Results 71 to 80 of about 28,819,735 (257)

TOX transcriptionally and epigenetically programs CD8+ T cell exhaustion

Nature, 2019
Exhausted CD8+ T (Tex) cells in chronic infections and cancer have limited effector function, high co-expression of inhibitory receptors and extensive transcriptional changes compared with effector (Teff) or memory (Tmem) CD8+ T cells.
O. Khan, Josephine R. Giles, Sierra J. McDonald, Sasikanth Manne, S. Ngiow, K. P. Patel, Michael T. Werner, Alexander C. Huang, Katherine A Alexander, Jennifer E. Wu, John Attanasio, P. Yan, Sangeeth M. George, Bertram Bengsch, Ryan P. Staupe, G. Donahue, W. Xu, R. Amaravadi, Xiaowei Xu, G. Karakousis, T. Mitchell, L. Schuchter, J. Kaye, S. Berger, E. Wherry   +24 more
semanticscholar   +1 more source

Expression of MMP-14 and CD147 in Gingival Tissue of Patients With and Without Diabetes Mellitus Type II

Diagnostics
Background: Diabetes mellitus (DM) is a major risk factor for the development of periodontal disease and aggravates the severity of periodontal conditions.
Ionut Catalin Botezatu, Maria-Alexandra Martu, Laura Stoica, Ana Emanuela Botez, Pavel Onofrei, Cristina Daniela Dimitriu, Bogdan Vasile Grecu, Ionut Daniel Gafincu Grigoriu, Oana Ciurcanu, Carmen Solcan, Anca Ileana Sin, Elena-Carmen Cotrutz   +11 more
doaj   +1 more source

Research Progress on the Mechanism and Clinical Data of Cereblon 
in Reversing the Resistance of Lung Cancer to PD-1 Antibody by T cells

Chinese Journal of Lung Cancer, 2021
Programmed cell death receptor 1 (PD-1) is a membrance-spanning protein mostly expressed in the T cell, and combines with programmed cell death ligand 1 (PD-L1) in the targeting cell.
Jingjing GUO, Di MU, Ying HAN
doaj   +1 more source

Engineering strategies to overcome the current roadblocks in CAR T cell therapy

Nature Reviews Clinical Oncology, 2019
T cells genetically engineered to express chimeric antigen receptors (CARs) have proven — and impressive — therapeutic activity in patients with certain subtypes of B cell leukaemia or lymphoma, with promising efficacy also demonstrated in patients with ...
S. Rafiq, Christopher S. Hackett, R. Brentjens   +2 more
semanticscholar   +1 more source

Regulation of T cell lymphokine production by killer cell inhibitory receptor recognition of self HLA class I alleles. [PDF]

, 1996
The killer cell inhibitory receptors (KIRs) are surface glycoproteins expressed by natural killer (NK) and T cells that specifically recognize defined groups of polymorphic human histocompatibility leukocyte antigen (HLA) class I molecules.
Chang, C, D'Andrea, A, Lanier, LL, Phillips, JH   +3 more
core  

Early Investigations and Recent Advances in Intraperitoneal Immunotherapy for Peritoneal Metastasis. [PDF]

, 2018
Peritoneal metastasis (PM) is an advanced stage malignancy largely refractory to modern therapy. Intraperitoneal (IP) immunotherapy offers a novel approach for the control of regional disease of the peritoneal cavity by breaking immune tolerance.
Bowne, Wilbur B., Katz, Steven C., Khalili, Marian, Morano, William F., Richard, Scott D., Thadi, Anusha   +5 more
core   +2 more sources

Astrocyte-targeted gene delivery of interleukin 2 specifically increases brain-resident regulatory T cell numbers and protects against pathological neuroinflammation [PDF]

, 2022
Lidia Yshii, Emanuela Pasciuto, Pascal Bielefeld, Loriana Mascali, Pierre Lemaître, Marika Marino, James Dooley, Lubna Kouser, Stijn Verschoren, Vasiliki Lagou, Hannelore Kemps, Pascal Gervois, Antina de Boer, Oliver T. Burton, Jérôme Wahis, Jens Verhaert, Samar Tareen, Carlos P. Roca, K. N. Singh, Carly E. Whyte, Axelle Kerstens, Zsuzsanna Callaerts‐Vegh, Suresh Poovathingal, Teresa Prezzemolo, Keimpe Wierda, Amy Dashwood, Junhua Xie, Elien Van Wonterghem, Eline Creemers, Meryem Aloulou, Willy Gsell, Oihane Abiega, Sebastian Munck, Roosmarijn E. Vandenbroucke, Annelies Bronckaers, Robin Lemmens, Bart De Strooper, Ludo Van Den Bosch, Uwe Himmelreich, Carlos P. Fitzsimons, Matthew G. Holt, Adrian Liston   +41 more
openalex   +1 more source

Effects of Repeated Lipopolysaccharide Stimulation on the Development of Antigen-presenting Cells and T Cells Pool in Hen Vagina

The Journal of Poultry Science, 2013
The aim of this study was to determine how the mucosal immunity mediated by T cells is developed in the vagina. Antigen-presenting cells and T cells play important roles in the early process of host defense.
Takahiro Nii, Naoki Isobe, Yukinori Yoshimura   +2 more
doaj   +1 more source

Editorial: Membrane lipids in T cell functions [PDF]

, 2018
Plasma membrane lipids play essential roles in regulating T cell signaling, differentiation, and effector functions. The major lipid species in the plasma membrane are glycerophospholipids, sphingolipids, and sterol lipids.
Tuosto, Loretta, Xu, Chenqi
core   +1 more source

Generalized Lévy walks and the role of chemokines in migration of effector CD8+ T cells. [PDF]

, 2012
Chemokines have a central role in regulating processes essential to the immune function of T cells, such as their migration within lymphoid tissues and targeting of pathogens in sites of inflammation.
Banigan, Edward J, Christian, David A, Harris, Tajie H, Hunter, Christopher A, John, Beena, Konradt, Christoph, Liu, Andrea J, Luster, Andrew D, Norose, Kazumi, Tait Wojno, Elia D, Weninger, Wolfgang, Wilson, Emma H   +11 more
core   +2 more sources