Results 181 to 190 of about 42,893 (255)

Risk of Bias Associated with Varying Sampling Strategies for External Comparator Cohorts for Single‐Arm Trials: Insights from Aggressive Lymphoma

Clinical Pharmacology &Therapeutics, EarlyView.
Marketing authorizations for oncology drugs are often based on single‐arm trials (SATs), and real‐world data‐based external comparator cohorts (ECCs) are increasingly explored to contextualize results. In retrospective studies, comparators may be identified by time of diagnosis but included based on time of relapse; such sampling strategies can ...
Mikkel Runason Simonsen, Shiva Leisner, Ahmed Ludvigsen Al‐Mashhadi, Laurids Østergaard Poulsen, Matthew Maurer, Lasse Hjort Jakobsen, Tarec Christoffer El‐Galaly   +6 more
wiley   +1 more source

PD-1 and ICOS are coexpressed in T follicular helper cells but define three stages of maturation of T follicular regulatory cells. [PDF]

Sci Adv
Ribeiro F, Antunes D, Pires AR, Rino J, Filipe B, Jesus K, Correia R, Fonseca VR, Kumar S, Graca L.   +9 more
europepmc   +1 more source

Impact of Operator Specialization and on‐Site Evaluation on Nondiagnostic Thyroid Fine‐Needle Aspiration: A Comparative Study

Diagnostic Cytopathology, EarlyView.
ABSTRACT Background Thyroid fine‐needle aspiration (FNA) is the primary diagnostic method for evaluating thyroid nodules; however, nondiagnostic results remain a significant limitation, often leading to repeat procedures and delayed diagnosis. Operator specialization and rapid on‐site evaluation (ROSE) have been proposed as strategies to improve ...
Fatlinda Sadiku, Marija Škerlj, Vesna Ramljak   +2 more
wiley   +1 more source

Interferon-mediated NK cell activation increases cytolytic activity against T follicular helper cells and limits antibody response to SARS-CoV-2. [PDF]

Nat Immunol
de Los Rios Kobara I, Jayewickreme R, Lee MJ, Wilk AJ, Stanford COVID-19 Biobank, Blomkalns AL, Nadeau KC, Yang S, Rogers AJ, Blish CA.   +9 more
europepmc   +1 more source

Oogenesis and germinal bed morphology of the brown anole (A. sagrei)

Developmental Dynamics, EarlyView.
Abstract Background The brown anole is a model species of the genus Anolis, a squamate (encompassing lizards and snakes) group widely studied in evolutionary, behavioral, and developmental biology. Full genome annotation, the establishment of gene editing techniques, and comprehensive description of reproductive tract morphology and embryogenesis in ...
Bonnie K. Kircher, Antonia Weberling, Erin J. Vance, Natalia A. Shylo, Katherine Starr, Zoe B. Griffin, Hannah Wilson, Melainia McClain, Florian Hollfelder, Suzannah A. Williams, Thomas J. Sanger, Richard R. Behringer, Paul A. Trainor   +12 more
wiley   +1 more source

Role of SoxE transcription factors in development and disease

Developmental Dynamics, EarlyView.
Abstract Sox8, Sox9, and Sox10 arose by multiple rounds of genome duplications from a single SoxE gene in ancestral vertebrates. In this review, we will briefly discuss the molecular structure and function of SoxE transcription factors and their evolutionary origin. We will then discuss their expression, function, and developmental disorders.
Merin Lawrence, Gerhard Schlosser
wiley   +1 more source

Mitochondrial One-Carbon Metabolism Drives CD34-Lineage Cells to Differentiate Into T Follicular Helper Cells to Form Tertiary Lymphoid Organs in Transplant Arteriosclerosis. [PDF]

Circulation
Sun X, Wu J, He T, Yao M, Qin L, Weng C, Peng L, Xiao Q, Lu Y, Yuan H, Xu Q, Cai J.   +11 more
europepmc   +1 more source

Jaw‐specific stem cell dynamics are associated with distinct enamel architecture in mouse incisors

Developmental Dynamics, EarlyView.
Abstract Background The continuously growing mouse incisor serves as a model for stem cell‐driven tooth renewal. Although mice possess maxillary and mandibular incisors, most studies have focused on the mandible. Potential differences in structure and renewal between these serially homologous organs remain insufficiently characterized.
Elias Shahin, Jihan Asmar, Sanako Takano, Jimmy K. Hu, Amnon Sharir   +4 more
wiley   +1 more source

Divergent phenotypic and functional roles of human T follicular helper cells from infancy to adulthood

Sureshchandra S, Kastenschmidt JM, Joloya EM, Wagoner ZW, Nair AK, Kim S, Zane N, Bhattacharya G, Monterroso AM, Cheng E, Sorn AM, Mitul MT, Beares H, Mendez G, Yates TB, Zhou F, Daugherty A, Thakur C, Brokstad KA, Trask D, Ahuja G, Zhong Q, Saligrama N, Cox RJ, Wagar LE.   +24 more
europepmc   +1 more source

Mechanism of biliary atresia caused by T follicular helper cells-induced immune injury. [PDF]

BMC Pediatr
Ji Z, Wu X, Ren H, Feng J.
europepmc   +1 more source