Results 221 to 230 of about 28,819,884 (406)

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Single-Cell Transcriptome Reveals the Heterogeneity of T Cells in Mice with Systemic Lupus Erythematosus and Neuronal Inflammation

Journal of Inflammation Research
Zhijie Shi, Haihong Qin, Hao Wu Fudan University, Shanghai, People’s Republic of ChinaCorrespondence: Haihong Qin; Hao Wu, Email tjqhh1982@163.com; seaseewh@163.comIntroduction: Systemic lupus erythematosus is a heterogeneous autoimmune disease.
Shi Z, Qin H, Wu H
doaj  

Mitochondria Are Gate-keepers of T Cell Function by Producing the ATP That Drives Purinergic Signaling [PDF]

, 2014
Carola Ledderose, Yi Bao, Markus Lidicky, Johannes Zipperle, Lin Li, Katharina Strasser, Nathan I. Shapiro, Wolfgang G. Junger   +7 more
openalex   +1 more source

RORα is a critical checkpoint for T cell and ILC2 commitment in the embryonic thymus

, 2021
Ana C. F. Ferreira, Aydan C. H. Szeto, Morgan W. D. Heycock, Paula A. Clark, Jennifer A. Walker, Alastair Crisp, Jillian L. Barlow, Sophie Kitching, Alfred Lim, Mayuri Gogoi, Richard Berks, Maria Daly, Helen E. Jolin, Andrew N. J. McKenzie   +13 more
openalex   +2 more sources

Higher proportions of CD39+ tumor-resident cytotoxic T cells predict recurrence-free survival in patients with stage III melanoma treated with adjuvant immunotherapy [PDF]

, 2022
Grace H. Attrill, C. Owen, Tasnia Ahmed, Ismael A. Vergara, Andrew J. Colebatch, Jordan W. Conway, Kazi Nahar, John F. Thompson, Inês Pires da Silva, Matteo S. Carlino, Alexander M. Menzies, Serigne Lo, Umaimainthan Palendira, Richard A. Scolyer, Georgina V. Long, James S. Wilmott   +15 more
openalex   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Recognition of nectin-2 by the natural killer cell receptor T cell immunoglobulin and ITIM domain (TIGIT) [PDF]

, 2017
Felix A. Deuss, Benjamin S. Gully, Jamie Rossjohn, Richard Berry   +3 more
openalex   +1 more source

Differentiation of effector CD4 T cell populations (*).

Annual Review of Immunology, 2010
Jinfang Zhu, H. Yamane, W. Paul
semanticscholar   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Spatial Proximity of LAG-3 and T Cell Receptor: A New Paradigm for T Cell Suppression. [PDF]

MedComm (2020)
Miao X, Feng X, Zhou F.
europepmc   +1 more source