Shirakawa   +6 more
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Free radical scavenger edaravone administration protects against tissue plasminogen activator induced oxidative stress and blood brain barrier damage.

Current Neurovascular Research, 2010
One of the therapeutics for acute cerebral ischemia is tissue plasminogen activator (t-PA). Using t-PA after 3 hour time window increases the chances of hemorrhage, involving multiple mechanisms.
V. Lukic-Panin, K. Deguchi, T. Yamashita, Jingwei Shang, Xuemei Zhang, Fengfeng Tian, Ning Liu, Hiromi Kawai, T. Matsuura, K. Abe   +9 more
semanticscholar   +1 more source

Differences in the activation rates of plasminogen by tissue plasminogen activator and urokinase

Thrombosis Research, 1987
The activation of a native form of plasminogen (Glu-plg) by tissue plasminogen activator(t-PA) was enhanced when the plasma was clotted by the addition of thrombin or thrombin plus Ca++. Cross-linking of fibrin in the clotted plasma did not inhibit the fibrin-associated enhancement of the activation of plasminogen by t-PA.
Masaru Cho, Kengo Shizume, Akikazu Takada, Yumiko Takada   +3 more
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Importance of the interaction between plasminogen and fibrin for plasminogen activation by tissue-type plasminogen activator

Thrombosis Research, 1984
The potentiating effect of fibrin monomer on plasminogen activation by tissue-type plasminogen activator is much more important with lys-plasminogen than with mini-plasminogen (which lacks the high affinity lysine-binding site important for binding to fibrin).
Claudine Soria, F. W. Dunn, Jeannette Soria, K. Deguchi, J.P. Caen, H.R. Lijnen, Gérard Tobelem   +6 more
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Lipoprotein(a) inhibition of plasminogen activation by tissue-type plasminogen activator

Thrombosis Research, 1990
Here experimental evidence is presented demonstrating that Lp(a) inhibits the activation of Pg by the physiologic activator tissue-type plasminogen activator (t-PA) bound to fibrinogen fragments. The competitive inhibition constant, Kie, of the Lp(a) inhibition is 22 nM, or 8.6 mg/dL which corresponds to normal plasma ...
Jay M. Edelberg, Mario Gonzalez-Gronow, Salvatore V. Pizzo   +2 more
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Immunohistochemical demonstration of the plasminogen activator system in human gingival tissues and gingival fibroblasts.

Journal of Periodontal Research, 2010
The relative distribution of urokinase-type plasminogen activator (u-PA), tissue-type plasminogen activator (t-PA), plasminogen activator inhibitor-1 (PAI-1) and plasminogen activator inhibitor-2 (PAI-2) was studied in cultured human gingival fibroblasts,
Yin Xiao, Clive L. Bunn, P. Bartold
semanticscholar   +1 more source

Kinetic studies of plasminogen activation by epithelial tissue plasminogen activator

Blood Coagulation & Fibrinolysis, 1990
Initial-rate kinetic studies of the activation of plasminogen by epithelial activator were performed in the absence and in the presence of fibrinogen and CNBr-digested fibrinogen, under assay conditions similar to those described by Hoylaerts et al. (J Biol Chem, 257, 2912, 1982).
A Electricwala, R J Ling, Atkinson T
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