Results 251 to 260 of about 56,239 (298)
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T Cell Repertoire in Systemic Sclerosis
International Reviews of Immunology, 1995An increase of certain T cell subsets in systemic sclerosis patients, particularly of V delta 1+ gamma delta T cells in the blood and lungs and CD8+ alpha beta T cells in the lungs, has been shown. The diversity of T cell antigen receptor (TCR) V delta 1, V alpha, and V beta gene repertoires was examined using reverse transcriptase-polymerase chain ...
V V, Yurovsky, B, White
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Repertoire Remodeling through CD4+ T-cell Depletion
Cancer Immunology Research, 2021Abstract Understanding the cellular regulation of tumor-specific CD8+ T-cell responses is critical to designing improved clinical strategies for cancer immunotherapy. In this issue, Aoki and colleagues deepen our knowledge of this topic by demonstrating that transient depletion of CD4+ T cells in patients with gastrointestinal cancer ...
Winnie Yao, Ansuman T. Satpathy
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T cell repertoire and autoimmune diseases
Immunologic Research, 1993Self-reactivity and autoimmunity are processes related to the breakage of self-tolerance that can be distinguished by their different clinical outcome and are widely accepted cornerstones of immunology. The finding that several potentially autoaggressive cells contribute to the repertoire of healthy individuals has stimulated a great deal of ...
L, Imberti, A, Sottini, D, Primi
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Stem cell reconstitution of autoimmune T cell repertoires
Journal of Neuroimmunology, 2005Maintenance of T cell memory in autoimmune disease may be complex because the unending renewable supply of self provides an inherent high antigen load that effectively precludes clearance, and because the broad array of potential immunogenic targets provides extensive self-recognition plasticity.
Andrea E, Edling, Vincent K, Tuohy
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Identification of Epitope-Specific T Cells in T-Cell Receptor Repertoires
2020Recognition of cancer epitopes by T cells is fundamental for the activation of targeted antitumor responses. As such, the identification and study of epitope-specific T cells has been instrumental in our understanding of cancer immunology and the development of personalized immunotherapies.
Gielis, Sofie +6 more
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Peripheral Selection of the T Cell Repertoire
Science, 1991T lymphocytes undergo selection events not only in the thymus, but also after they leave the thymus and reside in the periphery. Peripheral selection was found to be dependent on T cell receptor (TCR)-ligand interactions but to differ from thymic selection with regard to specificity and mechanism.
B, Rocha, H, von Boehmer
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T Cell Receptor Repertoire in Rheumatoid Arthritis
International Reviews of Immunology, 1998CD4+ T cells are a major component of the inflammatory infiltrate in rheumatoid synovitis. Within synovial lesions, clonal CD4+ T cell populations are detectable, supporting the notion of an antigen specific recognition even in the joint. In general, the clonal size of individual T cell clones is small and does not lead to a marked distortion of the ...
J J, Goronzy, A, Zettl, C M, Weyand
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T Cell Migration During Ontogeny and T Cell Repertoire Generation
1996Before their hematopoietic stem cell origin was recognized, chicken thymocytes were thought to be derived from epithelial precursors in the thymus that could be converted into lymphocytes under the influence of surrounding mesenchymal tissue (Auerbach 1961).
D, Dunon, B A, Imhof
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Flexibility of the T cell receptor repertoire
European Journal of Immunology, 1994AbstractAlternative T cell receptor (TcR) gene usage between mice of different Mls alleles has been demonstrated in a number of T cell responses. A clear illustration of a flexible TcR Vβ usage in the same strain of mice remains to be established. Using a model system in which I‐Ek‐restricted T cells recognizing λ repressor cI protein (cI) 12–26 and ...
H E, Liang +3 more
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1985
The T-cell repertoire is built on the following elements 1) available germ-lines genes, allowing diversity of antigen receptors on T cells, 2) available class I and class II MLC restriction elements, 3) the need for tolerance of self structures and 4) other genetically determined immune mechanisms tuning the T-cell repertoire, 5) diversification due to
A. Moretta, C. J. M. Melief
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The T-cell repertoire is built on the following elements 1) available germ-lines genes, allowing diversity of antigen receptors on T cells, 2) available class I and class II MLC restriction elements, 3) the need for tolerance of self structures and 4) other genetically determined immune mechanisms tuning the T-cell repertoire, 5) diversification due to
A. Moretta, C. J. M. Melief
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