Trace Amine-Associated Receptors’ Role in Immune System Functions [PDF]
BiomedicinesTrace amines are a separate, independent group of biogenic amines, close in structure to classical monoamine neurotransmitters such as dopamine, serotonin, and norepinephrine that include many products of the endogenous or bacteria-mediated ...
Vyacheslav I. Moiseenko +3 more
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Trace Amine-Associated Receptors and Monoamine-Mediated Regulation of Insulin Secretion in Pancreatic Islets [PDF]
Biomolecules, 2023 Currently, metabolic syndrome treatment includes predominantly pharmacological symptom relief and complex lifestyle changes. Trace amines and their receptor systems modulate signaling pathways of dopamine, norepinephrine, and serotonin, which are ...
Anastasia N. Vaganova +5 more
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Natural variability of trace-amine associated receptors in wild meerkats [PDF]
Frontiers in ZoologyBackground The study of olfaction as a sensory modality has been relatively neglected in comparison to other sensory cues, particularly in wildlife research.
Johannes Fähnle +6 more
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Molecular Evolution and Functional Divergence of Trace Amine-Associated Receptors. [PDF]
PLoS ONE, 2016 Trace amine-associated receptors (TAARs) are a member of the G-protein-coupled receptor superfamily and are known to be expressed in olfactory sensory neurons. A limited number of molecular evolutionary studies have been done for TAARs so far.
Seong-Il Eyun +3 more
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The Expression of Trace Amine-Associated Receptors (TAARs) in Breast Cancer Is Coincident with the Expression of Neuroactive Ligand–Receptor Systems and Depends on Tumor Intrinsic Subtype [PDF]
Biomolecules, 2023 Currently, the contribution of trace amine-associated receptors (TAARs) to breast cancer (BC) is recognized, but their associations with various pathological characteristics are not yet understood.
Anastasia N. Vaganova +4 more
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Expression of Trace Amine-Associated Receptors in the Murine and Human Hippocampus Based on Public Transcriptomic Data [PDF]
Cells, 2022 Hippocampus is one of the neurogenic zones where adult neurogenesis takes place. This process is quite complex and has a multicomponent regulation. A family of G protein-coupled trace amine-associated receptors (TAARs) was discovered only in 2001, and ...
Nataliia V. Katolikova +3 more
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Deregulation of Trace Amine-Associated Receptors (TAAR) Expression and Signaling Mode in Melanoma [PDF]
Biomolecules, 2022 Trace amine-associated receptors (TAARs) interact with amine compounds called “trace amines” which are present in tissues at low concentrations. Recently, TAARs expression in neoplastic tumors was reported. In this study, TAARs expression was analyzed in
Anastasia N. Vaganova +3 more
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Coordination of two enhancers drives expression of olfactory trace amine-associated receptors [PDF]
Nature Communications, 2021 In our nose, some neuron subpopulations express a family of trace amine associated receptors (TAARs, smelling e.g., rotten fish). Fei et al. identify two conserved enhancers across placental mammals named TAAR enhancer 1 and 2 that coordinately regulate ...
Aimei Fei +19 more
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Olfactory expression of trace amine-associated receptors requires cooperative cis-acting enhancers [PDF]
Nature Communications, 2021 How olfactory sensory neurons express one allele of one TAAR gene is not well understood. Here the authors identify two cooperative cis-acting enhancers that govern TAAR gene choice and that share both similarities and differences with known olfactory ...
Ami Shah +4 more
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Trace Amine-Associated Receptors as Novel Therapeutic Targets for Immunomodulatory Disorders [PDF]
Frontiers in Pharmacology, 2018 Trace amines and their receptors (trace amine-associated receptors; TAARs) are an emerging pharmacological target for the treatment of human disorders.
Sherri L. Christian, Mark D. Berry
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