Results 161 to 170 of about 28,819,884 (406)

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Identification of a CD4+ T cell-stimulating antigen of pathogenic bacteria by expression cloning. [PDF]

, 1995
Identifying the immunogenic proteins that elicit pathogen-specific T cell responses is key to rational vaccine design. While several approaches have succeeded in identifying major histocompatibility complex (MHC) class I bound peptides that stimulate CD8+
Campbell, D, Sanderson, S, SHASTRI, Nilabh   +2 more
core   +1 more source

COVID-19 vaccine BNT162b1 elicits human antibody and TH1 T cell responses

Nature, 2020
U. Şahin, A. Muik, E. Derhovanessian, I. Vogler, L. Kranz, M. Vormehr, A. Baum, Kristen E. Pascal, Jasmin Quandt, D. Maurus, Sebastian Brachtendorf, Verena Lörks, Julian Sikorski, R. Hilker, D. Becker, Ann-Kathrin Eller, J. Grützner, Carsten Boesler, Corinna Rosenbaum, Marie-Cristine Kühnle, U. Luxemburger, Alexandra Kemmer-Brück, D. Langer, M. Bexon, S. Bolte, K. Karikó, T. Palanché, Boris Fischer, A. Schultz, P. Shi, Camila R. Fontes-Garfias, John L. Perez, K. Swanson, Jakob Loschko, Ingrid L Scully, Mark Cutler, W. Kalina, C. Kyratsous, David Cooper, P. Dormitzer, K. Jansen, Ö. Türeci   +41 more
semanticscholar   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Natural Killer T Cells in Cancer Immunotherapy [PDF]

, 2017
Shiny Nair, Madhav V. Dhodapkar
openalex   +1 more source

Axicabtagene Ciloleucel CAR T‐Cell Therapy in Refractory Large B‐Cell Lymphoma

New England Journal of Medicine, 2017
S. Neelapu, F. Locke, N. Bartlett, L. Lekakis, D. Miklos, C. Jacobson, I. Braunschweig, O. Oluwole, T. Siddiqi, Yi Lin, J. Timmerman, P. Stiff, J. Friedberg, I. Flinn, A. Goy, B. Hill, Mitchell R. Smith, A. Deol, U. Farooq, P. Mcsweeney, J. Muñoz, I. Avivi, J. Castro, J. Westin, J. Chavez, A. Ghobadi, K. Komanduri, R. Levy, E. Jacobsen, T. Witzig, P. Reagan, A. Bot, J. Rossi, L. Navale, Yi-zhou Jiang, J. Aycock, M. Elias, David D. Chang, J. Wiezorek, W. Go   +39 more
semanticscholar   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Mobilization of CD8+ T Cells via CXCR4 Blockade Facilitates PD-1 Checkpoint Therapy in Human Pancreatic Cancer [PDF]

, 2019
Yongwoo David Seo, Xiuyun Jiang, Kevin M. Sullivan, Florencia G. Jalikis, Kimberly S. Smythe, Arezou Abbasi, Marissa Vignali, James O. Park, Sara K. Daniel, Seth M. Pollack, Teresa S. Kim, Raymond S. Yeung, Ian Nicholas Crispe, Robert H. Pierce, Harlan Robins, Venu G. Pillarisetty   +15 more
openalex   +1 more source

Signatures of T cell dysfunction and exclusion predict cancer immunotherapy response

Nature Medicine, 2018
Peng Jiang, Shengqing Gu, D. Pan, Jingxin Fu, A. Sahu, Xihao Hu, Ziyi Li, Nicole Traugh, Xia Bu, Bo Li, Bo Li, Jun Liu, G. Freeman, Myles A. Brown, K. Wucherpfennig, X. Liu   +15 more
semanticscholar   +1 more source

CD8+ T cell differentiation and dysfunction in cancer

Nature reviews. Immunology, 2021
M. Philip, A. Schietinger
semanticscholar   +1 more source