Results 71 to 80 of about 8,261,953 (362)

A Dynamical Systems Perspective on Chimeric Antigen Receptor T-Cell Dosing [PDF]

, 2018
Chimeric antigen receptor T cells (CAR T cells) are dosed similarly to donor lymphocyte infusions following hematopoietic cell transplantation. In this perspective paper a mathematical basis for personalized dosing of CAR T cells is introduced.
arxiv   +1 more source

Pre-existing virus-specific CD8+ T-cells provide protection against pneumovirus-induced disease in mice [PDF]

, 2012
Pneumoviruses such as pneumonia virus of mice (PVM), bovine respiratory syncytial virus (bRSV) or human (h)RSV are closely related pneumoviruses that cause severe respiratory disease in their respective hosts.
Alice J.A.M. Sijts, Alwan, Andrea Gröne, Andrew J. Easton, Bossert, Braciale, Buchholz, Cannon, Castilow, Chang, Chen, Chin, Claassen, Claassen, Claire J.P. Boog, Cornelis P.J. Bekker, David J. Topham, Dietmar M.W. Zaiss, Dirk H. Busch, Easton, Falsey, Fenton, Frey, Fulginiti, Garvey, Graham, Hall, Heinze, Henderson, Hussell, Kapikian, Kim, Kruijsen, Kulkarni, Lo, Mary J.G. van Helden, Ostler, Ostler, Percopo, Peter J.S. van Kooten, Piedra, Polakos, Rosenberg, Rosenberg, Sherman, Srikiatkhachorn, Stevens, Stevens, Thompson, Tregoning, Varga, Zaiss   +51 more
core   +1 more source

Cell-to-Cell Spread of Retroviruses [PDF]

Viruses, 2010
Viruses from several families use direct cell-to-cell infection to disseminate between cells. Retroviruses are a relatively recent addition to this list, and appear to spread cell-to-cell by induction of multimolecular complexes termed virological synapses that assemble at the interface between infected and receptor-expressing target cells.
openaire   +6 more sources

Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley   +1 more source

Hybrid spreading mechanisms and T cell activation shape the dynamics of HIV-1 infection [PDF]

PLOS Computational Biology. 2015 Apr 2;11(4):e1004179, 2015
HIV-1 can disseminate between susceptible cells by two mechanisms: cell-free infection following fluid-phase diffusion of virions and by highly-efficient direct cell-to-cell transmission at immune cell contacts. The contribution of this hybrid spreading mechanism, which is also a characteristic of some important computer worm outbreaks, to HIV-1 ...
arxiv   +1 more source

Antigen-driven T-cell turnover.

, 2002
A mathematical model is developed to characterize the distribution of cell turnover rates within a population of T lymphocytes. Previous models of T-cell dynamics have assumed a constant uniform turnover rate; here we consider turnover in a cell pool ...
Anderson, Roy M, De Wolf, Frank, Ferguson, Neil M, Fraser, Christophe, Garnett, Geoff P, Ghani, Azra C   +5 more
core   +2 more sources

Taurine promotes glucagon‐like peptide‐1 secretion in enteroendocrine L cells

FEBS Letters, EarlyView.
Taurine, a sulfur‐containing amino acid, is likely taken up by enteroendocrine L cells via the taurine transporter. This process increases the levels of cytosolic ATP. The increase in intracellular Ca2+ concentrations and glucagon‐like peptide‐1 secretion through membrane depolarization is caused by the closure of ATP‐sensitive potassium channels ...
Yuri Osuga, Kazuki Harada, Takuya Yamauchi, Tetsuya Kitaguchi, Masami Yokota Hirai, Mitsuharu Matsumoto, Takashi Tsuboi   +6 more
wiley   +1 more source

Extracellular matrix cues regulate the differentiation of pluripotent stem cell-derived endothelial cells

Frontiers in Cardiovascular Medicine, 2023
The generation of endothelial cells (ECs) from human pluripotent stem cells (PSCs) has been a promising approach for treating cardiovascular diseases for several years.
Kyung Mu Noh, Soon-Jung Park, Sung-Hwan Moon, Seok Yun Jung   +3 more
doaj   +1 more source

TGF-β-responsive CAR-T cells promote anti-tumor immune function. [PDF]

, 2018
A chimeric antigen receptor (CAR) that responds to transforming growth factor beta (TGF-β) enables the engineering of T cells that convert this immunosuppressive cytokine into a potent T-cell stimulant.
Chang, ZeNan L, Chen, Yvonne Y, Hou, Andrew J, Lorenzini, Michael H, Zah, Eugenia   +4 more
core   +1 more source

Making tau amyloid models in vitro: a crucial and underestimated challenge

FEBS Letters, EarlyView.
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley   +1 more source