Results 111 to 120 of about 28,279,407 (312)

Generation of a human iPSC line with heterozygous PRPF8 c.5792C > T, p. T1931M mutation to model retinitis pigmentosa using CRISPR/Cas9 technology

Stem Cell Research
Mutations in the PRPF8 gene frequently result in retinitis pigmentosa (RP), an autosomal dominant inherited retinal disease that can lead to nyctalopia and progressive vision loss. Currently, no effective treatment is available. In this study, we used CRISPR/Cas9 technology to introduce a heterozygous point mutation inthe PRPF8 gene of a normal induced
Hang Chen, Yuqin Liang, Yuexi Chen, Yuan Liang, Xiaoxue Li, Chunwen Duan, Zekai Cui, Jianing Gu, Chengcheng Ding, Xihao Sun, Jiansu Chen   +10 more
openaire   +3 more sources

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Interpretation of Sectoral Standard Requirements and Test Methods for Orthopaedic Surgical Navigation Equipment Employing Robotic Technology

Xiehe Yixue Zazhi
In recent years, robot-assisted technology has become increasingly sophisticated in the field of orthopedic surgical navigation. To ensure surgical safety and protect patient rights, corresponding products must undergo rigorous and standardized pre ...
TANG Qiaohong, MENG Xiangfeng, WANG Hao, LI Shu   +3 more
doaj   +1 more source

Strategy of smart meter infrastructure implementation using LPWAN technology, pilot project PLN Bali Case Study

MATEC Web of Conferences, 2018
To realize the Bali Eco Smart Grid program, state electricity company (PLN) Bali implemented the advanced metering infrastructure (AMI) through the deployment of a pilot project of 1,000 2 ways smart meters based on LoRa WAN in the Kuta area, Bali.
Wibisono Gunawan, Badruzzaman Nofiandri
doaj   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Contraloría General

, 2012
146 p.
Contraloría General, Contraloría General
core   +1 more source

Flipped classroom with gamified technology and paper-based method for teaching vocabulary

Asian-Pacific Journal of Second and Foreign Language Education
While gamified technology integration in vocabulary instruction within a flipped classroom has yielded beneficial teaching outcomes, specific studies have raised concerns about potential adverse effects linked to this approach.
Damar Isti Pratiwi, Sri Wuli Fitriati, Issy Yuliasri, Budi Waluyo   +3 more
doaj   +1 more source

Activation and Expansion of Human T-Cells Using Microfluidic Devices

Biosensors
Treatment of cancer patients with autologous T-cells expressing a chimeric antigen receptor (CAR) is one of the most promising therapeutic modalities for hematological malignancy treatment.
Ana Belén Peñaherrera-Pazmiño, Gustavo Rosero, Dario Ruarte, Julia Pinter, Karla Vizuete, Maximiliano Perez, Marie Follo, Betiana Lerner, Roland Mertelsmann   +8 more
doaj   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source