Results 131 to 140 of about 1,940,376 (313)

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

Human neutrophil clearance of bacterial pathogens triggers anti-microbial gamma delta T cell responses in early infection

, 2011
Human blood Vc9/Vd2 T cells, monocytes and neutrophils share a responsiveness toward inflammatory chemokines and are rapidly recruited to sites of infection.
Davey Martin S., Toleman Mark A., Davey, Martin S, Parish, T., Simon J. Davies, Gareth W Roberts, Williams, John David, Parish, T, Johnson, David W, John D Williams, David W Johnson, Davies, S. J., Tanya Parish, Brown, A. C., James A Chess, Chess, James Anthony, Johnson, D. W., Gareth W. Roberts, Lin Chan-Yu, Martin S. Davey, Heuston, Sinead, Toleman, Mark A., Heuston Sinéad, Cormac G. M. Gahan, Amanda C Brown, Martin S Davey, Johnson, David Westley, Roberts Gareth W., Gahan Cormac G. M., Davey, MS, Eberl, M, Gahan, C. G. M., Parish, Tanya, Chess, James A, Davies, Simon J, Hill, C., Moser Bernhard, Gahan, Cormac G M, James A. Chess, Williams, John D., Amanda C. Brown, Heuston, S., Brown, Amanda C., Moser, B, Brown, Amanda C, Davey, Martin S., Roberts, Gareth W., Johnson, David W., Toleman, MA, Toleman, Mark A, Davies Simon J., Gahan, CGM, David W. Johnson, Topley, N, Williams, John D, Bernhard Moser, Parish Tanya, Gahan, Cormac G., Topley Nicholas, Chess, JA, Moser, Bernhard, Williams, JD, Heuston, S, Johnson David W., Chess, James A., Gahan, Cormac G. M., Simon J Davies, Topley, Nicholas, Brown, AC, Hill Colin, Hill, C, Eberl, Matthias, Brown Amanda C., Davies, SJ, Mark A. Toleman, Cormac G M Gahan, Eberl Matthias, Mark A Toleman, Nicholas Topley, Hill, Colin, Chan-Yu Lin, Colin Hill, Toleman, Mark Alexander Howard, Roberts, GW, Lin, CY, Johnson, DW, Chess James A., Lin, Chan-Yu, Williams John D., Davies, Simon J., John D. Williams, Sinéad Heuston, Roberts, Gareth W, Matthias Eberl   +93 more
core   +1 more source

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

FEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source

Viral antigen mediated NKp46 activation of NK cells results in tumor rejection via NK-DC crosstalk

, 2012
Natural killer (NK) cells play a critical role in antitumor immunity, their activation being regulated through NK cell receptors. Although the endogenous ligands for these receptors are largely unknown, viral ligands have been identified. We investigated
Bateman, Andrew R, Elliott, Tim, James, Edward, Chinnery, Fay, King, Catherine A   +4 more
core   +1 more source

Electron transfer between complexes III and IV in S. cerevisiae mitochondrial membranes

FEBS Letters, EarlyView.
Mitochondrial oxidative phosphorylation in S. cerevisiae mitoplasts is limited by complex IV catalytic capacity, rather than two‐dimensional cytochrome c diffusion. At physiological cytochrome c : supercomplex ratios at salinity equivalent to that of 20 mm monovalent salt, activity is maximized, indicating that this low ionic strength accurately mimics
Ana Paula Lobez, Mikael Oliveberg, Peter Brzezinski   +2 more
wiley   +1 more source

Integrin linked kinase and threonine tyrosine kinase modulate TCR signaling

Scientific Reports
T cell activation is critical for adaptive immunity, helping to protect the body from infection and tumors. A key step in this activation is signal transduction downstream of the T cell antigen receptor.
Vivien Caillens, Eva Boisel, Alycia Ouksel, Mathilde Nugue, Irini Evnouchidou, Loredana Saveanu   +5 more
doaj   +1 more source