Results 181 to 190 of about 13,929,988 (284)

Germinal center formation is resilient to CD69 deletion on T follicular helper cells. [PDF]

Immunol Cell Biol
Guillaume SM, Carslaw HA, Innocentin S, Webb LMC, Liston A, Foster WS, Linterman MA.   +6 more
europepmc   +1 more source

Paediatric development of radiopharmaceutical imaging agents and radioligand therapeutics

British Journal of Clinical Pharmacology, EarlyView.
Abstract This review focuses on the development of radiopharmaceutical imaging agents and radioligand therapeutics for paediatric use. Nuclear medicine plays an important role in the diagnosis and treatment of various childhood conditions, including cancers, infections and brain disorders.
Justin L. Hay, Amandine Manon, Hunter Stephens, S. Y. Amy Cheung, Bart de Keizer, Erik T. te Beek   +5 more
wiley   +1 more source

Altered Cytokine-Induced STAT3 and STAT5 Activation of Peripheral T Follicular Helper Cells Contributes to Vaccine-Non-Responsiveness in Aging and HIV. [PDF]

Aging Cell
Davis S, Kupritz J, Singh P, Pahwa S, Pallikkuth S.   +4 more
europepmc   +1 more source

Clonal composition and persistence of antigen-specific circulating T follicular helper cells. [PDF]

Eur J Immunol, 2023
Hu M, Notarbartolo S, Foglierini M, Jovic S, Mele F, Jarrossay D, Lanzavecchia A, Cassotta A, Sallusto F.   +8 more
europepmc   +1 more source

Regulatory harmonization: Evolution, globalization and future directions

British Journal of Clinical Pharmacology, EarlyView.
Regulatory harmonization has become an increasingly important and accepted approach to streamline regulatory review processes and expedite access to safe, effective and high‐quality medicines globally. This review explores the evolution and current status of regulatory harmonization, convergence and reliance initiatives.
Orin Chisholm, Elaine Y. L. Blair, Christine Y. Lu   +2 more
wiley   +1 more source

T follicular helper cells in primary immune regulatory disorders. [PDF]

J Allergy Clin Immunol
Chamseddine S, Harris EM, Chou J.
europepmc   +1 more source

T Follicular Helper Cells in Tertiary Lymphoid Structure Contribute to Renal Fibrosis by IL-21. [PDF]

Int J Mol Sci, 2023
Luo R, Chang D, Zhang N, Cheng Y, Ge S, Xu G.   +5 more
europepmc   +1 more source

Model‐informed optimal dose selection of golcadomide in combination with R‐CHOP in patients with previously untreated aggressive B‐cell lymphoma

British Journal of Clinical Pharmacology, EarlyView.
Aims Golcadomide is a potential first‐in‐class oral CELMoD™ agent for the treatment of lymphoma. This study aims to develop model‐informed drug development (MIDD) approaches to support optimal dose selection of golcadomide in combination with immunotherapy rituximab, cyclophosphamide, doxorubicin, vincristine and prednisone (R‐CHOP) in alignment with ...
Xirong Zheng, Zhiling Yu, Mark Kaplan, Argyrios Gkasiamis, Akshay Sudhindra, Li Zhu, Manisha Lamba, Fan Wu   +7 more
wiley   +1 more source

Cholesterol promotes autoimmune pathology through T follicular helper cells. [PDF]

Cell Mol Immunol
Li W, Tsokos GC.
europepmc   +1 more source

Spatial dysregulation of T follicular helper cells impairs vaccine responses in aging. [PDF]

Nat Immunol, 2023
Silva-Cayetano A, Fra-Bido S, Robert PA, Innocentin S, Burton AR, Watson EM, Lee JL, Webb LMC, Foster WS, McKenzie RCJ, Bignon A, Vanderleyden I, Alterauge D, Lemos JP, Carr EJ, Hill DL, Cinti I, Balabanian K, Baumjohann D, Espeli M, Meyer-Hermann M, Denton AE, Linterman MA.   +22 more
europepmc   +1 more source