Results 191 to 200 of about 8,713,756 (356)

Spatial Proximity of LAG-3 and T Cell Receptor: A New Paradigm for T Cell Suppression. [PDF]

MedComm (2020)
Miao X, Feng X, Zhou F.
europepmc   +1 more source

The T cell repertoire in tumors overlaps with pulmonary inflammatory lesions in patients treated with checkpoint inhibitors [PDF]

, 2017
Heinz Läubli, Viktor H. Koelzer, Matthias S. Matter, Petra Herzig, Béatrice Dolder Schlienger, Mark Wiese, Didier Lardinois, Kirsten D. Mertz, Alfred Zippelius   +8 more
openalex   +1 more source

Cell density–dependent nuclear‐cytoplasmic shuttling of SETDB1 integrates with Hippo signaling to regulate YAP1‐mediated transcription

FEBS Letters, EarlyView.
At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom, Jaewoong Jang, Jung Sun Park, Yong‐Kook Kang   +3 more
wiley   +1 more source

Primary Cutaneous Peripheral T-Cell Lymphoma With Follicular Helper T-Cell Phenotype. [PDF]

J Cutan Pathol
Planella-Fontanillas N, Molina-Alvarez A, Colomo-Saperas L, Rovira R, Gonzàlez-Farré M, Barranco-Sanz C, Calvo X, Nadal-Pellisé C, Gallardo F, Pujol RM.   +9 more
europepmc   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

T cell-intrinsic PRR signaling in immunity and pathology. [PDF]

Acta Biochim Biophys Sin (Shanghai)
Shi Y, Wang M, Dai B, Lu X, Li S.
europepmc   +1 more source

Dysregulated MicroRNA Involvement in Multiple Sclerosis by Induction of T Helper 17 Cell Differentiation [PDF]

, 2018
Chen Chen, Yifan Zhou, Jingqi Wang, Yaping Yan, Lisheng Peng, Wei Qiu   +5 more
openalex   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Risk Factors Influencing Survival in T-Cell Lymphoblastic Lymphoma and T-Cell Acute Lymphoblastic Leukemia. [PDF]

Cancer Med
Kim TY, Min KI, Min GJ, Eom KS, Lee S, Cho SG, Kim S, Lee JH, Kim BS, Jeoung JW, Won HS, Yoon JH, Jeon Y.   +12 more
europepmc   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source