Results 121 to 130 of about 28,279,407 (312)
Molecular Oncology, EarlyView.We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth +17 more
wiley +1 more source
Molecular Oncology, EarlyView.Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu +9 more
wiley +1 more source
FEBS Open Bio, EarlyView.Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei +3 more
wiley +1 more source
Research on technical standards for intelligent fully-mechanized excavation in coal mines
Meikuang AnquanAiming at the bottlenecks of lagging safety standards and the lack of quantitative performance indicators in the large-scale application of intelligent fully-mechanized excavation technology (referred to as “fully-mechanized excavation”) in coal mines ...
Yan Song
doaj +1 more source
CD8⁺ T Cell Response to Influenza Virus
, 2005 Thesis: S.M., Massachusetts Institute of Technology, Department of Biology, 2005.Cataloged from PDF version of thesis.Includes bibliographical references (pages 10-12).The flu is an extremely prevalent and potentially devastating disease, especially ...
Doty, Daniel, S.M. Massachusetts Institute of Technology
core
Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies
FEBS Open Bio, EarlyView.We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli +8 more
wiley +1 more source
FEBS Open Bio, EarlyView.The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong +3 more
wiley +1 more source
Technology imports and the development of local capabilities
, 1982 Meeting: Caribbean Technology Policy Studies Project Phase II, Workshop, 31 May-6 June 1982, Port of Spain ...
Caribbean Technology Policy Studies Project +1 more
core +1 more source
Attenuation of Influenza a Virus into Live Vaccines Through C‐End Degrons
Advanced ScienceHarnessing the cell's ubiquitin‐proteasome system (UPS) to manipulate viral protein degradation represents a promising way to develop live attenuated vaccines.
Ping Wang +14 more
doaj +1 more source
FEBS Open Bio, EarlyView.In normal (nontolerant) cells, CD14 is crucial for both LPS uptake and LPS signaling. In LPS‐tolerant cells, in which LPS‐induced TNF‐α and IFN‐β production is suppressed, there is a dramatic increase in surface CD14 expression. The overexpressed CD14 in LPS‐tolerant cells is responsible for the enhanced LPS uptake without inducing pro‐inflammatory ...
Saeka Nishihara +3 more
wiley +1 more source