Results 61 to 70 of about 69,236 (249)
Mediators of Inflammation, 2014 Chagas disease, caused by the protozoan parasite Trypanosoma cruzi (T. cruzi), is characterized by immunopathology driven by IFN-γ secreting Th1-like T cells. T.
Lúcia Cristina Jamli Abel +7 more
doaj +1 more source
International Journal for Parasitology: Parasites and Wildlife, 2022 Didelphis marsupialis has been reported as a competent reservoir for trypanosomatid parasites infections. The aim of this study was to measure Trypanosoma cruzi, T. rangeli, and Leishmania spp.
Vanessa J. Pineda +9 more
doaj +1 more source
British Journal of Pharmacology, EarlyView.Background and Purpose Whereas the effects of Trypanosoma cruzi (T. cruzi) infection are well‐characterised in the heart, its impact on the vasculature has received little attention. In this study, we investigated the effects of acute and chronic T. cruzi infection on vascular responsiveness and the underlying mechanisms.
Thales M. H. Dourado +6 more
wiley +1 more source
The return of metabolism: biochemistry and physiology of glycolysis
Biological Reviews, EarlyView.ABSTRACT Glycolysis is a fundamental metabolic pathway central to the bioenergetics and physiology of virtually all living organisms. In this comprehensive review, we explore the intricate biochemical principles and evolutionary origins of glycolytic pathways, from the classical Embden–Meyerhof–Parnas (EMP) pathway in humans to various prokaryotic and ...
Nana‐Maria Grüning +19 more
wiley +1 more source
Tropical Medicine and Infectious Disease, 2022 Chagas disease, caused by the protozoa Trypanosoma cruzi, is an important yet neglected disease that represents a severe public health problem in the Americas.
Constantino González-Salazar +8 more
doaj +1 more source
The FEBS Journal, EarlyView.Heteromeric cis‐prenyltransferases (CPT) are indispensable for dolichol synthesis and protein N‐glycosylation in most eukaryotes. The catalytic subunits are strongly conserved throughout evolution, in contrast to the evolutionarily variable accessory subunits. The POC1 protein from Paramecium tetraurelia is the smallest identified CPT‐accessory subunit
Agnieszka Onysk +8 more
wiley +1 more source
Analyses of 32 loci clarify phylogenetic relationships among Trypanosoma cruzi lineages and support a single hybridization prior to human contact. [PDF]
PLoS Neglected Tropical Diseases, 2011 The genetic diversity of Trypanosoma cruzi, the etiological agent of Chagas disease, has been traditionally divided in two major groups, T. cruzi I and II, corresponding to discrete typing units TcI and TcII-VI under a recently proposed nomenclature. The
Carlos A Flores-López, Carlos A Machado
doaj +1 more source
Mice with genetic deletion of group VIA phospholipase A2β exhibit impaired macrophage function and increased parasite load in Trypanosoma cruzi-induced myocarditis [PDF]
, 2016 Trypanosoma cruzi infection, which is the etiological agent of Chagas disease, is associated with intense inflammation during the acute and chronic phases.
Blase, Jennifer R +5 more
core +2 more sources
The structural, functional, and therapeutic potential of metacaspases in fungi and protozoa
The FEBS Journal, EarlyView.Metacaspases are Ca2+‐dependent cysteine proteases whose structural characteristics, particularly calcium binding and autocatalytic processing, govern their activation and biological functions. These enzymes differ among microorganisms and regulate their cell cycles, making them excellent targets for drug development.
Ane C. M. Duarte +9 more
wiley +1 more source
Memorias do Instituto Oswaldo Cruz, 2003 Morpho-biological diversity of Trypanosoma cruzi has been known since Chagas' first works in 1909. Several further studies confirmed the morphological differences among the parasite strains, which were isolated from different reservoirs and vectors, as ...
Devera Rodolfo +2 more
doaj +3 more sources