Results 41 to 50 of about 8,006,579 (361)

Cell–cell and cell–matrix interactions

open access: yesMolecular Biology of the Cell, 2012
Cell–cell and cell–extracellular matrix (ECM) interactions are fundamental to the complexity of multicellularity achieved in the metazoa. These interactions share many conceptual similarities, the most prominent being a dependence on transmembrane adhesion receptors, binding of adhesion receptors to specific extracellular ligand partners, and the ...
Josephine C. Adams, Kris A. DeMali
openaire   +2 more sources

Tethering of vesicles to the Golgi by GMAP210 controls LAT delivery to the immune synapse

open access: yesNature Communications, 2019
The immune synapse at the interface between T cells and antigen-presenting cells manifests intense vesicular trafficking, but how the vesicles are sorted is still unclear.
Andres Ernesto Zucchetti   +10 more
doaj   +1 more source

Challenging perspectives on the cellular origins of lymphoma [PDF]

open access: yesOpen Biology, 2016
Both B and T lymphocytes have signature traits that set them apart from other cell types. They actively and repeatedly rearrange their DNA in order to produce a unique and functional antigen receptor, they have potential for massive clonal expansion upon
Tim I. M. Malcolm   +3 more
doaj   +1 more source

MHCII restriction demonstrates B cells have very limited capacity to activate tumour-specific CD4+ T cells in vivo

open access: yesOncoImmunology
There has been growing interest in the role of B cells in antitumour immunity and potential use in adoptive cellular therapies. To date, the success of such therapies is limited.
Thomas V. Guy   +4 more
doaj   +1 more source

Downregulation of HMGB1 in thymoma cells affects T cell differentiation

open access: yesCentral European Journal of Immunology, 2023
Introduction: Thymoma is the most common anterior mediastinal tumor and is closely associated with myasthenia gravis (MG). Our previous study showed that the expression of Th17 cells increased and the expression of Treg decreased in MG-associated thymoma
Jian Li   +5 more
doaj   +1 more source

Cognate Interaction With CD4+ T Cells Instructs Tumor-Associated Macrophages to Acquire M1-Like Phenotype

open access: yesFrontiers in Immunology, 2019
The immunosuppressive tumor microenvironment (TME) established by tumor cells, stromal cells and inhibitory immune cells counteracts the function of tumor reactive T cells.
David Eisel   +9 more
doaj   +1 more source

Controversies concerning thymus-derived regulatory T cells: fundamental issues and a new perspective [PDF]

open access: yes, 2015
Thymus-derived regulatory T cells (Tregs) are considered to be a distinct T-cell lineage that is genetically programmed and specialised for immunosuppression.
Ono, M, Tanaka, RJ
core   +1 more source

Cell calcium, cell injury and cell death. [PDF]

open access: yesEnvironmental Health Perspectives, 1984
The role of calcium in cell injury has been the subject of much recent investigation. The movement and redistribution of this cation from extra to intracellular compartments and the calcium shifts between intracellular compartments may well play a determinate role in the cell's reaction to injury.
Kauno U. Laiho   +5 more
openaire   +3 more sources

Phylogenetic analysis of the SINA/SIAH ubiquitin E3 ligase family in Metazoa

open access: yesBMC Evolutionary Biology, 2017
Background The RAS signaling pathway is a pivotal developmental pathway that controls many fundamental biological processes including cell proliferation, differentiation, movement and apoptosis.
Ian J. Pepper   +2 more
doaj   +1 more source

Theories and quantification of thymic selection [PDF]

open access: yes, 2014
The peripheral T cell repertoire is sculpted from prototypic T cells in the thymus bearing randomly generated T cell receptors (TCR) and by a series of developmental and selection steps that remove cells that are unresponsive or overly reactive to self ...
Yates, Andrew J.
core   +2 more sources

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