Results 161 to 170 of about 13,929,988 (284)

Differential generation of parasite-specific Th2 and T follicular helper cells distinguishes resistant and susceptible mouse strains. [PDF]

Front Immunol
Zhang H, Adjah J, Kapse B, Affinass N, Ebner F, Hartmann S, Rausch S.   +6 more
europepmc   +1 more source

Distinct Molecular Pathways Supporting Sjögren Disease Clusters and Disease Progression

Arthritis &Rheumatology, EarlyView.
Objective Sjögren disease (SjD) is a heterogeneous autoimmune disease. We aimed to investigate blood transcriptomic signatures and disease progression among three recently defined clusters of patients with SjD: (1) B cell active disease with low symptom burden (BALS), (2) high systemic activity (HSA), and (3) low systemic activity with high symptom ...
Sacha E. Silva‐Saffar, Yann Nguyen, Raphaèle Seror, Jacques‐Eric Gottenberg, Anna Niarakis, Xavier Mariette, Gaetane Nocturne   +6 more
wiley   +1 more source

DGKα and ζ deficiency causes regulatory T-cell dysregulation, destabilization, and conversion to pathogenic T-follicular helper cells to trigger IgG1-predominant autoimmunity. [PDF]

Elife
Li L, Huang H, Wang H, Pan Y, Tao H, Zhang S, Karmaus P, Fessler MB, Sleasman J, Zhong XP.   +9 more
europepmc   +1 more source

Follicular helper T cells in autoimmune diseases [PDF]

Rheumatology, 2014
Gábor, Papp, Krisztina, Szabó, Zoltán, Szekanecz, Margit, Zeher   +3 more
openaire   +2 more sources

Dnmt3a Mutations Limit Normal and Autoreactive CD4+ T Follicular Helper Responses and Attenuate T Cell–Driven Joint Inflammation

Arthritis &Rheumatology, EarlyView.
Objective Somatic DNMT3A mutations are the most common drivers of clonal hematopoiesis in patients with rheumatoid arthritis (RA) and have been associated with seropositive disease and increased markers of inflammation. These mutations are predominantly hypomorphic or dominant‐negative, reducing DNMT3A function.
Yunbing Shen, Sanjaykumar Boddul, Zhaojun Li, Zsolt Kasza, Marlene Schülein, Bruno Raposo, Karine Chemin, Per‐Johan Jakobsson, Alexander Espinosa, Lars Klareskog, Fredrik Wermeling   +10 more
wiley   +1 more source

Deep Immunophenotyping Reveals Distinct Immune Signatures in Axial Spondyloarthritis and Psoriatic Arthritis

Arthritis &Rheumatology, EarlyView.
Objective Axial spondyloarthritis (axSpA) and psoriatic arthritis (PsA) are overlapping yet distinct conditions within the SpA spectrum. As divergent immunophenotypes may influence disease course and therapeutic response, we compared immune cell subsets, cytokine profiles, and inflammatory mediators.
Natalie Frede, Nils Craig‐Müller, Silke Kohrt, Marei‐Theresa Bott, Ulrich Salzer, Ana Cecilia Venhoff, Jens Thiel, Julia Frede, Reinhard E. Voll, Marta Rizzi, Raquel Lorenzetti, Nils Venhoff   +11 more
wiley   +1 more source

Editorial: CD4 T Follicular Helper Cells in HIV

Frontiers in Immunology, 2017
Smita S. Iyer
doaj   +1 more source

DOCK8 and STAT3 cooperate to restrain IgE-inducing T follicular helper cells. [PDF]

J Exp Med
Siniscalco ER, Fisher C, Lu MP, Grassmann JDS, Mack CD, Yaakoubi R, Jacobsen D, Chen Q, Lee D, Rajamanimuthu P, Simoneau T, Preece K, Gray P, Okada S, Boisson B, Kayaoglu B, Danielson J, Freeman AF, Casanova JL, Chatila TA, Su HC, Ma CS, Williams A, Eisenbarth SC, Gowthaman U.   +24 more
europepmc   +1 more source

Age‐Associated B Cells Contribute to Inflammation Via Antibody‐Independent Mechanisms in Takayasu Arteritis

Arthritis &Rheumatology, EarlyView.
Objective Although Takayasu arteritis (TAK) is not a prototypical autoantibody‐mediated disease, accumulating evidence suggests that B cells are involved. This study aimed to investigate the pathway of B cell activation and its contributions to TAK pathogenesis. Methods Histologic analysis of paravascular lymph nodes and affected arteries was conducted
Chenglong Fang, Xiaoxi Yang, Xiaochuan Sun, Shangyi Jin, Lihong Du, Jinwei Gao, Jing Li, Zhen Chen, Yuexin Chen, Mengtao Li, Xinping Tian   +10 more
wiley   +1 more source

AhR agonist Ficz modulates T follicular helper cells and ameliorates skin fibrosis in a bleomycin-induced SSc mouse model. [PDF]

J Scleroderma Relat Disord
Zhu X, Chen Y, Qiu C, Wei M, Chen J, Luo B, Qi Q.   +6 more
europepmc   +1 more source