Results 211 to 220 of about 8,676,743 (305)

Distinct Localization, Transcriptional Profiles, and Functionality in Early Life Tonsil Regulatory T Cells [PDF]

S Verma, Marissa C. Bradley, Joshua I. Gray, Pranay Dogra, Daniel P. Caron, Sarah Maurrasse, Eli Grunstein, Erik H. Waldman, Minyoung Jang, Kalpana Pethe, Donna L. Färber, Thomas J. Connors   +11 more
openalex   +1 more source

Virtual memory CD8 T cells expanded by helminth infection confer broad protection against bacterial infection [PDF]

, 2018
Jr‐Shiuan Lin, Katja Mohrs, Frank M. Szaba, Lawrence W. Kummer, Elizabeth A. Leadbetter, Markus Mohrs   +5 more
openalex   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Unusual Presentation of Subcutaneous Panniculitis-Like T-Cell Lymphoma. [PDF]

Clin Case Rep
Alkallabi M, Alotaibi H, Nagshabandi KN, Bin Idris R, Abualola AH, Alshehri NA, Alhumidi A.   +6 more
europepmc   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Beyond FoxP3-Identification of a Chicken Regulatory T Cell Signature. [PDF]

Eur J Immunol
Naumann I, Ricemeyer ES, Elleder D, Plachy J, von La Roche D, Vučinić K, Göbel TW, Kaspers B, Früh SP, Härtle S.   +9 more
europepmc   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

HPV status shapes T-cell immunoprofiles in oesophageal adenocarcinoma: high regulatory T cell infiltration predicts poor prognosis. [PDF]

J Transl Med
Wui S, Hewavisenti RV, Rabiei M, Kelleher AD, Farzin M, Rajendra S, Sasson SC.   +6 more
europepmc   +1 more source

CD46-Induced Immunomodulatory CD4+ T Cells Express the Adhesion Molecule and Chemokine Receptor Pattern of Intestinal T Cells [PDF]

, 2008
Shannon K. Alford, Gregory D. Longmore, William F. Stenson, Claudia Kemper   +3 more
openalex   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source