Results 11 to 20 of about 12,333 (188)
Unraveling and characterization of novel T3SS effectors in Edwardsiella piscicida
mSphere, 2023 ABSTRACT Type III secretion system (T3SS) facilitates survival and replication of Edwardsiella piscicida in vivo . Identifying novel T3SS effectors and elucidating their functions are critical in understanding the pathogenesis of E. piscicida. E.
Xiao Jian Liao +8 more
openaire +4 more sources
mBioABSTRACT Multilayered epithelia lining our tissue surfaces normally resist traversal by opportunistic bacteria. Previously, we developed a strategy to experimentally perturb this resistance in situ in the corneas of mouse eyes ...
Eric Jedel +6 more
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Unprecedented Protein Divergence Within a T3SS Family [PDF]
SSRN Electronic Journal, 2021 Selection pressure drives rapid emergence of antibiotic resistance mechanisms promoting searches for therapeutic targets in bacterial processes needed for virulence, not viability, which include the Type Three Secretion System (T3SS). Distinct T3SS families evolved from the flagellar export apparatus where remaining homology hinders development of anti-
Azzeldin Madkour +3 more
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Quorum sensing employs a dual regulatory mechanism to repress T3SS gene expression
mBioABSTRACT The type III secretion system (T3SS) is a needle-like complex used by numerous bacterial pathogens in host infection to inject exotoxins into the host cell cytoplasm.
Payel Paul +6 more
doaj +6 more sources
Characterization of Virulence Function of Avirulence Protein E1 (AvrE1) during Host Plant Infection [PDF]
The Plant Pathology Journal, 2021 Pseudomonas cichorii secretes effectors that suppress defense mechanisms in host plants. However, the function of these effectors, including avirulence protein E1 (AvrE1), in the pathogenicity of P. cichorii, remains unexplored.
Duyen Do Tran Huong +2 more
doaj +1 more source
An intra-bacterial activity for a T3SS effector [PDF]
Scientific Reports, 2020 Abstract Many Gram-negative bacterial pathogens interact with mammalian cells by using type III secretion systems (T3SS) to inject virulence proteins into host cells. A subset of these injected protein ‘effectors’ are enzymes that inhibit the function of host proteins by catalyzing the addition of unusual post ...
El Qaidi, S +5 more
openaire +3 more sources
Molecular Targets and Strategies for Inhibition of the Bacterial Type III Secretion System (T3SS); Inhibitors Directly Binding to T3SS Components [PDF]
Biomolecules, 2021 The type III secretion system (T3SS) is a virulence apparatus used by many Gram-negative pathogenic bacteria to cause infections. Pathogens utilizing a T3SS are responsible for millions of infections yearly. Since many T3SS knockout strains are incapable of causing systemic infection, the T3SS has emerged as an attractive anti-virulence target for ...
Julia A. Hotinger +2 more
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The T3SS Effector Protease NleC Is Active within Citrobacter rodentium [PDF]
Pathogens, 2021 Whether type III secretion system (T3SS) effector proteins encoded by Gram-negative bacterial pathogens have intra-bacterial activities is an important and emerging area of investigation. Gram-negative bacteria interact with their mammalian hosts by using secretion systems to inject virulence proteins directly into infected host cells.
Md Kamrul Hasan +2 more
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HrpS Is a Global Regulator on Type III Secretion System (T3SS) and Non-T3SS Genes in Pseudomonas savastanoi pv. phaseolicola [PDF]
Molecular Plant-Microbe Interactions®, 2018 The type III secretion system (T3SS) is the main machinery for Pseudomonas savastanoi and other gram-negative bacteria to invade plant cells. HrpR and HrpS form a hetero-hexamer, which activates the expression of HrpL, which induces all T3SS genes by binding to a ‘hrp box’ in promoters.
Jingru Wang +11 more
openalex +5 more sources
Autoinducer-2 and bile salts induce c-di-GMP synthesis to repress the T3SS via a T3SS chaperone
Nature Communications, 2022 Abstract Cyclic di-GMP (c-di-GMP) transduces extracellular stimuli into intracellular responses, coordinating a plethora of important biological processes. Low levels of c-di-GMP are often associated with highly virulent behavior that depends on the type III secretion system (T3SS) effectors encoded, whereas ...
Shuyu Li +13 more
openaire +3 more sources