Trace amine-associated receptors and their ligands. [PDF]
Br J Pharmacol, 2006 Classical biogenic amines (adrenaline, noradrenaline, dopamine, serotonin and histamine) interact with specific families of G protein‐coupled receptors (GPCRs). The term ‘trace amines’ is used when referring top‐tyramine, β‐phenylethylamine, tryptamine and octopamine, compounds that are present in mammalian tissues at very low (nanomolar ...
Zucchi R +3 more
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Trace amine-associated receptors as potential targets for the treatment of anxiety and depression [PDF]
Frontiers in PharmacologyIn the metabolic pathways associated with major biogenic amines, such as dopamine, noradrenaline, and serotonin, there exists a group of compounds known as trace amines.
Zelong Li +5 more
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Functional evolution of the trace amine associated receptors in mammals and the loss of TAAR1 in dogs [PDF]
BMC Evolutionary Biology, 2010 Background The trace amine associated receptor family is a diverse array of GPCRs that arose before the first vertebrates walked on land. Trace amine associated receptor 1 (TAAR1) is a wide spectrum aminergic receptor that acts as a modulator in brain ...
Westmoreland Susan V +3 more
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Trace amine-associated receptors (TAARs)2-9 knockout mice exhibit reduced wakefulness and disrupted REM sleep [PDF]
Frontiers in PsychiatryIntroductionThis study aimed to investigate the role of TAAR2-9 in sleep/wake regulation, given TAAR1's known involvement in modulating neurotransmitter release and sleep patterns.MethodsMale TAAR2-9 knockout (KO) and wild-type (WT) mice were compared ...
Sunmee Park +8 more
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Biomedicines, 2023 All antipsychotics currently used in clinic block D2 dopamine receptors. Trace amine-associated receptor 1 is emerging as a new therapeutic target for schizophrenia and several other neuropsychiatric disorders.
Savelii R. Kuvarzin +4 more
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Structural and functional evolution of the trace amine-associated receptors TAAR3, TAAR4 and TAAR5 in primates. [PDF]
PLoS ONE, 2010 The family of trace amine-associated receptors (TAAR) comprises 9 mammalian TAAR subtypes, with intact gene and pseudogene numbers differing considerably even between closely related species.
Claudia Stäubert +5 more
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Amine-responsive Rhodopsin-like GPCRs in ocular pathology: mechanistic associations, candidate biomarkers, and therapeutic potential [PDF]
Frontiers in PhysiologyRhodopsin-like G protein-coupled receptors (GPCRs) play a pivotal role in ophthalmic pathologies, and recent studies have substantially advanced our understanding of their underlying molecular mechanisms. Amine-responsive Rhodopsin-like GPCRs (ARh-GPCRs),
Han Yu +4 more
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Genome-wide identification, expression analysis of taars (trace amine-associated receptors) and response to cadaverine and putrescine in Mandarin fish (Siniperca chuatsi) [PDF]
BMC GenomicsBackground The unique feeding behavior of Siniperca chuatsi (S. chuatsi), which exclusively consumes live fry and rejects dead fry, severely limits the development of its aquaculture industry.
Xiaoru Dong +4 more
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Olfactory signaling via trace amine-associated receptors. [PDF]
Cell Tissue Res, 2021 Trace amine-associated receptors (TAARs) are a family of G protein-coupled receptors that function as odorant receptors in the main olfactory system of vertebrates. TAARs are monoallelically expressed in primary sensory neurons where they couple to the same transduction cascade as canonical olfactory receptors and are mapped onto glomeruli within a ...
Dewan A.
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Evolution of Brain-Expressed Biogenic Amine Receptors into Olfactory Trace Amine-Associated Receptors. [PDF]
Mol Biol Evol, 2022 Guo L +9 more
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