Results 261 to 270 of about 95,123 (301)

Clustering and Annotation of T Cell Receptor Repertoires

2023
Immunological protection against a wide variety of pathogens is largely mediated by the diverse and dynamic T cell receptor (TCR) repertoire, a crucial component of the adaptive immune system. An encounter with infectious agents stimulates specific T cells to initiate a direct immune response to combat intruders.
Valkiers, Sebastiaan, Gielis, Sofie, Van Deuren, Vincent M.L., Laukens, Kris, Meysman, Pieter   +4 more
openaire   +3 more sources

Flexibility of the T cell receptor repertoire

European Journal of Immunology, 1994
AbstractAlternative T cell receptor (TcR) gene usage between mice of different Mls alleles has been demonstrated in a number of T cell responses. A clear illustration of a flexible TcR Vβ usage in the same strain of mice remains to be established. Using a model system in which I‐Ek‐restricted T cells recognizing λ repressor cI protein (cI) 12–26 and ...
H E, Liang, C C, Chen, D L, Chou, M Z, Lai   +3 more
openaire   +2 more sources

T Cell Receptor Repertoire Sequencing

2020
The status of T cell receptors (TCRs) repertoire is associated with the occurrence and progress of various diseases and can be used in monitoring the immune responses, predicting the prognosis of disease and other medical fields. High-throughput sequencing promotes the studying in TCR repertoire.
Huixin, Lin, Yonggang, Peng, Xiangbin, Chen, Yuebin, Liang, Geng, Tian, Jialiang, Yang   +5 more
openaire   +2 more sources

T Helper Cell Receptors: Idiotypes and Repertoire

Immunological Reviews, 1986
Idiotopes displayed by T cell receptors could be regulatory elements in the selection and maintenance of the T cell repertoire. Among these, of particular interest are those structures which allow receptor-receptor interactions between distinct T cell clonotypes.
G K, Sim, I A, MacNeil, A A, Augustin
openaire   +2 more sources

Identification of Epitope-Specific T Cells in T-Cell Receptor Repertoires

2020
Recognition of cancer epitopes by T cells is fundamental for the activation of targeted antitumor responses. As such, the identification and study of epitope-specific T cells has been instrumental in our understanding of cancer immunology and the development of personalized immunotherapies.
Gielis, Sofie, Moris, Pieter, Bittremieux, Wout, De Neuter, Nicolas, Ogunjimi, Benson, Laukens, Kris, Meysman, Pieter   +6 more
openaire   +3 more sources

Analysis of the T-Cell Receptor Repertoire of Synovial T-Cells

2007
The recognition of a wide diversity of antigens by lymphocytes is made possible by the expression of a large range of highly variable antigen specific receptors, coded for by tandem arrays of genes, which undergo rearrangement during T- and B-cell development.
Lucy R, Wedderburn, Douglas J, King
openaire   +2 more sources

Discrimination of T-cell subsets and T-cell receptor repertoire distribution

Immunologic Research, 2013
Flow cytometry-based analysis of T-cell receptor (TCR) repertoires is an essential tool for the detection of clonal T-cell expansions in physiologic and pathologic conditions. Individual T-cell subsets can be investigated based on their surface properties. The aims of our study were to provide reference values for various disease settings and delineate
Bretschneider, Isabell, Clemente, Michael J., Meisel, Christian, Guerreiro, Manuel, Streitz, Mathias, Hopfenmüller, Werner, Maciejewski, Jaroslaw Pawel, Wlodarski, Marcin W., Volk, Hans-Dieter   +8 more
openaire   +3 more sources

The Repertoire of T-Cell Receptors in Systemic Sclerosis

Critical Reviews™ in Immunology, 1995
Certain T cell subsets are increased in systemic sclerosis patients, particularly V delta 1+ gamma delta T cells in the blood and lungs and CD8+ alpha beta T cells in the lungs. The repertoires of T cell antigen receptor (TCR) V delta 1, V alpha, and V beta gene families were examined by two methods of analysis. First, the relative abundance of V alpha
openaire   +2 more sources

T-cell receptor repertoire usage in hematologic malignancies

Critical Reviews in Oncology/Hematology, 2013
Over the last few years several studies have addressed the possible influence of different immune mechanisms on the evolution of hematologic malignancies. More specifically, a fundamental role of reactive T-cells has now been demonstrated in the pathogenesis of many of these disorders as well as in the typical immunological milieu observed after stem ...
FOZZA, Claudio, Longinotti Maurizio
openaire   +3 more sources

Thymic stromal cell specialization and the T-cell receptor repertoire

Immunologic Research, 1997
Ten years ago, we proposed a model for thymus function in which thymic epithelial cells are primarily responsible for imprinting major histocompatibility complex (MHC)-restricted specificity, and bone marrow-derived macrophages or dendritic cells are responsible for the induction of self-tolerance.
D, Lo, C R, Reilly, L C, Burkly, J, DeKoning, T M, Laufer, L H, Glimcher   +5 more
openaire   +2 more sources