Public Transcriptomic Data Meta-Analysis Demonstrates TAAR6 Expression in the Mental Disorder-Related Brain Areas in Human and Mouse Brain [PDF]
Biomolecules, 2022 G protein-coupled trace amine-associated receptors (TAAR) recognize different classes of amine compounds, including trace amines or other exogenous and endogenous molecules.
Ramilya Z Murtazina +2 more
exaly +8 more sources
Deregulation of Trace Amine-Associated Receptors (TAAR) Expression and Signaling Mode in Melanoma [PDF]
Biomolecules, 2022 Trace amine-associated receptors (TAARs) interact with amine compounds called “trace amines” which are present in tissues at low concentrations. Recently, TAARs expression in neoplastic tumors was reported. In this study, TAARs expression was analyzed in
Anastasia Vaganova +2 more
exaly +6 more sources
Expression of Trace Amine-Associated Receptors in the Murine and Human Hippocampus Based on Public Transcriptomic Data [PDF]
Cells, 2022 Hippocampus is one of the neurogenic zones where adult neurogenesis takes place. This process is quite complex and has a multicomponent regulation. A family of G protein-coupled trace amine-associated receptors (TAARs) was discovered only in 2001, and ...
Anastasia Vaganova +2 more
exaly +6 more sources
Pharmacoinformatics and molecular docking reveal potential drug candidates against Schizophrenia to target TAAR6 [PDF]
Journal of Cellular Physiology, 2019 Schizophrenia (SZ) is a complex disabling disorder that leads to the mental disability and afflicts 1% of the world's total population and placed in top ten medical disorders.
Hao Wu +2 more
exaly +6 more sources
Search for Structural Basis of Interactions of Biogenic Amines with Human TAAR1 and TAAR6 Receptors. [PDF]
Int J Mol Sci, 2021 The identification and characterization of ligand-receptor binding sites are important for drug development. Trace amine-associated receptors (TAARs, members of the class A GPCR family) can interact with different biogenic amines and their metabolites ...
Glyakina AV +5 more
europepmc +6 more sources
Identifying human diamine sensors for death related putrescine and cadaverine molecules [PDF]
PLoS Computational Biology, 2018 Pungent chemical compounds originating from decaying tissue are strong drivers of animal behavior. Two of the best-characterized death smell components are putrescine (PUT) and cadaverine (CAD), foul-smelling molecules produced by decarboxylation of ...
Angel Gonzalez +2 more
exaly +7 more sources
Trace Amine-Associated Receptors and Monoamine-Mediated Regulation of Insulin Secretion in Pancreatic Islets [PDF]
Biomolecules, 2023 Currently, metabolic syndrome treatment includes predominantly pharmacological symptom relief and complex lifestyle changes. Trace amines and their receptor systems modulate signaling pathways of dopamine, norepinephrine, and serotonin, which are ...
Anastasia N. Vaganova +5 more
doaj +4 more sources
The Expression of Trace Amine-Associated Receptors (TAARs) in Breast Cancer Is Coincident with the Expression of Neuroactive Ligand–Receptor Systems and Depends on Tumor Intrinsic Subtype [PDF]
Biomolecules, 2023 Currently, the contribution of trace amine-associated receptors (TAARs) to breast cancer (BC) is recognized, but their associations with various pathological characteristics are not yet understood.
Anastasia N. Vaganova +4 more
doaj +4 more sources
Trace Amine-Associated Receptors’ Role in Immune System Functions [PDF]
BiomedicinesTrace amines are a separate, independent group of biogenic amines, close in structure to classical monoamine neurotransmitters such as dopamine, serotonin, and norepinephrine that include many products of the endogenous or bacteria-mediated ...
Vyacheslav I. Moiseenko +3 more
doaj +4 more sources
TAARs as Novel Therapeutic Targets for the Treatment of Depression: A Narrative Review of the Interconnection with Monoamines and Adult Neurogenesis [PDF]
BiomedicinesDepression is a common mental illness of great concern. Current therapy for depression is only suitable for 80% of patients and is often associated with unwanted side effects.
Taisiia S. Shemiakova +2 more
doaj +4 more sources