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Topological Quantum Biomaterials Enable Pyroptosis‐Senescence Coupling for Enhanced Colorectal Cancer Therapy

Advanced Science, EarlyView.
This work reports conceptually unprecedented topological quantum biomaterials derived from engineered Pd3Sn nanostrips for oncological applications. Their near‐Fermi‐level electronic architecture and superior interfacial charge transport facilitate ultrasound‐amplified redox reactions and efficient ROS generation.
Zilu Chen, Kun Mei, Yan Yang, Mengna Xu, Xinyue Dai, Renjun Gu, Fuqiong Zhou, Cheng Wang, Meiqi Chang, Yan Huang, Yu Chen   +10 more
wiley   +1 more source

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T-Cell Repertoire Characterization

Methods in Molecular Biology, 2022
T-cell repertoire characterization is a methodology that enables the identification of T-cell receptor (TCR) gene sequences in a T-cell population. TCR genes are composed of modular gene segments V (D) J that undergo somatic recombination, resulting in unique and unpredictable sequences that can be utilized to identify each T-cell clone.
Anna, Pasetto, Marcus, Buggert
semanticscholar   +4 more sources

Peripheral Selection of the T Cell Repertoire

Science, 1991
T lymphocytes undergo selection events not only in the thymus, but also after they leave the thymus and reside in the periphery. Peripheral selection was found to be dependent on T cell receptor (TCR)-ligand interactions but to differ from thymic selection with regard to specificity and mechanism.
B, Rocha, H, von Boehmer
openaire   +3 more sources

Allelic variation in class I HLA determines CD8+ T cell repertoire shape and cross-reactive memory responses to SARS-CoV-2

Science immunology, 2021
Effective presentation of antigens by human leukocyte antigen (HLA) class I molecules to CD8+ T cells is required for viral elimination and generation of long-term immunological memory.
J. Francis, Del Leistritz-Edwards, A. Dunn, C. Tarr, J. Lehman, Conor Dempsey, A. Hamel, Violeta Rayon, Gang Liu, Yuntong Wang, Marcos Wille, Melissa Durkin, Kane Hadley, A. Sheena, Benjamin P. Roscoe, M. Ng, Graham Rockwell, Margaret Manto, Elizabeth Gienger, Joshua Nickerson, Amir Moarefi, M. Noble, T. Malia, P. Bardwell, W. Gordon, Joanna Swain, M. Škoberne, K. Sauer, Tim Harris, Ananda W. Goldrath, A. Shalek, A. Coyle, C. Benoist, D. Pregibon, N. Jilg, Jonathan Z. Li, A. Rosenthal, C. Wong, George Daley, D. Golan, H. Heller, A. Sharpe, Betelihem A. Abayneh, Patrick Allen, Diane Antille, K. Armstrong, Siobhan Boyce, J. Braley, Karen Branch, Katherine Broderick, J. Carney, Andrew Chan, Susan P Davidson, M. Dougan, D. Drew, Ashley Elliman, K. Flaherty, J. Flannery, Pamela J Forde, E. Gettings, Amanda J. Griffin, S. Grimmel, Kathleen A. Grinke, K. Hall, Michael D Healy, Deborah Henault, Grace Holland, Chantal Kayitesi, V. LaValle, Yuting Lu, Sarah Luthern, Jordan Schneider, Brittani Martino, R. McNamara, Christian Nambu, S. Nelson, M. Noone, Christine Ommerborn, Lois Chris Pacheco, Nicole Phan, Falisha A Porto, E. Ryan, K. Selleck, Sue Slaughenhaupt, K. Sheppard, Elizabeth Suschana, Viv J. Wilson, Mary Carrington, Maureen P. Martin, Y. Yuki, G. Alter, A. Balazs, J. Bals, M. Barbash, Y. Bartsch, J. Boucau, Joshua M. Chevalier, Fatema Z. Chowdhury, Edward DeMers, K. Einkauf, John Fallon, Liz Fedirko, Kelsey K. Finn, Pilar Garcia-Broncano, M. Ghebremichael, C. Hartana, Chen-yang Jiang, Kelly A. Judge, P. Kaplonek, Marshall Karpell, Peggy S. Lai, Evan C. Lam, Kristina Lefteri, X. Lian, M. Lichterfeld, D. Lingwood, Hang Liu, Jin-Qing Liu, N. Ly, Z. Hill, Ashlin R. Michell, Ilan Millstrom, Noah Miranda, C. O’Callaghan, Matt Osborn, S. Pillai, Yelizaveta Rassadkina, Alexandra Reissis, Francis Ruzicka, Kyra W. Seiger, Libera Sessa, C. Sharr, Sally A. Shin, Nishant Singh, Wei-Wei Sun, Xiao-Ming Sun, Hannah Ticheli, Alicja Trocha-Piechocka, B. Walker, D. Worrall, Xu G. Yu, A. Zhu   +141 more
semanticscholar   +1 more source

