Results 1 to 10 of about 346 (89)

Knocking Out TAAR5: A Pathway to Enhanced Neurogenesis and Dopamine Signaling in the Striatum [PDF]

Cells
The member of trace-amine associated receptor family, TAAR5 receptor was suggested to recognize tertiary amines, mostly in the olfactory system; however, knocking out the receptor TAAR5 in mice showed an enhancing effect on adult neurogenesis and ...
Anastasia Vaganova, Zoia S Fesenko, Nataliia Katolikova   +2 more
exaly   +4 more sources

Exploring Consequences of Predator Stress on Behaviors of Mice Lacking Trace Amine-Associated Receptor 5 (TAAR5) [PDF]

Cells
Recent studies indicated a connection between trace amine-associated receptor 5 (TAAR5) and emotional behaviors related to anxiety and depression; however, the neurobiological basis of this link is still unclear.
Vsevolod V Nemets, Evgeny Budygin, Raul Gainetdinov   +2 more
exaly   +4 more sources

Role of the trace amine associated receptor 5 (TAAR5) in the sensorimotor functions [PDF]

Scientific Reports, 2021
Classical monoamines are well-known modulators of sensorimotor neural networks. However, the role of trace amines and their receptors in sensorimotor function remains unexplored.
Anastasia Vaganova, Pavel Musienko, Savelii R Kuvarzin   +2 more
exaly   +3 more sources

Improved cognitive performance in trace amine-associated receptor 5 (TAAR5) knock-out mice [PDF]

Scientific Reports, 2022
Trace amine-associated receptors (TAARs) are a family of G protein-coupled receptors present in mammals in the brain and several peripheral organs. Apart from its olfactory role, TAAR5 is expressed in the major limbic brain areas and regulates brain ...
Silvia Maggi, Stefano Gustincich, Stefano Espinoza   +2 more
exaly   +3 more sources

TAAR5 Modulates Sensorimotor Recovery After Spinal Cord Injury [PDF]

Biomedicines
Background: Spinal cord injury (SCI) is a severe pathological condition resulting in persistent motor and sensory impairments. The trace amine-associated receptor 5 (TAAR5) is a potential modulator of central nervous system functions; however, its role ...
Anastasiia D. Buglinina, Ekaterina A. Romanyuk, Alexander A. Chesnokov, Sviatoslav I. Milov, Polina Yu. Shkorbatova, Natalia V. Pavlova, Nataliia V. Katolikova, Raul R. Gainetdinov, Daria S. Kalinina, Pavel E. Musienko   +9 more
doaj   +2 more sources

Transcriptomic Analysis of Taar5 Expression and Co-Expression Networks in the Cerebellum During Perinatal Development [PDF]

Brain Sciences
Background: Dopamine participates in the cognitive cerebellar role and in cerebellum development. The trace amine-associated receptor (TAARs, TAAR1-TAAR9) system contributes to dopamine signaling tuning.
Anastasia N. Vaganova, Ramilya Z. Murtazina, Anna B. Volnova, Vassiliy Tsytsarev, Alena B. Karaseva, Evgeniya V. Efimova, Raul R. Gainetdinov   +6 more
doaj   +2 more sources

Gut microbe-derived trimethylamine shapes circadian rhythms through the host receptor TAAR5 [PDF]

eLife
Elevated levels of the gut microbe-derived metabolite trimethylamine N-oxide (TMAO) are associated with cardiometabolic disease risk. However, the mechanism(s) linking TMAO production to human disease are incompletely understood.
Kala K Mahen, William J Massey, Danny Orabi, Amanda L Brown, Thomas C Jaramillo, Amy Burrows, Anthony J Horak, Sumita Dutta, Marko Mrdjen, Nour Mouannes, Venkateshwari Varadharajan, Lucas J Osborn, Xiayan Ye, Dante M Yarbrough, Treg Grubb, Natalie Zajczenko, Rachel Hohe, Rakhee Banerjee, Pranavi Linga, Dev Laungani, Adeline M Hajjar, Naseer Sangwan, Mohammed Dwidar, Jennifer A Buffa, Garth R Swanson, Zeneng Wang, Jonathan Mark Brown   +26 more
doaj   +2 more sources

Expression of Trace Amine-Associated Receptors in the Murine and Human Hippocampus Based on Public Transcriptomic Data [PDF]

Cells, 2022
Hippocampus is one of the neurogenic zones where adult neurogenesis takes place. This process is quite complex and has a multicomponent regulation. A family of G protein-coupled trace amine-associated receptors (TAARs) was discovered only in 2001, and ...
Nataliia V. Katolikova, Anastasia N. Vaganova, Evgeniya V. Efimova, Raul R. Gainetdinov   +3 more
doaj   +2 more sources

The Expression of Trace Amine-Associated Receptors (TAARs) in Breast Cancer Is Coincident with the Expression of Neuroactive Ligand–Receptor Systems and Depends on Tumor Intrinsic Subtype [PDF]

Biomolecules, 2023
Currently, the contribution of trace amine-associated receptors (TAARs) to breast cancer (BC) is recognized, but their associations with various pathological characteristics are not yet understood.
Anastasia N. Vaganova, Daria D. Maslennikova, Valeria V. Konstantinova, Evgeny V. Kanov, Raul R. Gainetdinov   +4 more
doaj   +2 more sources

Trace Amine-Associated Receptors and Monoamine-Mediated Regulation of Insulin Secretion in Pancreatic Islets [PDF]

Biomolecules, 2023
Currently, metabolic syndrome treatment includes predominantly pharmacological symptom relief and complex lifestyle changes. Trace amines and their receptor systems modulate signaling pathways of dopamine, norepinephrine, and serotonin, which are ...
Anastasia N. Vaganova, Taisiia S. Shemyakova, Karina V. Lenskaia, Roman N. Rodionov, Charlotte Steenblock, Raul R. Gainetdinov   +5 more
doaj   +2 more sources