Results 261 to 270 of about 144,479 (301)

Antigen-Driven T-Cell Repertoire Selection

Critical Reviews in Immunology, 2005
The immune system has evolved to combat infectious organisms through the coordination of both innate and acquired immune responses. Innate immune responses generally pass their roles in eradicating pathogens to acquired immune responses conducted by T and B cells. T and B cells generate diverse antigen-specific receptors through gene recombination, and
Yoichi, Maekawa, Koji, Yasutomo
openaire   +2 more sources

Self-Tolerance and the Composition of T Cell Repertoire

Immunologic Research, 2000
T cell recognition of self-major histocompatibility complex-peptide complexes dictates the composition of the T cell receptor repertoire. Research projects in our laboratory deal with the mechanisms that regulate the composition of the repertoire specific for self-antigens and the defects that can result in autoimmunity.
L A, Sherman, D J, Morgan, C T, Nugent, F J, Hernandez, H T, Kreuwel, A, Murtaza, A, Ko, J, Biggs   +7 more
openaire   +2 more sources

T cell repertoire and IBD

1994
Crohn’s disease and ulcerative colitis are characterized by chronic intestinal inflammation of unknown etiology. It has been proposed that, in an individual with the appropriate genetic background, exposure to environmental agents or organisms leads to activation of intestinal immune cells and chronic inflammation.
K. Croitoru, D. K. H. Wong, M. E. Baca-Estrada   +2 more
openaire   +1 more source

Control of the T Cell Repertoire

1993
T cell receptors for antigen bound to Major histocompatibility complex proteins (MHC) are made up of a number of different variable elements, Vα, Jα, V² and so on. Although any given mouse or man can probably make at least 1010 different versions of these receptors it is certain that not all possible combinations are expressed in any given animal.
P. Marrack, J. H. Freed, L. Ignatowitz, J. McComarck, J. Callahan, P. Hugo, J. W. Kappler   +6 more
openaire   +1 more source

Probing the T-Cell Repertoire

1985
The T-cell repertoire is built on the following elements 1) available germ-lines genes, allowing diversity of antigen receptors on T cells, 2) available class I and class II MLC restriction elements, 3) the need for tolerance of self structures and 4) other genetically determined immune mechanisms tuning the T-cell repertoire, 5) diversification due to
A. Moretta, C. J. M. Melief
openaire   +1 more source

T Cell Migration During Ontogeny and T Cell Repertoire Generation

1996
Before their hematopoietic stem cell origin was recognized, chicken thymocytes were thought to be derived from epithelial precursors in the thymus that could be converted into lymphocytes under the influence of surrounding mesenchymal tissue (Auerbach 1961).
D, Dunon, B A, Imhof
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T‐Cell Specificity and Repertoire

Immunological Reviews, 1988
M A, Blackman, J W, Kappler, P, Marrack
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The Repertoire of T-Cell Receptors in Systemic Sclerosis

Critical Reviews™ in Immunology, 1995
Certain T cell subsets are increased in systemic sclerosis patients, particularly V delta 1+ gamma delta T cells in the blood and lungs and CD8+ alpha beta T cells in the lungs. The repertoires of T cell antigen receptor (TCR) V delta 1, V alpha, and V beta gene families were examined by two methods of analysis. First, the relative abundance of V alpha
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Memory B cell repertoire for recognition of evolving SARS-CoV-2 spike

Cell, 2021
Pei Tong, Avneesh Gautam, Ian W Windsor   +2 more
exaly  

Thymic selection of the T-cell repertoire

Immunologic Research, 1988
Kruisbeek, A, Zúñiga Pflücker, J, Marusić Galesić, S, Weston, M, TENTORI, LUCIO, Longo, D.   +5 more
openaire   +3 more sources