Results 191 to 200 of about 8,676,743 (305)

Changes in the cellular microRNA profile by the intracellular expression of HIV-1 Tat regulator: A potential mechanism for resistance to apoptosis and impaired proliferation in HIV-1 infected CD4+ T cells

, 2017
María Sánchez-Del Cojo, María Rosa López‐Huertas, Francisco Díez‐Fuertes, Sara Rodríguez-Mora, Mercedes Bermejo, Guillermo López–Campos, Elena Mateos, Laura Jiménez-Tormo, Francisco Gómez‐Esquer, Gema Dı́az-Gil, José Alcamı́, Mayte Coiras   +11 more
openalex   +2 more sources

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Drug-loaded bispecific T cell nanoengager overcomes T cell exhaustion for potent cancer immunotherapy. [PDF]

Proc Natl Acad Sci U S A
Wang J, Huang X, Shi Q, Swingle KL, Hamilton AG, Gong N, Mitchell MJ.   +6 more
europepmc   +1 more source

PD-1-Dependent Mechanisms Maintain Peripheral Tolerance of Donor-Reactive CD8+ T Cells to Transplanted Tissue [PDF]

, 2008
Brent H. Koehn, Mandy L. Ford, Ivana R. Ferrer, Keshawna Borom, Shivaprakash Gangappa, Allan D. Kirk, Christian P. Larsen   +6 more
openalex   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Predictive markers for the efficacy of CAR T-cell therapy: the interplay between CAR T-cell fitness and systemic immunity. [PDF]

Blood Adv
Yoo KH, Szymura S, Dong Z, Kandel A, Cha SC, Kwak LW.   +5 more
europepmc   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Abnormal T-Cell activation and cytotoxic T-Cell frequency discriminate symptom severity in myalgic encephalomyelitis/chronic fatigue syndrome. [PDF]

J Transl Med
Lee JS, Lacerda E, Kingdon C, Abken E, Susannini G, Dockrell HM, Nacul L, Cliff JM.   +7 more
europepmc   +1 more source

Reducing and controlling metabolic active tumor volume prior to CAR T-cell infusion can improve survival outcomes in patients with large B-cell lymphoma [PDF]

Kylie Keijzer, Janneke de Boer, Jaap A. van Doesum, Walter Noordzij, Gerwin Huls, Lisanne V. van Dijk, Tom van Meerten, Anne G.H. Niezink   +7 more
openalex   +1 more source

PI3K Orchestrates T Follicular Helper Cell Differentiation in a Context Dependent Manner: Implications for Autoimmunity [PDF]

, 2019
Silvia Preite, Bonnie Huang, Jennifer L. Cannons, Dorian B. McGavern, Pamela L. Schwartzberg   +4 more
openalex   +1 more source