Clinical Behavior, Mutational Profile and T-Cell Repertoire of High-Grade Neuroendocrine Tumors of the Head and Neck. [PDF]
Cancers (Basel), 2023 Cabezas-Camarero S +13 more
europepmc +1 more source
Engraftment of sheep splenic lymphocytes into NBSGW mice and application in Brucella infection
Animal Models and Experimental Medicine, EarlyView.A sheep splenocyte‐reconstituted mouse model (Sh‐Spl mice) was established via intravenous injection of sheep splenic lymphocytes into immunodeficient mice to evaluate Brucella infection. Abstract Background The development of immune reconstituted xenograft mouse models has addressed the limitations imposed by interspecies immunological differences in ...
Xiaowei Wang +9 more
wiley +1 more source
Mechanically Interlocked Indigo Photoswitches
Angewandte Chemie, EarlyView.By incorporating indigo photoswitches into the axle of a rotaxane, which features a hydrogen bonding macrocycle, we demonstrate improvement in activation wavelength, photostationary states and thermal reversion, an effect that is governed by topologically constrained supramolecular interactions.
Alexander M. Wilmshurst +9 more
wiley +2 more sources
Evaluation of T-cell repertoire by flow cytometric analysis in primary immunodeficiencies with DNA repair defects. [PDF]
Scand J ImmunolKaraaslan BG +12 more
europepmc +1 more source
T cell Repertoire Profiling and the Mechanism by which HLA-B27 Causes Ankylosing Spondylitis. [PDF]
Curr Rheumatol Rep, 2022 Garrido-Mesa J, Brown MA.
europepmc +1 more source
Advances and perspectives in animal models of human hepatitis A virus
Animal Models and Experimental Medicine, EarlyView.Following HAV infection, humans, non‐human primates, and Ifnar1−/− mice develop characteristic manifestations of hepatitis A, including fecal viral shedding, elevated serum ALT levels, and inflammatory cell infiltration in the liver. In contrast, HAV‐infected human liver chimeric mice exhibit fecal viral shedding but do not develop clinical features of
Jian Li +3 more
wiley +1 more source
Environmental Identification of Novel Enzymes for Polyurethane and Polyamide Degradation
Angewandte Chemie, EarlyView.Heteroatom‐containing plastics such as polyurethanes and nylons are produced at scale yet remain largely unrecycled. Biocatalysts offer a promising route to depolymerization under mild conditions. Here, we present a screening platform for the discovery of novel polyurethane‐ and nylon‐degrading enzymes from environmental samples and demonstrate ...
Malthe Kjær Bendtsen +17 more
wiley +2 more sources
Clinical Features and T-Cell Repertoire of Chronic Myeloid Leukemia Patients Who Attempt Discontinuation of Tyrosine Kinase Inhibitors: The ISAC-TFR Study. [PDF]
Cancer MedUreshino H +6 more
europepmc +1 more source
T-Cell Repertoire in Tumor Radiation: The Emerging Frontier as a Radiotherapy Biomarker. [PDF]
Cancers (Basel), 2022 Baxevanis CN +7 more
europepmc +1 more source
Animal Models and Experimental Medicine, EarlyView.Substantial advances have been achieved in the development of humanized mouse models, which have proven highly valuable in evaluating cancer immunotherapies and elucidating the mechanisms of infectious diseases. There is now a growing shift in research toward larger animal models—such as pigs—that offer greater physiological similarity to humans ...
Yanan Lyu, Yong‐Guang Yang, Zheng Hu
wiley +1 more source