Flexibility of the T cell receptor repertoire

European Journal of Immunology, 1994
AbstractAlternative T cell receptor (TcR) gene usage between mice of different Mls alleles has been demonstrated in a number of T cell responses. A clear illustration of a flexible TcR Vβ usage in the same strain of mice remains to be established. Using a model system in which I‐Ek‐restricted T cells recognizing λ repressor cI protein (cI) 12–26 and ...
H E, Liang, C C, Chen, D L, Chou, M Z, Lai   +3 more
openaire   +2 more sources

T Cell Repertoire in Systemic Sclerosis

International Reviews of Immunology, 1995
An increase of certain T cell subsets in systemic sclerosis patients, particularly of V delta 1+ gamma delta T cells in the blood and lungs and CD8+ alpha beta T cells in the lungs, has been shown. The diversity of T cell antigen receptor (TCR) V delta 1, V alpha, and V beta gene repertoires was examined using reverse transcriptase-polymerase chain ...
V V, Yurovsky, B, White
openaire   +2 more sources

T Cell Receptor Repertoire Sequencing

2020
The status of T cell receptors (TCRs) repertoire is associated with the occurrence and progress of various diseases and can be used in monitoring the immune responses, predicting the prognosis of disease and other medical fields. High-throughput sequencing promotes the studying in TCR repertoire.
Huixin, Lin, Yonggang, Peng, Xiangbin, Chen, Yuebin, Liang, Geng, Tian, Jialiang, Yang   +5 more
openaire   +2 more sources

The T-cell repertoire for antigen and MHC

Immunology Today, 1988
Abstract The repertoire for antigen bound to self major histocompatibility complex (MHC) proteins of peripheral T cells in a given animal is controlled in several ways: by the collection of germ-line genes available in the animal; by removal of self-reactive cells during tolerance induction; and by positive selection of cells bearing receptors biased ...
P, Marrack, J, Kappler
openaire   +2 more sources

Clustering and Annotation of T Cell Receptor Repertoires

2023
Immunological protection against a wide variety of pathogens is largely mediated by the diverse and dynamic T cell receptor (TCR) repertoire, a crucial component of the adaptive immune system. An encounter with infectious agents stimulates specific T cells to initiate a direct immune response to combat intruders.
Valkiers, Sebastiaan, Gielis, Sofie, Van Deuren, Vincent M.L., Laukens, Kris, Meysman, Pieter   +4 more
openaire   +3 more sources

T cell repertoire and autoimmune diseases

Immunologic Research, 1993
Self-reactivity and autoimmunity are processes related to the breakage of self-tolerance that can be distinguished by their different clinical outcome and are widely accepted cornerstones of immunology. The finding that several potentially autoaggressive cells contribute to the repertoire of healthy individuals has stimulated a great deal of ...
L, Imberti, A, Sottini, D, Primi
openaire   +2 more sources