Results 261 to 270 of about 27,710,413 (387)

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Neonatal Regulatory T Cells Mediate Fibrosis and Contribute to Cardiac Repair. [PDF]

Cells
Kino T, Mohsin S, Chiba Y, Sugiyama M, Ishigami T.   +4 more
europepmc   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Antigen reactivity defines tissue-resident memory and exhausted T cells in tumors. [PDF]

Nat Immunol
Burn TN, Schröder J, Gandolfo LC, Osman M, Wainwright EN, Lam EYN, McDonald KM, Evans RB, Li S, Rawlinson D, Dryburgh L, Zaid A, Maliga Z, Schienstock D, Meiser P, Lee HJ, Lai H, Moreira ML, Zareie P, Lee LH, Huq L, Christo SN, Seow JJW, Ching KA, Guillaume SM, Knezevic K, Park SL, Evrard M, Waithman J, Gebhardt T, Mueller SN, Riddiough GE, Perini MV, Tsao SCH, Speed TP, Sorger PK, Loi S, Carbone FR, Gras S, Fisher TS, Baaten BJ, Dawson MA, Mackay LK.   +42 more
europepmc   +1 more source

IL-7 promotes naïve T cell motility to enable T cell scanning of dendritic cells in the LN

Janie R. Byrum, Kimberly A. Morrissey, David J. Torres, Sreenivasa Rao Oruganti, Judy L. Cannon   +4 more
openalex   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Small-molecule control of CAR T cells. [PDF]

Nat Rev Chem
Adams EL, McGovern AC, So V, Srinivasan S, Deiters A, Lohmueller J.   +5 more
europepmc   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Haematopoietic stem cell transplantation for cutaneous T‐cell lymphomas: Decision‐guiding prognostic determinants yet to be clarified [PDF]

Marion Wobser
openalex   +1 more source

TOX reinforces the phenotype and longevity of exhausted T cells in chronic viral infection

Nature, 2019
Francesca Alfei, Kristiyan Kanev, M. Hofmann, Ming Wu, Hazem E. Ghoneim, Patrick Roelli, Daniel T. Utzschneider, Madlaina von Hoesslin, Jolie G. Cullen, Yiping Fan, Vasyl Eisenberg, D. Wohlleber, K. Steiger, D. Merkler, M. Delorenzi, P. Knolle, C. Cohen, R. Thimme, Ben Youngblood, D. Zehn   +19 more
semanticscholar   +1 more source