Results 121 to 130 of about 5,743,561 (311)

Influence of terahertz waves on the fiber direction of CFRP composite laminates [PDF]

, 2012
The importance of Carbon-fiber reinforced plastics (CFRP) are widely utilized due to more high performance in engineering structures. It was well known that a nondestructive technique would be very beneficial.
Barnard, Daniel J., Chiou, Chien-Ping T., Hsu, David K., Im, Kwang-Hee, Park, Je-Woong, Yang, In-young   +5 more
core   +2 more sources

Generation of a human iPSC line with heterozygous PRPF8 c.5792C > T, p. T1931M mutation to model retinitis pigmentosa using CRISPR/Cas9 technology

Stem Cell Research
Mutations in the PRPF8 gene frequently result in retinitis pigmentosa (RP), an autosomal dominant inherited retinal disease that can lead to nyctalopia and progressive vision loss. Currently, no effective treatment is available. In this study, we used CRISPR/Cas9 technology to introduce a heterozygous point mutation inthe PRPF8 gene of a normal induced
Hang Chen, Yuqin Liang, Yuexi Chen, Yuan Liang, Xiaoxue Li, Chunwen Duan, Zekai Cui, Jianing Gu, Chengcheng Ding, Xihao Sun, Jiansu Chen   +10 more
openaire   +3 more sources

Applicability of mitotic figure counting by deep learning: a development and pan‐cancer validation study

FEBS Open Bio, EarlyView.
In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes, Maria X. Isaksen, Frida Julbø, Manohar Pradhan, Andreas Kleppe, Sepp De Raedt, Ole‐Johan Skrede, Turid Torheim, John Arne Nesheim, Hans Martin Mohn, Hanne A. Askautrud, Karolina Cyll, Wanja Kildal, Emma Rewcastle, Melinda Lillesand, Vebjørn Kvikstad, Emiel Janssen, Robert Jones, Odd Terje Brustugun, Bjørn Brennhovd, Erik Skaaheim Haug, Lill‐Tove Rasmussen Busund, Elin Richardsen, Sigve Andersen, Tom Dønnem, Kristina Lindemann, Gunnar Kristensen, Neil A. Shepherd, Marco Novelli, Knut Liestøl, David Kerr, Håvard E. Danielsen, Tarjei S. Hveem   +32 more
wiley   +1 more source

Activation and Expansion of Human T-Cells Using Microfluidic Devices

Biosensors
Treatment of cancer patients with autologous T-cells expressing a chimeric antigen receptor (CAR) is one of the most promising therapeutic modalities for hematological malignancy treatment.
Ana Belén Peñaherrera-Pazmiño, Gustavo Rosero, Dario Ruarte, Julia Pinter, Karla Vizuete, Maximiliano Perez, Marie Follo, Betiana Lerner, Roland Mertelsmann   +8 more
doaj   +1 more source

The effects of scientific literacy on participation to political decision making

SHS Web of Conferences, 2016
The low levels of scientific literacy among the general public in a society where technology penetrates all aspects of everyday life creates major citizenship problems. One of the main goals of education is increasing the civic scientific literacy of the
Süerdem Ahmet, Çağlıyor Sandy
doaj   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Tests of gravity Using Lunar Laser Ranging [PDF]

Lunar laser ranging (LLR) has been a workhorse for testing general relativity over the pa~t four decades. The three retrorefiector arrays put on the Moon by the Apollo astronauts and the French built array on the second Soviet Lunokhod rover continue to ...
Merkowitz, Stephen M.
core   +1 more source

Technology strategies for low-carbon economic growth: a general equilibrium assessment [PDF]

, 2016
This paper investigates the potential for developing countries to mitigate greenhouse gas emissions without slowing their expected economic growth. A theoretical frame- work is developed that unifies bottom-up marginal abatement cost curves and partial ...
Sue Wing, Ian, Timilsina, Govinda R.
core  

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Nonprofit Capacity Assessment: Indiana Charities, 2007 [PDF]

, 2007
Presents findings from a survey of Indiana nonprofit organizations about their needs for technical assistance and capacity building.
Helen Liu, Kirsten A. Grønbjerg, Laney Cheney, Scott Leadingham   +3 more
core