Results 161 to 170 of about 1,946,426 (304)

Phase Separation of TRIM21 Modulates PTPN14 Stability to Drive Flow‐Dependent Endothelial Activation and Atherogenesis

Advanced Science, EarlyView.
Disturbed flow promotes the formation of TRIM21‐rich biomolecular droplets, which concentrate TRIM21 and PTPN14 and facilitate their SPRY‐FERM interaction (illustrated by the TRIM21 D355‐PTPN14 R132 salt bridge). This condensate‐driven proximity enables TRIM21 to catalyze K48‐linked polyubiquitination of PTPN14 at lysine 956, leading to proteasome ...
Xue He, Qiannan Ma, Xue Wang, Jiaxu Mang, Chufeng Li, Bingjun Wu, Liu Yao, Yequn Chen, Qiankun Bao, Yi Zhu, Jinlong He   +10 more
wiley   +1 more source

Inference of SARS-CoV-2 exposure biomarkers using large-scale T-cell repertoire profiling. [PDF]

Genome Med
Vlasova EK, Nekrasova AI, Komkov AY, Izraelson M, Snigir EA, Mitrofanov SI, Yudin VS, Makarov VV, Keskinov AA, Korneeva D, Pivnyuk A, Shelyakin PV, Mamedov IZ, Rebrikov DV, Yudin SM, Skvortsova VI, Chudakov DM, Britanova OV, Shugay M.   +18 more
europepmc   +1 more source

Selective Modulation of OTUB1 Noncanonical Function via a bioPhosTAC Strategy

Advanced Science, EarlyView.
This work positions the versatile performance of the peptide‐based bioPhosTAC platform for dissecting phosphorylation‐dependent biology and expanding the scope of induced‐proximity technologies. We demonstrated that selective manipulation of a tyrosine phosphorylation site is sufficient to propagate coordinated cellular consequences.
Seung Un Seo, Seon Min Woo, Minhyeong Choi, Soeun Rhee, Simmyung Yook, Donghyuk Shin, Kwang‐Su Park, Taeg Kyu Kwon   +7 more
wiley   +1 more source

Delineation and monitoring of the T cell repertoire of adoptive cell transfer product during the treatment of advanced melanoma. [PDF]

Genome Med
Kerr C, Soleimani S, Mulder DT, Nabbi A, Gray D, Pedersen S, Sotov V, Sudhaman S, Nguyen L, Hirano N, Ohashi PS, Butler MO, Pugh TJ.   +12 more
europepmc   +1 more source

Nicotinamide Metabolism Constrains Memory CD8+ T Cell Formation Through a Putative HS1BP3‐SIRT1‐FOXO3‐BCL6 Axis

Advanced Science, EarlyView.
ABSTRACT Memory T cells exhibit long‐term persistence, a defining feature that underpins durable clinical responses to adoptive immunotherapies. The mechanisms that integrate metabolic cues with transcriptional control of memory fate remain undetermined. Here, we identify HS1‐binding protein 3 (HS1BP3) is preferentially expressed in memory CD8+ T cells.
Siyang Wang, Xiaoqian Fan, Yifan Huang, Chang Yao, Jixing Fan, Yu Ping, Xuan Zhao, Congcong Li, Chunyi Shen, Jiqi Shan, Jinyan Liu, Shengdian Wang, Zhen Zhang, Yi Zhang   +13 more
wiley   +1 more source

269 CAR T cell production expands endogenous T cell repertoire recognizing additional tumor antigen(s)

Journal for ImmunoTherapy of Cancer, 2023
Duane A Mitchell, Jianping Huang, Alicia Hou, Linchun Jin, Haipeng Tao   +4 more
doaj   +1 more source

Quantitative evaluation of T-cell repertoire restoration following hematopoietic stem cell transplantation in patients with and without graft versus host disease. [PDF]

Front Immunol
Zhang X, Song P, Tang L, Ji X, Hu X, Ma X, Chen F, He X, Wang J, Li W, Qiu H, Xue S, Wang Y, Miao M, Chen S, Wu D, Tang X, Wang M, Wang W, Tian X.   +19 more
europepmc   +1 more source

Tissue-specific features of the T cell repertoire after allogeneic hematopoietic cell transplantation in human and mouse. [PDF]

Sci Transl Med, 2023
DeWolf S, Elhanati Y, Nichols K, Waters NR, Nguyen CL, Slingerland JB, Rodriguez N, Lyudovyk O, Giardina PA, Kousa AI, Andrlová H, Ceglia N, Fei T, Kappagantula R, Li Y, Aleynick N, Baez P, Murali R, Hayashi A, Lee N, Gipson B, Rangesa M, Katsamakis Z, Dai A, Blouin AG, Arcila M, Masilionis I, Chaligne R, Ponce DM, Landau HJ, Politikos I, Tamari R, Hanash AM, Jenq RR, Giralt SA, Markey KA, Zhang Y, Perales MA, Socci ND, Greenbaum BD, Iacobuzio-Donahue CA, Hollmann TJ, van den Brink MRM, Peled JU.   +43 more
europepmc   +1 more source

Aging‐related changes in human T‐cell repertoire over 20 years delineated by deep sequencing of peripheral T‐cell receptors

Experimental Gerontology, 2017
K. Yoshida, J. Cologne, Kismet Cordova, Munechika Misumi, Mika Yamaoka, S. Kyoizumi, T. Hayashi, H. Robins, Y. Kusunoki   +8 more
semanticscholar   +1 more source

Switching Spike Plasticity Shapes ACE2 Engagement Across SARS‐CoV‐2 Variants

Advanced Science, EarlyView.
Conformational plasticity governs SARS‐CoV‐2 spike function and ACE2 recognition. Using high‐speed AFM and single‐molecule force spectroscopy, we analyzed the ancestral spike and nine variants, revealing progressive rigidification from Delta, variable plasticity in Omicron sublineages, and JN.1 compaction.
Sarah Stainer, Rong Zhu, Manuel Reithofer, Gerhard Stadlmayr, Katharina Stadlbauer, Panchika Prangkio, Christoph Rippel, Markus Hahn, Aniko Eva Kasztner, Stefanie Stohl, Petr Bednar, Daniel Ruzek, David Glück, Robert Tampé, Gordana Wozniak‐Knopp, Yoo Jin Oh, Miriam Klausberger, Peter Hinterdorfer   +17 more
wiley   +1 more source