Results 101 to 110 of about 8,006,579 (361)

TGF-β-responsive CAR-T cells promote anti-tumor immune function. [PDF]

open access: yes, 2018
A chimeric antigen receptor (CAR) that responds to transforming growth factor beta (TGF-β) enables the engineering of T cells that convert this immunosuppressive cytokine into a potent T-cell stimulant.
Chang, ZeNan L   +4 more
core   +1 more source

Characteristics of the Kelch domain containing (KLHDC) subfamily and relationships with diseases

open access: yesFEBS Letters, EarlyView.
The Kelch protein superfamily includes 63 members, with the KLHDC subfamily having 10 proteins. While their functions are not fully understood, recent advances in KLHDC2's structure and role in protein degradation have highlighted its potential for drug development, especially in PROTAC therapies.
Courtney Pilcher   +6 more
wiley   +1 more source

Cell-cell interactions in synovitis. Endothelial cells and immune cell migration.

open access: yesArthritis research, 2000
Leukocyte ingress into the synovium is a key process in the pathogenesis of rheumatoid arthritis and other inflammatory conditions. In this review, the role of endothelial cells in leukocyte extravasation will be discussed, including the role of the most relevant cellular adhesion molecules. These molecules play an important role in mediating leukocyte-
Zoltán Szekanecz   +2 more
openaire   +3 more sources

Regulatory Role of Mesenchymal Stem Cells on Secondary Inflammation in Spinal Cord Injury

open access: yesJournal of Inflammation Research, 2022
Qi-Ming Pang,1,2 Si-Yu Chen,1 Sheng-Ping Fu,1,2 Hui Zhou,3 Qian Zhang,4 Jun Ao,2 Xiao-Ping Luo,1 Tao Zhang1,2 1Key Laboratory of Cell Engineering of Guizhou Province and Regenerative Medicine Centre, Affiliated Hospital of Zunyi Medical University, Zunyi,
Pang QM   +7 more
doaj  

Insertion of the FeB cofactor in cNORs lacking metal inserting chaperones

open access: yesFEBS Letters, EarlyView.
Nitric oxide reductase is an enzyme found in the bacterial denitrification pathway. The NOR active site contains a non‐heme iron, often, but not always inserted with the assistance of chaperones. Here, we study the insertion of FeB in the subfamily of cNORs lacking chaperones and found a putative channel, conserved in the family, perhaps enabling the ...
Sofia Appelgren, Pia Ädelroth
wiley   +1 more source

Effects of Repeated Lipopolysaccharide Stimulation on the Development of Antigen-presenting Cells and T Cells Pool in Hen Vagina

open access: yesThe Journal of Poultry Science, 2013
The aim of this study was to determine how the mucosal immunity mediated by T cells is developed in the vagina. Antigen-presenting cells and T cells play important roles in the early process of host defense.
Takahiro Nii   +2 more
doaj   +1 more source

Structural and mechanistic basis for the regulation of the chloroplast signal recognition particle by (p)ppGpp

open access: yesFEBS Letters, EarlyView.
LHCPs are transported to the thylakoid membrane via the (cp)SRP pathway. This process involves a transit complex of (cp)SRP43, (cp)SRP54 and LHCP, which interacts with (cp)FtsY and Alb3 at the membrane. GTP hydrolysis by (cp)SRP54 and (cp)FtsY triggers complex dissociation.
Victor Zegarra   +7 more
wiley   +1 more source

Expression of MMP-14 and CD147 in Gingival Tissue of Patients With and Without Diabetes Mellitus Type II

open access: yesDiagnostics
Background: Diabetes mellitus (DM) is a major risk factor for the development of periodontal disease and aggravates the severity of periodontal conditions.
Ionut Catalin Botezatu   +11 more
doaj   +1 more source

Spiral Phyllotaxis Pattern in an Animal Cell: A Fluid- Driven Mechanism for Red Cell Echinocytosis and Programmed Cell Death [PDF]

open access: yesarXiv, 2004
This paper demonstrates that the pattern of lipid spiculesthat emerge on the surface of red blood cells in the classic 'Discocyte to Echinocyte' shape change is a generative spiral, and presents a qualitative, fluid- driven mechanism for their production, compatible with the work of Douady and Couder. Implications for the dynamics of cell growth, plant
arxiv  

Molecular Genetics of T Cell Development [PDF]

open access: yes, 2005
T cell development is guided by a complex set of transcription factors that act recursively, in different combinations, at each of the developmental choice points from T-lineage specification to peripheral T cell specialization. This review describes the
Aifantis I   +27 more
core   +1 more source

Home - About - Disclaimer - Privacy