Results 11 to 20 of about 1,632,256 (263)

T cell receptor signaling for γδT cell development

Inflammation and Regeneration, 2019
T cells are central to the vertebrate immune system. Two distinct types of T cells, αβT and γδT cells, express different types of T cell antigen receptors (TCRs), αβTCR and γδTCR, respectively, that are composed of different sets of somatically ...
Ryunosuke Muro, Hiroshi Takayanagi, Takeshi Nitta   +2 more
doaj   +1 more source

Germline T cell receptor exchange results in physiological T cell development and function

Nature Communications, 2023
The currently available transgenic T cell receptor (TCR) models represent high affinity antigen-TCR interactions. Authors here present an alternative approach to target an exogenous TCR into the physiological Trac locus in the germline of mice, which ...
Meagan R. Rollins, Jackson F. Raynor, Ebony A. Miller, Jonah Z. Butler, Ellen J. Spartz, Walker S. Lahr, Yun You, Adam L. Burrack, Branden S. Moriarity, Beau R. Webber, Ingunn M. Stromnes   +10 more
doaj   +1 more source

The LCMV gp33-specific memory T cell repertoire narrows with age

Immunity & Ageing, 2012
Background The memory response to LCMV in mice persists for months to years with only a small decrease in the number of epitope specific CD8 T cells. This long persistence is associated with resistance to lethal LCMV disease.
Bunztman Adam, Vincent Benjamin G, Krovi Harsha, Steele Shaun, Frelinger Jeffrey A   +4 more
doaj   +1 more source

Force generation upon T cell receptor engagement. [PDF]

PLoS ONE, 2011
T cells are major players of adaptive immune response in mammals. Recognition of an antigenic peptide in association with the major histocompatibility complex at the surface of an antigen presenting cell (APC) is a specific and sensitive process whose ...
Julien Husson, Karine Chemin, Armelle Bohineust, Claire Hivroz, Nelly Henry   +4 more
doaj   +1 more source

Discovery of the first PD-1 ligand encoded by a pathogen

Frontiers in Immunology, 2022
Large double-stranded DNA viruses deploy multiple strategies to subvert host immune defenses. Some of these tactics are mediated by viral gene products acquired by horizontal gene transfer from the corresponding hosts and shaped throughout evolution. The
Pablo Martínez-Vicente, Francesc Poblador, Judith Leitner, Domènec Farré, Peter Steinberger, Pablo Engel, Pablo Engel, Ana Angulo, Ana Angulo   +8 more
doaj   +1 more source

Drug functional remapping: a new promise for tumor immunotherapy

Frontiers in Oncology
The research and development of new anti-cancer drugs face challenges such as high costs, lengthy development cycles, and limited data on side effects.
Jiayi Dong, Jiayi Dong, Jiayi Dong, Ting Su, Ting Su, Ting Su, Ting Su, Jiexiong Wu, Yu Xiang, Yu Xiang, Yu Xiang, Yu Xiang, Minghan Song, Minghan Song, Minghan Song, Canfeng He, Canfeng He, Canfeng He, Lijuan Shao, Lijuan Shao, Lijuan Shao, Lijuan Shao, Yubin Yang, Yubin Yang, Size Chen, Size Chen, Size Chen, Size Chen   +27 more
doaj   +1 more source

Fit αβ T-cell receptor suppresses leukemogenesis of Pten-deficient thymocytes

Haematologica, 2018
Signaling through the αβT cell receptor (TCR) is a crucial determinant of T-cell fate and can induce two opposite outcomes during thymocyte development: cell death or survival and differentiation.
Stéphanie Gon, Marie Loosveld, Thomas Crouzet, Delphine Potier, Mélanie Bonnet, Stéphanie O. Morin, Gérard Michel, Norbert Vey, Jacques A. Nunès, Bernard Malissen, Romain Roncagalli, Bertrand Nadel, Dominique Payet-Bornet   +12 more
doaj   +1 more source

A Novel Approach for the Treatment of T Cell Malignancies: Targeting T Cell Receptor Vβ Families

Vaccines, 2020
Peripheral T cell lymphomas (PTCLs) are generally chemotherapy resistant and have a poor prognosis. The lack of targeted immunotherapeutic approaches for T cell malignancies results in part from potential risks associated with targeting broadly expressed
Jie Wang, Katarzyna Urbanska, Prannda Sharma, Reza Nejati, Lauren Shaw, Megan S. Lim, Stephen J. Schuster, Daniel J. Powell Jr.   +7 more
doaj   +1 more source

T cell receptor signaling and cell immunotherapy

National Science Open
As the major sensor of adaptive immune system, T cell receptor (TCR) can recognize diverse antigens and initiate specific immune responses against invading pathogens and cancer cells.
Zhang Linsong, Xu Xinyi, Shi Xiaoshan, Xu Chenqi   +3 more
doaj   +1 more source

Crystalline silica activates the T-cell and the B-cell antigen receptor complexes and induces T-cell and B-cell proliferation

Autoimmunity, 2019
Silicosis is an occupational fibrotic lung disease, which is associated with an increased incidence of autoimmune diseases. The effect of crystalline silica on the immune system is thought to be mediated by the antigen presenting cells.
Theodoros Eleftheriadis, Georgios Pissas, Sotirios Zarogiannis, Vassilios Liakopoulos, Ioannis Stefanidis   +4 more
doaj   +1 more source