Results 61 to 70 of about 25,344,545 (360)

IL-4 drives exhaustion of CD8+ CART cells

Nature Communications
Durable response to chimeric antigen receptor T (CART) cell therapy remains limited in part due to CART cell exhaustion. Here, we investigate the regulation of CART cell exhaustion with three independent approaches including: a genome-wide CRISPR ...
Carli M. Stewart, Elizabeth L. Siegler, R. Leo Sakemura, Michelle J. Cox, Truc Huynh, Brooke Kimball, Long Mai, Ismail Can, Claudia Manriquez Roman, Kun Yun, Olivia Sirpilla, James H. Girsch, Ekene Ogbodo, Wazim Mohammed Ismail, Alexandre Gaspar-Maia, Justin Budka, Jenny Kim, Nathalie Scholler, Mike Mattie, Simone Filosto, Saad S. Kenderian   +20 more
doaj   +1 more source

Downregulation of HMGB1 in thymoma cells affects T cell differentiation

Central European Journal of Immunology, 2023
Introduction: Thymoma is the most common anterior mediastinal tumor and is closely associated with myasthenia gravis (MG). Our previous study showed that the expression of Th17 cells increased and the expression of Treg decreased in MG-associated thymoma
Jian Li, Zeyang Zhang, Yuan Chen, Yuanguo Wang, Yuxin Liu, Peng Zhang   +5 more
doaj   +1 more source

The dual nature of TDC – bridging dendritic and T cells in immunity

FEBS Letters, EarlyView.
TDC are hematopoietic cells combining dendritic and T cell features. They reach secondary lymphoid organs (SLOs) and peripheral organs (liver and lungs) after FLT3‐dependent development in the bone marrow and maturation in the thymus. TDC are activated and enriched in SLOs upon viral infection, suggesting that they might play unique immune roles, since
Maria Nelli, Mirela Kuka
wiley   +1 more source

An injectable bone marrow-like scaffold enhances T cell immunity after hematopoietic stem cell transplantation. [PDF]

, 2019
Allogeneic hematopoietic stem cell transplantation (HSCT) is a curative treatment for multiple disorders, but deficiency and dysregulation of T cells limit its utility.
Deruaz, Maud, Kerr, Matthew D, Mao, Angelo S, Mooney, David J, Raimondo, Theresa M, Scadden, David T, Shah, Nisarg J, Sharda, Azeem, Shih, Ting-Yu, Tager, Andrew M, Vrbanac, Vladimir D, Weaver, James C   +11 more
core   +1 more source

Pre-existing virus-specific CD8+ T-cells provide protection against pneumovirus-induced disease in mice [PDF]

, 2012
Pneumoviruses such as pneumonia virus of mice (PVM), bovine respiratory syncytial virus (bRSV) or human (h)RSV are closely related pneumoviruses that cause severe respiratory disease in their respective hosts.
Alice J.A.M. Sijts, Alwan, Andrea Gröne, Andrew J. Easton, Bossert, Braciale, Buchholz, Cannon, Castilow, Chang, Chen, Chin, Claassen, Claassen, Claire J.P. Boog, Cornelis P.J. Bekker, David J. Topham, Dietmar M.W. Zaiss, Dirk H. Busch, Easton, Falsey, Fenton, Frey, Fulginiti, Garvey, Graham, Hall, Heinze, Henderson, Hussell, Kapikian, Kim, Kruijsen, Kulkarni, Lo, Mary J.G. van Helden, Ostler, Ostler, Percopo, Peter J.S. van Kooten, Piedra, Polakos, Rosenberg, Rosenberg, Sherman, Srikiatkhachorn, Stevens, Stevens, Thompson, Tregoning, Varga, Zaiss   +51 more
core   +1 more source

Recent advances in edible coating of food products and its legislations: A review

Journal of Agriculture and Food Research, 2023
Food products are highly perishable in nature which undergoes quick quality deterioration. In this note, the kind of packaging decides the active preservation of food qualities.
Krishna Priya, Nirmal Thirunavookarasu, D.V. Chidanand   +2 more
doaj  

CD8 T Cell Exhaustion During Chronic Viral Infection and Cancer.

Annual Review of Immunology, 2019
Exhausted CD8 T (Tex) cells are a distinct cell lineage that arise during chronic infections and cancers in animal models and humans. Tex cells are characterized by progressive loss of effector functions, high and sustained inhibitory receptor expression,
Laura M. McLane, Mohamed S. Abdel-Hakeem, E. Wherry   +2 more
semanticscholar   +1 more source

Leveraging current insights on IL‐10‐producing dendritic cells for developing effective immunotherapeutic approaches

FEBS Letters, EarlyView.
In vivo IL‐10 produced by tissue‐resident tolDC is involved in maintaining/inducing tolerance. Depending on the agent used for ex vivo tolDC generation, cells acquire common features but prime T cells towards anergy, FOXP3+ Tregs, or Tr1 cells according to the levels of IL‐10 produced. Ex vivo‐induced tolDC were administered to patients to re‐establish/
Konstantina Morali, Gloria Giacomello, Michela Vuono, Silvia Gregori   +3 more
wiley   +1 more source

Antigen-driven T-cell turnover.

, 2002
A mathematical model is developed to characterize the distribution of cell turnover rates within a population of T lymphocytes. Previous models of T-cell dynamics have assumed a constant uniform turnover rate; here we consider turnover in a cell pool ...
Anderson, Roy M, De Wolf, Frank, Ferguson, Neil M, Fraser, Christophe, Garnett, Geoff P, Ghani, Azra C   +5 more
core   +2 more sources

New directions in cellular therapy of cancer: a summary of the summit on cellular therapy for cancer [PDF]

, 2012
A summit on cellular therapy for cancer discussed and presented advances related to the use of adoptive cellular therapy for melanoma and other cancers. The summit revealed that this field is advancing rapidly.
A Lundqvist, A Somers, C Berger, CA Tran, Carolina Berger, Cornelis JM Melief, Daniel J Powell, David F Stroncek, DG Song, DJ Powell Jr, DL Porter, Francesco M Marincola, G Mostoslavsky, GG Kenter, Gustavo Mostoslavsky, J Jin, J Staerk, James R Heath, Jeffrey S Miller, JN Kochenderfer, JN Kochenderfer, John O'Shea, JS Miller, K Takahashi, L Gattinoni, L Gattinoni, L Gattinoni, L Gattinoni, LA Johnson, Luca Gattinoni, M Kalos, M Kalos, M Kalos, Mahendra Rao, Mark E Dudley, Martin A Cheever, ME Dudley, ME Dudley, Michael Kalos, Nicholas P Restifo, P Muranski, Peter Flynn, PF Robbins, RA Morgan, Richard W Childs, SA Rosenberg, Steven A Rosenberg, TS Park, X Wang   +48 more
core   +4 more sources