Possible role of human ribonuclease dicer in the regulation of R loops
FEBS Open Bio, EarlyView.R loops play an important role in regulating key cellular processes such as replication, transcription, centromere stabilization, or control of telomere length. However, the unscheduled accumulation of R loops can cause many diseases, including cancer, and neurodegenerative or inflammatory disorders. Interestingly, accumulating data indicate a possible
Klaudia Wojcik +2 more
wiley +1 more source
Destruction of CD4 T Lymphocytes Alone Cannot Account for their Long-term Decrease in AIDS [PDF]
arXiv, 2000 Following previous models describing a quasi steady state (QSS) for the evolution of HIV infection and AIDS, we have developed a larger formalism simulating the long-term evolution of the QSS We show that the long-term evolution of AIDS cannot be explained by the destruction alone of CD4 T cells, either directly or indirectly.
arxiv
Early Steps in Specific Tumor Cell Lysis by Sensitized Mouse T Lymphocytes [PDF]
, 1975 Eric Martz
openalex +1 more source
Pathogen-reactive T helper cell analysis in the pig [PDF]
, 2017 There is growing interest in studying host-pathogen interactions in human-relevant large animal models such as the pig. Despite the progress in developing immunological reagents for porcine T cell research, there is an urgent need to directly assess ...
Agnone +63 more
core +4 more sources
The role of circular RNAs in regulating cytokine signaling in cancer
FEBS Open Bio, EarlyView.Cytokines present in the tumor microenvironment fuel cancer development. Aberrant expression of circRNAs contributes to cancer progression. Cytokines are involved in regulating circRNA biogenesis. Furthermore, aberrantly expressed circRNAs regulate the expression of ligands, receptors, and downstream effectors involved in cytokine signaling to promote ...
Vandana Joshi +4 more
wiley +1 more source
The Suppression of Mitogen- and Alloantigen-Stimulated Peripheral Blood Lymphocytes by Cultured Human T Lymphocytes [PDF]
, 1979 Richard D. Maca +2 more
openalex +1 more source
Target cell-dependent T cell-mediated lysis of vaccinia virus-infected cells [PDF]
, 1975 Vaccinia virus specific cytotoxicity against infected target cells was observed in vitro. Spleen lymphocytes from normal and immunized mice of the inbred strains C3H and DBA/2 were incubated with vaccinia virus-infected and non-infected 51Cr-labeled ...
Alkan +36 more
core +1 more source
Development of 4T1 breast cancer mouse model system for preclinical carbonic anhydrase IX studies
FEBS Open Bio, EarlyView.Carbonic anhydrase IX (CAIX) is a well‐recognised therapeutic target and prognostic biomarker in cancer. We developed and characterised a robust murine breast cancer model system that is suitable for CAIX studies in vitro and in vivo—it comprises both CAIX‐positive and CAIX‐negative controls and provides a solid platform for the comprehensive ...
Zane Kalniņa +13 more
wiley +1 more source
Evidence for T Lymphocyte Subpopulations in the Rabbit [PDF]
, 1974 Michael W. Fanger +4 more
openalex +1 more source
Immunocto: a massive immune cell database auto-generated for histopathology [PDF]
arXivWith the advent of novel cancer treatment options such as immunotherapy, studying the tumour immune micro-environment (TIME) is crucial to inform on prognosis and understand potential response to therapeutic agents. A key approach to characterising the TIME may be through combining (1) digitised microscopic high-resolution optical images of hematoxylin
arxiv