Results 171 to 180 of about 1,946,426 (304)

Mapping adaptive immune responses toward fungal antigens in inflammatory bowel disease using T cell repertoire sequencing and phage-immunoprecipitation sequencing. [PDF]

J Crohns Colitis
Mahdy AKH, ElAbd H, Prinzensteiner M, Jebens H, Sivickis K, Bacher P, Vogl T, Poyet M, Franke A.   +8 more
europepmc   +1 more source

T-Cell Repertoire Analysis in the Conjunctiva of Murine Dry Eye Model. [PDF]

Invest Ophthalmol Vis Sci, 2023
Bao X, Zhong Y, Yang C, Chen Y, Han Y, Lin X, Huang C, Wang K, Liu Z, Li C.   +9 more
europepmc   +1 more source

Multiplexed Profiling of Individual Extracellular Vesicles Reveals Lung Cancer‐Associated Protein Signatures

Advanced Science, EarlyView.
Cygnus (Cyclic‐imaging gateway to nanovesicles underlying signature) integrates multiplexed single‐EV protein imaging with a practical analysis workflow to examine EV phenotypes at vesicle, subpopulation, and sample scales. ABSTRACT Lung cancer is frequently diagnosed after curative treatment windows have narrowed, creating a need for minimally ...
Mi Hyeon Cho, Yein Chung, Yoonjeong Choi, Baekdong Cha, Jayeon Song, Nuri Oh, Ala Jo, Thomas S. C. Ng, Hyunho Kim, Hyun‐Kyung Woo, Chang Hyun Kim, Cesar M. Castro, Miles A. Miller, Hakho Lee   +13 more
wiley   +1 more source

T-cell repertoire correlates with cytokine imbalance in multiple sclerosis patients. [PDF]

Front Immunol
Weidner L, Poupardin R, Zrzavy T, Laner-Plamberger S, Gratz G, Eichhorn T, Weber V, Rommer PS, Jungbauer C, Strunk D.   +9 more
europepmc   +1 more source

Risk HLA Variants Affect the T-Cell Repertoire in Multiple Sclerosis. [PDF]

Neurol Neuroimmunol Neuroinflamm, 2023
Sorosina M, Santoro S, Ferrè L, Mascia E, Clarelli F, Giordano A, Cannizzaro M, Lucia M, Martinelli V, Filippi M, Esposito F.   +10 more
europepmc   +1 more source

Supramolecular Degraders: An Emerging Paradigm in Targeted Protein Degradation

Advanced Science, EarlyView.
Dynamic supramolecular assembly reshapes targeted protein degradation by coordinating modular degrader construction, delivery, functional integration, and intracellular assembly or activation across proteasomal, endosomal–lysosomal, and autophagy–lysosomal pathways.
Kongjun Liu, Xue Yuan, Yan Zhou, Rui Yuan, Shaocheng Xie, Yong Chen, Peiyi Wang, Jianmei Gao, Qihai Gong   +8 more
wiley   +1 more source

Age-dependent Zap70 expression in thymocytes regulates selection of the neonatal regulatory T cell repertoire. [PDF]

Nat Immunol
Stadinski BD, Mills EA, Humphries PA, Cleveland SB, Dow P, Murakami K, Li YR, Murakami M, Ono M, Au-Yeung BB, Morris GP, Zúñiga-Pflücker JC, Campbell RA, Griffiths ER, Huseby ES, Lo WL.   +15 more
europepmc   +1 more source

A Synthetic Platform for Antibody Junctional Diversification Beyond Natural Constraints

Advanced Science, EarlyView.
ARESEC is a synthetic platform that reconstructs functional V(D)J recombination in HEK293T cells. By introducing RSS elements and co‐expressing RAG1/2 and TdT across all three antibody CDRs, it enables programmable junctional diversification and direct generation of high‐affinity variants targeting PD‐1/PD‐L1, overcoming the evolutionary constraints of
Wang Liu, Jun Yang, Yuhang Zhang, Xiaoli Xue   +3 more
wiley   +1 more source

Mesoporous PU/PEDOT:PSS Electrodes Reveal Population‐Level Stochastic Bioelectrical Dynamics in Marine Diatoms

Advanced Science, EarlyView.
Mesoporous mixed ionic‐electronic PU/PEDOT: PSS electrodes enable label‐free detection of stochastic extracellular bioelectrical dynamics in living Phaeodactylum tricornutum. Living diatoms actively modulate interfacial ionic dynamics, establishing stochastic electrochemical noise as a sensitive probe of microbial bioelectrochemical activity and a new ...
David M. S. Silva, Felipe L. Bacellar, Raquel Amaral, Louis‐Josselin Lavier‐Aydat, Luísa Cortes, Kamal Asadi, Leïla Tirichine, Paulo R. F. Rocha   +7 more
wiley   +1 more source

Multi-centered T cell repertoire profiling identifies alterations in the immune repertoire of individuals with inflammatory bowel disease across different disease stages. [PDF]

Genome Med
Mahdy AKH, ElAbd H, Kokubun ÉE, Kriukova V, Pesesky M, May DH, Olbjørn C, Perminow G, Bengtson MB, Ricanek P, Andersen S, Detlie TE, Kristensen VA, Moum B, Vatn MH, Jahnsen J, Bokemeyer B, Hov JR, Halfvarson J, Schreiber S, Howie B, Robins HS, Høivik ML, Franke A, IBSEN-III study group.   +24 more
europepmc   +1 more source