Results 1 to 10 of about 2,637,595 (353)
Protocol for assessing T cell receptor-mediated human T cell cytotoxicity [PDF]
STAR ProtocolsSummary: Measuring the cytotoxicity of human T cells is a valuable but challenging task. We present a protocol for assessing the ability of polyclonal human T cells to kill target cells upon T cell receptor (TCR) triggering.
Kathryne E. Marks +3 more
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TRain: T-cell receptor automated immunoinformatics [PDF]
BMC BioinformaticsBackground The scarcity of available structural data makes characterizing the binding of T-cell receptors (TCRs) to peptide-Major Histocompatibility Complexes (pMHCs) very challenging.
Austin Seamann +5 more
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Glutamate receptor–T cell receptor signaling potentiates full CD8+ T cell activation and effector function in tumor immunity [PDF]
iScienceSummary: Glutamate is best known as an excitatory neurotransmitter. However, its roles in T cell immunity remain underrecognized. We investigated the interplay between glutamate receptors (GluRs) and T cell receptors (TCRs) during CD8+ T cell activation.
Maria Teresa P. de Aquino +8 more
doaj +2 more sources
The T cell receptor sequence influences the likelihood of T cell memory formation [PDF]
Cell ReportsSummary: The amino acid sequence of the T cell receptor (TCR) varies between T cells of an individual’s immune system. Particular TCR residues nearly guarantee mucosal-associated invariant T (MAIT) and natural killer T (NKT) cell transcriptional fates ...
Kaitlyn A. Lagattuta +7 more
doaj +2 more sources
T cell receptor β-chain-targeting chimeric antigen receptor T cells against T cell malignancies
Nature Communications, 2022 Healthy T cells are polyclonal, while malignant T cells are developing via clonal expansion. Here authors show that T cell tumours could be eradicated by chimeric antigen receptor T cells targeting the T cell receptor (TCR) β-chain that is specific to ...
Fanlin Li +17 more
doaj +1 more source
Frontiers in Immunology, 2021 The inhibition of anabolic pathways, such as aerobic glycolysis, is a metabolic cornerstone of memory T cell differentiation and function. However, the signals that hamper these anabolic pathways are not completely known.
Raquel Blanco +8 more
doaj +1 more source
Journal of Veterinary Internal Medicine, 2021 Background T cell clonality assays in veterinary medicine currently target only the T cell receptor gamma (TRG) locus. Existing assays have suboptimal sensitivity because of insufficient primer coverage of all possible rearrangements.
Araya Radtanakatikanon +3 more
doaj +1 more source
Promising New Tools for Targeting p53 Mutant Cancers: Humoral and Cell-Based Immunotherapies
Frontiers in Immunology, 2021 Transcription factor and oncosuppressor protein p53 is considered as one of the most promising molecular targets that remains a high-hanging fruit in cancer therapy.
Vitaly Chasov +9 more
doaj +1 more source
Cell receptors and cell signalling [PDF]
Molecular Pathology, 2000 All cells in a multicellular organism are constantly exposed to a variety of extracellular signals that they need to interpret and translate into an appropriate response to their environment. These signals can be soluble factors generated locally (for example, synaptic transmission) or distantly (for example, hormones and growth factors), ligands on ...
S N Farrow, I J Uings
openaire +3 more sources
T cell receptor sequence clustering and antigen specificity
Computational and Structural Biotechnology Journal, 2020 There has been increasing interest in the role of T cells and their involvement in cancer, autoimmune and infectious diseases. However, the nature of T cell receptor (TCR) epitope recognition at a repertoire level is not yet fully understood.
Milena Vujovic +7 more
doaj +1 more source