Results 91 to 100 of about 6,764,527 (311)
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Pengaruh Modernisasi Sistem Administrasi Perpajakan terhadap Tingkat Kepatuhan Wajib Pajak pada Kantor Pelayanan Pajak Pratama Batu [PDF]
, 2014 This research is motivated because the tax administration system modernization efforts undertaken by the Directorate General of Taxation is the current omzet limit changes for the Taxable Enterprises inaugural from Rp 600.000.000,- to Rp 4,8 billion ...
Sofiyana, R. L. (Rindi)
core
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
An Economic Analysis of Modern Rice Production Technology and its Adoption Behaviour in Tamil Nadu [PDF]
Rice is the staple food in Tamil Nadu and is grown in an area of 2.6 Mha with a production of 8.19 Mt and productivity of 3.2 t/ha. In the context of high water demand by rice farmers, any strategy that would produce higher rice yield with less water is ...
Devi, K. Sita, Ponnarasi, T.
core +1 more source
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
The dynamic process of economic takeoff and industrial transformation [PDF]
This paper studies the patterns and key determinants of staged economic development. We construct a two-sector dynamic general equilibrium model populated with one-period lived non-overlapping generations, featuring endogenous enhancement in modern ...
Chang, Ming-Jen +2 more
core +1 more source
An Analysis of Information Technology Publications in Leading Hospitality Journals [PDF]
, 2005 In response to the recent wide-scale applications of lnformation Technology (I/T) in the hospitality industry, this study analyzed articles in leading hospitality research journals, including the International Journal of Hospitality Management, Cornell ...
Law, Rob, Leung, Rosanna
core
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
X-band Power Amplifier for future generation SAR T/R modules in HBT technology
, 2005 This paper deals with the design of X-band T/R modules to be employed on a future generation Synthetic Aperture Radar (SAR) for space application. Since the final High Power Amplifier (HPA) stage of the transmitting chain directly affects the overall module performances (mainly efficiency and maximum output power), HPA topic has been deeply ...
R. P. PAGANELLI +8 more
openaire +4 more sources
Project Based Learning Integrated to Stem to Enhance Elementary School's Students Scientific Literacy [PDF]
, 2016 This study was done to depict Project Based Learning (PjBL) integrated with science science, technology, engineering, and mathematics (STEM), to enhance elementary school students' science literation. Theme used in this study was air pollution.
Afriana, J. (J) +2 more
core +1 more source