Results 251 to 260 of about 1,946,426 (304)
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Shaping the T‐cell repertoire in the periphery
Immunology & Cell Biology, 2010Selection of T cells does not end with events in the thymus, but continues in extrathymic tissues and for the life of the organism. In this review, we examine how self‐reactive T cells are rendered harmless and the processes that select for T cells that are most efficient at combating pathogens.
Stacey, Allen +4 more
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1997
The prevailing concept about a major influence of thymic positive selection on shaping the T cell repertoire during ontogeny is confronted with an old idea emphasizing a dominant role for genetic (evolutionary) factors in molding the recognition potential of mature T cells.
Vidovic, D +3 more
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The prevailing concept about a major influence of thymic positive selection on shaping the T cell repertoire during ontogeny is confronted with an old idea emphasizing a dominant role for genetic (evolutionary) factors in molding the recognition potential of mature T cells.
Vidovic, D +3 more
openaire +1 more source
Analysis of the T-Cell Receptor Repertoire of Synovial T-Cells
2007The recognition of a wide diversity of antigens by lymphocytes is made possible by the expression of a large range of highly variable antigen specific receptors, coded for by tandem arrays of genes, which undergo rearrangement during T- and B-cell development.
Lucy R, Wedderburn, Douglas J, King
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Identification of Epitope-Specific T Cells in T-Cell Receptor Repertoires
2020Recognition of cancer epitopes by T cells is fundamental for the activation of targeted antitumor responses. As such, the identification and study of epitope-specific T cells has been instrumental in our understanding of cancer immunology and the development of personalized immunotherapies.
Gielis, Sofie +6 more
openaire +4 more sources
Control of the T Cell Repertoire
1993T cell receptors for antigen bound to Major histocompatibility complex proteins (MHC) are made up of a number of different variable elements, Vα, Jα, V² and so on. Although any given mouse or man can probably make at least 1010 different versions of these receptors it is certain that not all possible combinations are expressed in any given animal.
P. Marrack +6 more
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Stem cell reconstitution of autoimmune T cell repertoires
Journal of Neuroimmunology, 2005Maintenance of T cell memory in autoimmune disease may be complex because the unending renewable supply of self provides an inherent high antigen load that effectively precludes clearance, and because the broad array of potential immunogenic targets provides extensive self-recognition plasticity.
Andrea E, Edling, Vincent K, Tuohy
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1985
The T-cell repertoire is built on the following elements 1) available germ-lines genes, allowing diversity of antigen receptors on T cells, 2) available class I and class II MLC restriction elements, 3) the need for tolerance of self structures and 4) other genetically determined immune mechanisms tuning the T-cell repertoire, 5) diversification due to
A. Moretta, C. J. M. Melief
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The T-cell repertoire is built on the following elements 1) available germ-lines genes, allowing diversity of antigen receptors on T cells, 2) available class I and class II MLC restriction elements, 3) the need for tolerance of self structures and 4) other genetically determined immune mechanisms tuning the T-cell repertoire, 5) diversification due to
A. Moretta, C. J. M. Melief
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Discrimination of T-cell subsets and T-cell receptor repertoire distribution
Immunologic Research, 2013Flow cytometry-based analysis of T-cell receptor (TCR) repertoires is an essential tool for the detection of clonal T-cell expansions in physiologic and pathologic conditions. Individual T-cell subsets can be investigated based on their surface properties. The aims of our study were to provide reference values for various disease settings and delineate
Bretschneider, Isabell +8 more
openaire +3 more sources
1994
Crohn’s disease and ulcerative colitis are characterized by chronic intestinal inflammation of unknown etiology. It has been proposed that, in an individual with the appropriate genetic background, exposure to environmental agents or organisms leads to activation of intestinal immune cells and chronic inflammation.
K. Croitoru +2 more
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Crohn’s disease and ulcerative colitis are characterized by chronic intestinal inflammation of unknown etiology. It has been proposed that, in an individual with the appropriate genetic background, exposure to environmental agents or organisms leads to activation of intestinal immune cells and chronic inflammation.
K. Croitoru +2 more
openaire +1 more source
Self-Tolerance and the Composition of T Cell Repertoire
Immunologic Research, 2000T cell recognition of self-major histocompatibility complex-peptide complexes dictates the composition of the T cell receptor repertoire. Research projects in our laboratory deal with the mechanisms that regulate the composition of the repertoire specific for self-antigens and the defects that can result in autoimmunity.
L A, Sherman +7 more
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