Results 161 to 170 of about 8,198,133 (306)

Data‐driven discovery of gene expression markers distinguishing pediatric acute lymphoblastic leukemia subtypes

Molecular Oncology, EarlyView.
This study investigates gene expression differences between two major pediatric acute lymphoblastic leukemia (ALL) subtypes, B‐cell precursor ALL, and T‐cell ALL, using a data‐driven approach consisting of biostatistics and machine learning methods. Following analysis of a discovery dataset, we find a set of 14 expression markers differentiating the ...
Mona Nourbakhsh, Nikola Tom, Anna Schrøder Lassen, Helene Brasch Lind Petersen, Ulrik Kristoffer Stoltze, Karin Wadt, Kjeld Schmiegelow, Matteo Tiberti, Elena Papaleo   +8 more
wiley   +1 more source

Cell cycle, cell division, cell death

Molecular Biology of the Cell, 2019
Jan M. Skotheim, Amy Shaub Maddox
openaire   +2 more sources

Early methionine availability attenuates T cell exhaustion. [PDF]

Nat Immunol
Sharma P, Guo A, Poudel S, Boada-Romero E, Verbist KC, Palacios G, Immadisetty K, Chen MJ, Haydar D, Mishra A, Peng J, Babu MM, Krenciute G, Glazer ES, Green DR.   +14 more
europepmc   +1 more source

TRPM8 levels determine tumor vulnerability to channel agonists

Molecular Oncology, EarlyView.
TRPM8 is a Ca2+ permissive channel. Regardless of the amount of its transcript, high levels of TRPM8 protein mark different tumors, including prostate, breast, colorectal, and lung carcinomas. Targeting TRPM8 with channel agonists stimulates inward calcium currents followed by emptying of cytosolic Ca2+ stores in cancer cells.
Alessandro Alaimo, Francesco Giuseppe Carbone, Kristi Buzo, Nicole Annesi, Sacha Genovesi, Annalisa Lorenzato, Karen Widmann, Michela Libergoli, Elisa Marmocchi, Giovanni Bertalot, Alberto Brolese, Mauro Giulio Papotti, Luca Molinaro, Orazio Caffo, Mattia Barbareschi, Alberto Bardelli, Alessandro Romanel, Sabrina Arena, Andrea Lunardi   +18 more
wiley   +1 more source

In vitro HIV DNA integration in STAT3 drives T cell persistence-A model of HIV-associated T cell lymphoma. [PDF]

PLoS Pathog
Rist M, Kaku M, Coffin JM.
europepmc   +1 more source

Ly and Ia antigen phenotypes of T cells involved in delayed-type hypersensitivity and in suppression. [PDF]

, 1976
Mathew A. Vadas, J. F. A. P. Miller, Ian F. C. McKenzie, Stanley E. Chism, F W Shen, Edward A. Boyse, Jennifer R. Gamble, Alison Whitelaw   +7 more
openalex   +1 more source

The anticancer effect of the HDAC inhibitor belinostat is enhanced by inhibitors of Bcl‐xL or Mcl‐1 in ovarian cancer

Molecular Oncology, EarlyView.
The pan‐HDAC inhibitor belinostat increases the expression of the pro‐apoptotic proteins Bim, Puma, and Noxa and induces apoptosis in ovarian cancer cell lines and patient‐derived tumor organoids when used at high concentrations. Moreover, inhibiting the anti‐apoptotic proteins Bcl‐xL or Mcl‐1 sensitizes these preclinical models to the cytotoxic effect
Cécilia Thomine, Sterenn Guillemot, Louis‐Bastien Weiswald, Romane Florent, Edwige Abeilard, Florence Giffard, Emilie Brotin, Mélanie Briand, Enora Dolivet, Laurent Poulain, Marie Villedieu   +10 more
wiley   +1 more source

Targeted Therapy of CAR+ T-Cell Lymphoma after Anti-BCMA CAR T-Cell Therapy. [PDF]

N Engl J Med
Aleman A, Van Oekelen O, Melnekoff DT, Grossman L, Mouhieddine TH, Kurowski A, Odak I, Reci S, Desai S, Meledathu S, Naidu MP, Shukla RP, Dutta RP, Kappes K, Serebryakova K, Jackson H, Lu J, Chatikhine A, Kulkarni R, Moinfar Z, Croken MM, Mehrotra M, Baskovich B, Rayamajhi S, Richard S, Rossi AC, Salib C, Houldsworth J, Brown BD, Merad M, Laganà A, Brunner PM, Jagannath S, Brody JD, Parekh S.   +34 more
europepmc   +1 more source

T Cell Helper Defect in Patients with Chronic Lymphocytic Leukemia [PDF]

, 1979
Nicholas Chiorazzi, Shu Man Fu, Ghodrat Montazeri, Henry G. Kunkel, R. Kanti, Tracy A. Gee   +5 more
openalex   +1 more source

Systematic profiling of cancer‐fibroblast interactions reveals drug combinations in ovarian cancer

Molecular Oncology, EarlyView.
Fibroblasts, cells in the tumor environment, support ovarian cancer cell growth and alter morphology and drug response. We used fibroblast and cancer cell co‐culture models to test 528 drugs and discovered new drugs for combination treatment. We showed that adding Vorinostat or Birinapant to standard chemotherapy may improve drug response, suggesting ...
Greta Gudoityte, Osheen Sharma, Laura Leuenberger, Emelie Wallin, Josefin Fernebro, Päivi Östling, Rebecka Bergström, Johan Lindberg, Ulrika Joneborg, Olli Kallioniemi, Brinton Seashore‐Ludlow   +10 more
wiley   +1 more source