Results 171 to 180 of about 67,870 (201)
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Follicular helper T cells in rheumatoid arthritis
Clinical Rheumatology, 2015Rheumatoid arthritis (RA) is an autoimmune disease characterized by chronic inflammation in the joints and other tissues. Rheumatoid factor (RF) and anticyclic citrullinated peptides (anti-CCP) are biomarkers for the evaluation of RA although their functions in the pathogenesis of RA are poorly understood.
Meixing, Yu +3 more
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Follicular Helper CD4 T Cells (TFH)
Annual Review of Immunology, 2011T cell help to B cells is a fundamental aspect of adaptive immunity and the generation of immunological memory. Follicular helper CD4 T (TFH) cells are the specialized providers of B cell help. TFHcells depend on expression of the master regulator transcription factor Bcl6.
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Primary cutaneous follicular helper T‐cell lymphoma
Journal of Cutaneous Pathology, 2015Follicular helper T‐cells (TFH) represent a specific subset of CD4‐positive helper T‐cells that help B‐cells to differentiate into long‐lived antibody‐secreting plasma cells or memory B‐cells. The expression of TFH markers in neoplastic T‐cells, traditionally related to the angioimmunoblastic (AITL) subgroup of peripheral T‐cell lymphomas, is nowadays ...
Carlos, Santonja +5 more
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Priming T follicular helper cells
Science, 2017Dendritic Cells In our immune systems, T follicular helper (Tfh) cells modulate antibody production by B cells. Krishnaswamy et al. examined the ability of conventional dendritic cell (cDC) subsets to prime Tfh commitment in response to intranasal immunization in mice.
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Functional RNAs control T follicular helper cells
Journal of Human Genetics, 2016T follicular helper cells (Tfh cells), which are a prototypic subset of effector CD4+ T cells, regulate the production of high-affinity antibodies by controlling B cells at initial and recall phases. Since the discovery of Tfh cells in human tonsils, many notable studies focusing on Tfh cells have clarified mechanisms underlying Tfh-cell-related ...
Shingo, Ichimiya +4 more
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T follicular helper cells in human autoimmunity
Current Opinion in Immunology, 2016Studies with mouse models have established the pathogenic roles of T follicular helper (Tfh) cells in antibody-mediated autoimmune diseases. In contrast, evidence in human autoimmune pathogenesis has been lacking for years. Recent progress in understanding on the biology of human Tfh cells and on the approaches assessing their response has enabled ...
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T follicular helper cells in food allergy
Current Opinion in ImmunologyT follicular helper (Tfh) cells help direct the production of antibodies by B cells. In addition to promoting antibody responses to vaccination and infection, Tfh cells have been found to mediate antibody production to food antigens. Work over the past decade has delineated the specific phenotypes of Tfh cells that induce antibodies to food while also ...
Jennifer S, Chen +2 more
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Cytokine Expression by T Follicular Helper Cells
2017T follicular helper (Tfh) cells are a specialized subset of CD4+ T cells located within temporary structures known as germinal centers (GC) formed within B cell follicles of secondary lymphoid organs. In the GC, Tfh cells facilitate the production of high-affinity antibodies through secretion of effector cytokines, such as IL-21 and IL-4, and through ...
Christoph, Jandl +2 more
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Revisiting the follicular helper T cell paradigm
Nature Immunology, 2009Antibody responses are critical for host protection against many pathogens. By reporting what actually occurs in vivo, two new studies provide important clues about follicular helper T cells that are dedicated to providing help to B cells.
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