Results 211 to 220 of about 12,046,757 (352)

Interactions of Antibody Drug Conjugate Anti‐Tubulin and Topoisomerase I Inhibitor Payloads with Radiotherapy to Potentiate Immunotherapy

Advanced Science, EarlyView.
Antibody drug conjugates deliver their cytotoxic anti‐tubulin or topoisomerase I inhibitor payloads to tumors through cancer cell receptor targeting. The released drug payloads induce cellular changes that interact with radiotherapy resulting in radiosensitization that improves cancer cell kill and stimulates anti‐tumor immune responses.
Jacqueline Lesperance, Bryan S. Yung, Michael M. Allevato, Marcus M Cheng, Maria F. Camargo, Robert Saddawi‐Konefka, Kanika Dhawan, Ashwyn K. Sharma, Mahsa Mortaja, Sophie Bice, Daniel J. Scanderbeg, Diego Alvarado, Jyoti Mayadev, Ramez N. Eskander, Stephen R. Adams, Pippa F. Cosper, J. Silvio Gutkind, Sunil J. Advani   +17 more
wiley   +1 more source

Actin conformation dynamics precede force generation in cytotoxic T lymphocytes

Lippert A, Rochussen A, Kebabci A, Winkel A, Franze K, Fletcher D, Griffiths G.   +6 more
europepmc   +2 more sources

Differentiated T Lymphocytes and Cancer Cell Mitochondrial Metabolism to Enhance Radioimmunotherapy by a Biomimetic Nanozyme System. [PDF]

Adv Sci (Weinh)
Zhang H, Deng Y, Lu Y, Wang M, Qiao K, Yang Z, Ning S, Liu T.   +7 more
europepmc   +1 more source

Tailoring Vascular‐Immune Homeostasis via Manganese‐DNA Complex‐Armed Immunogenic Extracellular Vesicles for Pancreatic Cancer Immunotherapy

Advanced Science, EarlyView.
This study demonstrates that Mn2⁺–tumor DNA complexes encapsulated in dendritic cell (DC)– derived immunogenic extracellular vesicles (EVDC@Mn‐DNA) act as a DC‐specific cGAS– STING activator. EVDC@Mn‐DNA treatment enhances intratumoral DC activation, improves tumor vascular function, promotes CD8⁺ T cell activity, and suppresses pancreatic tumor growth,
Xue Jiang, Lihuan Shang, Xiaochun Chen, Xiangzhan Kong, Xiaojuan Wang, Linjia Jiang, Huiying Zhao, Yafeng Zhu, Cheng Huang, Shiyi Deng, Rui Zhang, Minghui Wang, Haoming Lin, Ping‐Pui Wong   +13 more
wiley   +1 more source

mRNA-engineered T lymphocytes secreting bispecific T cell engagers with therapeutic potential in solid tumors. [PDF]

Front Immunol
Zagorac I, Ramírez-Fernández Á, Tapia-Galisteo A, Rubio-Pérez L, Gómez-Rosel M, Grau M, Rodríguez-Peralto JL, Álvarez-Vallina L, Blanco B.   +8 more
europepmc   +1 more source

Cytolytic T Lymphocyte Clones

Immunobiology, 1982
H R, MacDonald, R P, Sekaly, O, Kanagawa, N, Thiernesse, C, Taswell, J C, Cerottini, A, Weiss, A L, Glasebrook, H D, Engers, A, Kelso, K T, Brunner, C, Bron   +11 more
openaire   +2 more sources

Chronic exercise stress in mice depresses splenic T lymphocyte mitogenesis in vitro.

, 1986
Laurie Hoffman‐Goetz, R. Keir, R Thorne, M. E. Houston, Carolyn Young   +4 more
openalex   +1 more source

YKT6 Promotes Bladder Cancer Progression by Stabilizing β‐catenin Through USP7‐Mediated Deubiquitination

Advanced Science, EarlyView.
The SNARE protein YKT6 is upregulated in bladder cancer (BLCA), correlating with poor prognosis. YKT6 promotes tumor proliferation and metastasis by activating Wnt/β‐catenin signaling. It recruits Ubiquitin‐Specific Peptidase 7 (USP7) to deubiquitinate and stabilize β‐catenin, enhancing its nuclear accumulation and driving oncogenic gene expression ...
Sheng Tu, Wenzhi Du, Yongwen Luo, Jiageng Shi, Tianyun Liu, Meng Ji, Kangping Xiong, Siming Chen, Fenfang Zhou, Mingxing Li, Jingtian Yu, Gang Wang, Lingao Ju, Yi Zhang, Yu Xiao, Xinghuan Wang, Kaiyu Qian   +16 more
wiley   +1 more source

Correction to "Association Between CD20+ T Lymphocytes and Neuropsychological Findings in Multiple Sclerosis". [PDF]

Eur J Neurol
europepmc   +1 more source

Dormant Metastases Exhibit a Unique Phenotype Primarily Promoted by the Ch25h Gene and Are Maintained in Dormancy by T Lymphocytes. [PDF]

MedComm (2020)
Chamorro V, Algarra I, Sanz V, Pulido M, Romero I, Chico E, Millán M, Escaño-Maestre M, Botella P, Linares I, García-Lora ÁM.   +10 more
europepmc   +1 more source