Results 251 to 260 of about 144,479 (301)

The T-cell repertoire for antigen and MHC

Immunology Today, 1988
Abstract The repertoire for antigen bound to self major histocompatibility complex (MHC) proteins of peripheral T cells in a given animal is controlled in several ways: by the collection of germ-line genes available in the animal; by removal of self-reactive cells during tolerance induction; and by positive selection of cells bearing receptors biased ...
P, Marrack, J, Kappler
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T cell repertoire and autoimmune diseases

Immunologic Research, 1993
Self-reactivity and autoimmunity are processes related to the breakage of self-tolerance that can be distinguished by their different clinical outcome and are widely accepted cornerstones of immunology. The finding that several potentially autoaggressive cells contribute to the repertoire of healthy individuals has stimulated a great deal of ...
L, Imberti, A, Sottini, D, Primi
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T Cell Receptor Repertoire Sequencing

2020
The status of T cell receptors (TCRs) repertoire is associated with the occurrence and progress of various diseases and can be used in monitoring the immune responses, predicting the prognosis of disease and other medical fields. High-throughput sequencing promotes the studying in TCR repertoire.
Huixin, Lin, Yonggang, Peng, Xiangbin, Chen, Yuebin, Liang, Geng, Tian, Jialiang, Yang   +5 more
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Clustering and Annotation of T Cell Receptor Repertoires

2023
Immunological protection against a wide variety of pathogens is largely mediated by the diverse and dynamic T cell receptor (TCR) repertoire, a crucial component of the adaptive immune system. An encounter with infectious agents stimulates specific T cells to initiate a direct immune response to combat intruders.
Valkiers, Sebastiaan, Gielis, Sofie, Van Deuren, Vincent M.L., Laukens, Kris, Meysman, Pieter   +4 more
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Shaping the T‐cell repertoire in the periphery

Immunology & Cell Biology, 2010
Selection of T cells does not end with events in the thymus, but continues in extrathymic tissues and for the life of the organism. In this review, we examine how self‐reactive T cells are rendered harmless and the processes that select for T cells that are most efficient at combating pathogens.
Stacey, Allen, Stephen J, Turner, Dorothée, Bourges, Paul A, Gleeson, Ian R, van Driel   +4 more
openaire   +2 more sources

Peripheral Selection of the T Cell Repertoire

Science, 1991
T lymphocytes undergo selection events not only in the thymus, but also after they leave the thymus and reside in the periphery. Peripheral selection was found to be dependent on T cell receptor (TCR)-ligand interactions but to differ from thymic selection with regard to specificity and mechanism.
B, Rocha, H, von Boehmer
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Analysis of the T-Cell Receptor Repertoire of Synovial T-Cells

2007
The recognition of a wide diversity of antigens by lymphocytes is made possible by the expression of a large range of highly variable antigen specific receptors, coded for by tandem arrays of genes, which undergo rearrangement during T- and B-cell development.
Lucy R, Wedderburn, Douglas J, King
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Identification of Epitope-Specific T Cells in T-Cell Receptor Repertoires

2020
Recognition of cancer epitopes by T cells is fundamental for the activation of targeted antitumor responses. As such, the identification and study of epitope-specific T cells has been instrumental in our understanding of cancer immunology and the development of personalized immunotherapies.
Gielis, Sofie, Moris, Pieter, Bittremieux, Wout, De Neuter, Nicolas, Ogunjimi, Benson, Laukens, Kris, Meysman, Pieter   +6 more
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Stem cell reconstitution of autoimmune T cell repertoires

Journal of Neuroimmunology, 2005
Maintenance of T cell memory in autoimmune disease may be complex because the unending renewable supply of self provides an inherent high antigen load that effectively precludes clearance, and because the broad array of potential immunogenic targets provides extensive self-recognition plasticity.
Andrea E, Edling, Vincent K, Tuohy
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Discrimination of T-cell subsets and T-cell receptor repertoire distribution

Immunologic Research, 2013
Flow cytometry-based analysis of T-cell receptor (TCR) repertoires is an essential tool for the detection of clonal T-cell expansions in physiologic and pathologic conditions. Individual T-cell subsets can be investigated based on their surface properties. The aims of our study were to provide reference values for various disease settings and delineate
Bretschneider, Isabell, Clemente, Michael J., Meisel, Christian, Guerreiro, Manuel, Streitz, Mathias, Hopfenmüller, Werner, Maciejewski, Jaroslaw Pawel, Wlodarski, Marcin W., Volk, Hans-Dieter   +8 more
openaire   +3 more sources