Results 121 to 130 of about 628 (165)
TAAR1 deficiency impairs mitochondrial dynamics and synaptic integrity in the medial prefrontal cortex and associated cognition in mice. [PDF]
Transl PsychiatryZhang XQ +7 more
europepmc +1 more source
Circulating thyroid hormones and metabolites in children with autism spectrum disorder. [PDF]
Front Endocrinol (Lausanne)Hancock M +9 more
europepmc +1 more source
Hormones and Behavior, 2017 We previously demonstrated that 3-iodothyronamine (T1AM), a by-product of thyroid hormone metabolism, pharmacologically administered to mice acutely stimulated learning and memory acquisition and provided hyperalgesia with a mechanism which remains to be defined.
Ersilia Lucenteforte +2 more
exaly +8 more sources
European Journal of Pharmacology, 2021 The 3-iodothyronamine (T1AM) and 3-iodothryoacetic acid (TA1), are endogenous occurring compounds structurally related with thyroid hormones (THs, the pro-hormone T4 and the active hormone T3) initially proposed as possible mediators of the rapid effects of T3.
Annunziatina Laurino +2 more
exaly +5 more sources
Uptake and metabolic effects of 3-iodothyronamine (T1AM) in hepatocytes
, 2014 3-Iodothyronamine (T1AM) is an endogenous relative of thyroid hormone with profound metabolic effects. In different experimental models, T1AM increased blood glucose, and it is not clear whether this effect is entirely accounted by changes in insulin and/or glucagone secretion.
GHELARDONI, SANDRA +4 more
openaire +3 more sources
, 2018 Thyroxine (T4) is the predominant form of thyroid hormone (TH). In target tissues, T4 is enzymatically deiodinated to 3,5,3′-triiodothyronine (T3), a high-affinity ligand for the nuclear TH receptors TRα and Trβ. T3 modulates genes transcription via activation of TRα and TRβ. Non-genomic effects have also been described.
Leonardo Lorenzini
core +3 more sources
Endocrine Abstracts, 2017 3-Iodothyronamine (T1AM) is a hormone like molecule structurally similar to TH, that has been reported to modulate energy metabolism by favoring lipid over glucose catabolism. To better understand the role played by T1AM on the regulation of lipid metabolism, in the present study we administered spontaneously obese mice with T1AM at two different ...
Martina Sabatini +5 more
openaire +2 more sources
Deciphering the potential of 3-iodothyronamine (T1AM) in regulating lipid metabolism
, 2015 3-iodothyronamine (T1AM) is a novel chemical messenger that has been reported to regulate energy metabolism and body weight. To better characterize its effects in a subacute model, we treated obese mice with two different dosages of T1AM for seven days, and analyzed plasma and tissue extracts using multidisciplinary approaches.
Assadi Porter F +11 more
openaire +3 more sources
3-iodothyronamine (T1AM) induces changes on glutamatergic postsynaptic signaling pathway
, 2019 Objective: Exogenous 3-iodothyronamine (T1AM), a derivative of thyroid hormone, produces antiamnestic and prolearning effects in mice. Glutamatergic neurotransmission, the major excitatory system in brain, plays a key role in regulating neuroplasticity, learning and memory, and it is often compromised in neurological disorders.
Bandini Lavinia +5 more
openaire +2 more sources