Results 31 to 40 of about 346 (89)
Disease Markers, Volume 2022, Issue 1, 2022., 2022 The gut bacterial community is involved in the metabolism of bile acids and short‐chain fatty acids (SCFAs). Bile acids are involved in the absorption of fat and the regulation of lipid homeostasis through emulsification and are transformed into unconjugated bile acids by the gut microbiota.
Indranil Chattopadhyay +7 more
wiley +1 more source
THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: G protein‐coupled receptors
British Journal of Pharmacology, Volume 178, Issue S1, Page S27-S156, October 2021., 2021 The Concise Guide to PHARMACOLOGY 2021/22 is the fifth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of nearly 1900 human drug targets with an emphasis on selective pharmacology (where available), plus links to the open access knowledgebase source of drug targets ...
Stephen P H Alexander +154 more
wiley +1 more source
An evolutionary conserved olfactory receptor for foodborne and semiochemical alkylpyrazines
The FASEB Journal, Volume 35, Issue 6, June 2021., 2021 Abstract Molecular recognition is a fundamental principle in biological systems. The olfactory detection of both food and predators via ecological relevant odorant cues are abilities of eminent evolutionary significance for many species. Pyrazines are such volatile cues, some of which act as both human‐centered key food odorants (KFOs) and ...
Patrick Marcinek +3 more
wiley +1 more source
Aging Cell, Volume 20, Issue 5, May 2021., 2021 TMA alters development, aging and neurodegeneration in C. elegans. Observed results suggests that the bacterial metabolite TMA alters development, aging and neurodegeneration in C. elegans through DAF‐11 and DAF‐16 pathways. Abstract In the nematode Caenorhabditis elegans, signals derived from bacteria in the diet, the animal's major nutrient source ...
Amit Khanna +12 more
wiley +1 more source
Inverse agonistic action of 3-iodothyronamine at the human trace amine-associated receptor 5.
PLoS ONE, 2015 ObjectiveApplication of 3-iodothyronamine (3-T1AM) results in decreased body temperature and body weight in rodents. The trace amine-associated receptor (TAAR) 1, a family A G protein-coupled receptor, is a target of 3-T1AM. However, 3-T1AM effects still
Juliane Dinter +12 more
doaj +1 more source
Molecular Evolution and Functional Divergence of Trace Amine-Associated Receptors. [PDF]
PLoS ONE, 2016 Trace amine-associated receptors (TAARs) are a member of the G-protein-coupled receptor superfamily and are known to be expressed in olfactory sensory neurons. A limited number of molecular evolutionary studies have been done for TAARs so far.
Seong-Il Eyun +3 more
doaj +1 more source
Interkingdom Interactions in the Gut: Ecological Mechanisms, Homeostasis, and Therapeutic Modulation
Gut Medicine, Volume 2, Issue 1, Page 23-39, March 2026.ABSTRACT The gut microbiota constitutes a highly complex and dynamic ecosystem that profoundly influences host physiology, metabolism, and immunity. This review provides an integrative overview of the mechanisms through which gut microorganisms—particularly bacteria and fungi—interact with host cells and with each other to maintain intestinal ...
Rui‐Qi Wei +5 more
wiley +1 more source
Sensory Neuroscience, Volume 2, Issue 1, March 2026.This schematic highlights GPCRs as the central hub of olfactory signaling in health and disease. The central GPCR shows odorant activation and downstream pathways. Surrounding quadrants illustrate four GPCR‐mediated themes: odor perception and adaptation, mucosal immunity and regeneration, memory consolidation via neural circuits, and GPCR‐related ...
Zishuo Guo +11 more
wiley +1 more source
The Intersection of m6A Methylation and Immune Response in PCOS: A Bioinformatics Perspective
Immunity, Inflammation and Disease, Volume 14, Issue 2, February 2026.N6‐methyladenosine RNA methylation regulators are intricately linked with the development of polycystic ovary syndrome (PCOS) and may influence immune cell infiltration in affected individuals. This study enhances our understanding of the molecular interactions in PCOS and suggests potential biomarkers for diagnosis and targets for therapeutic ...
Wenting Xu +8 more
wiley +1 more source
The Concise Guide to PHARMACOLOGY 2025/26: Introduction and Other Protein Targets
British Journal of Pharmacology, Volume 182, Issue S1, Page S1-S23, December 2025.The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander +51 more
wiley +1 more source