Results 91 to 100 of about 118,951 (307)

A Novel Approach for the Treatment of T Cell Malignancies: Targeting T Cell Receptor Vβ Families

Vaccines, 2020
Peripheral T cell lymphomas (PTCLs) are generally chemotherapy resistant and have a poor prognosis. The lack of targeted immunotherapeutic approaches for T cell malignancies results in part from potential risks associated with targeting broadly expressed
Jie Wang, Katarzyna Urbanska, Prannda Sharma, Reza Nejati, Lauren Shaw, Megan S. Lim, Stephen J. Schuster, Daniel J. Powell Jr.   +7 more
doaj   +1 more source

Correlation Between the Number of T Cell Receptors Required for T Cell Activation and TCR–Ligand Affinity [PDF]

Immunity, 1996
The number of T cell receptors on CTL clone 2C that are required for recognition of various peptide-MHC or superantigen-MHC ligands were measured as a function of both the ligand density on target cells and the binding affinity of the TCR. Quantitative inverse correlations were determined between the number of TCRs required for recognition and the ...
Schodin, Beth A., Tsomides, Theodore J., Kranz, David M.   +2 more
openaire   +2 more sources

Adaptor SKAP-55 binds p21ras activating exchange factor RasGRP1 and negatively regulates the p21ras-ERK pathway in T-Cells [PDF]

, 2008
While the adaptor SKAP-55 mediates LFA-1 adhesion on T-cells, it is not known whether the adaptor regulates other aspects of signaling. SKAP-55 could potentially act as a node to coordinate the modulation of adhesion with downstream signaling.
Lovatt Matt, Christopher E Rudd, Wu, Zhonglin, Schneider, Helga, Rudd Christopher E., Maqueira-Iglesias, Braudel, Matt Lovatt, Schneider Helga, Monika Raab, Valk, Elke, Smith, Xin, Zhonglin Wu, Klaus Strebhardt, Elke Valk, Strebhardt, Klaus, Rudd, Christopher E., Valk Elke, Strebhardt Klaus, Wang Hongyan, Wu Zhonglin, Braudel Maqueira-Iglesias, Maqueira-Iglesias Braudel, Helga Schneider, Xin Smith, Lovatt, Matt, Raab Monika, Raab, Monika, Wang, Hongyan, Smith Xin, Hongyan Wang   +29 more
core   +1 more source

BCMA‐Engineered Dendritic Cell‐Derived Exosomes as Bi‐Functional Therapeutics Orchestrating Cytokine Sequestration and Immune Activation for Multiple Myeloma

Advanced Science, EarlyView.
A dual‐function cell‐free therapeutic based on DC2.4 cell‐derived exosomes engineered to display BCMA. (Left) Soluble Ligand Sequestration (Decoy Function): DB Exo act as molecular decoys that predominantly sequester soluble APRIL with partial BAFF attenuation, effectively disrupting the NF‐κB survival signaling axis and suppressing myeloma cell ...
Yuqing Zeng, Chao He, Zhibin He, Hongbo Chen, Fang Cheng, Yongjiang Zheng   +5 more
wiley   +1 more source

The recent advancement of TCR-T cell therapies for cancer treatment

Acta Biochimica et Biophysica Sinica
Adoptive cell therapies involve infusing engineered immune cells into cancer patients to recognize and eliminate tumor cells. Adoptive cell therapy, as a form of living drug, has undergone explosive growth over the past decade.
Zhao Xiang, Shao Shuai, Hu Lanxin
doaj   +1 more source

Altered proximal T cell receptor (TCR) signaling in human CD4+CD25+ regulatory T cells [PDF]

Journal of Leukocyte Biology, 2006
Abstract CD4+CD25+ regulatory T cells play an important role in peripheral tolerance. Upon T cell receptor (TCR)-mediated activation, the cells fail to proliferate but are induced to have a suppressor function. The intracellular signaling events that lead to their responses have not been elucidated.
Tsang, Julia Yuen-Shan, Camara, Niels Olsen Saraiva, Eren, Efrem, Schneider, Helga, Rudd, Christopher, Lombardi, Giovanna, Lechler, Robert   +6 more
openaire   +3 more sources

Role of regulatory T cells in immune tolerance [PDF]

, 2009
In this present work, we investigated the role of dendritic cells (DC) and regulatory T cells (Treg) in immune tolerance as well as their potential in the treatment of autoimmune or graft versus host (GvH) diseases.
Swee, Lee Kim
core   +1 more source

Neuromorphic Near‐Sensor and In‐Sensor Computing Enabled by Next‐Generation Material‐Based Sensors

Advanced Science, EarlyView.
This Review presents a structural framework that classifies neuromorphic sensing into near‐sensor and in‐sensor architectures, clarifying physical coupling between sensing and computation. The framework connects neural and synaptic device functions with recent advances in optical, mechanical, and chemical sensing, compares energy consumption and ...
Su Yeon Jung, Gwang Ya Kim, Sejin Kim, Hyunjong Seo, Se Gi Lee, Sang Min Won, Dongjoon Rhee, Joohoon Kang   +7 more
wiley   +1 more source

Surface expression of the beta T cell receptor (TCR) chain in the absence of other TCR or CD3 proteins on immature T cells. [PDF]

The EMBO Journal, 1991
T cell receptor (TCR) beta genes are rearranged prior to TCR alpha genes. A productively rearranged TCR beta gene suppresses further V beta gene rearrangement. Here we show that in beta TCR transgenic mice the TCR beta-chain can be expressed on the surface of immature CD4-8- thymocytes, but not on mature T cells, in the absence of any other known TCR ...
H, Kishi, P, Borgulya, B, Scott, K, Karjalainen, A, Traunecker, J, Kaufman, H, von Boehmer   +6 more
openaire   +2 more sources

Combining Radiation‐Treated Tumor Vaccines With Mn‐MOF Nanoadjuvants to Amplify Radiation Induced Anti‐Tumor Immune Responses

Advanced Science, EarlyView.
Radiotherapy‐treated tumor membranes are integrated with Mn‐MOF nanoadjuvants to generate Mn@RM, a lymph node‐draining nanovaccine that delivers radiotherapy‐remodeled antigenic components. Mn@RM enhances dendritic cell activation, amplifies T cell‐mediated antitumor immunity, and synergizes with radiotherapy and PD‐1 blockade for combination cancer ...
Yiyu Wang, Qiqi Qi, Dezhong Li, Jingshi Tang, Weifeng Wang, Zushun Xu, Qi Xu, Fangfang Du, Qianyuan He   +8 more
wiley   +1 more source