Results 11 to 20 of about 346 (89)

Trace amine-associated receptors as potential targets for the treatment of anxiety and depression [PDF]

Frontiers in Pharmacology
In the metabolic pathways associated with major biogenic amines, such as dopamine, noradrenaline, and serotonin, there exists a group of compounds known as trace amines.
Zelong Li, Luoting Wan, Jing Dong, Jinquan Li, Jianfeng Liu, Jianfeng Liu   +5 more
doaj   +2 more sources

Deregulation of Trace Amine-Associated Receptors (TAAR) Expression and Signaling Mode in Melanoma [PDF]

Biomolecules, 2022
Trace amine-associated receptors (TAARs) interact with amine compounds called “trace amines” which are present in tissues at low concentrations. Recently, TAARs expression in neoplastic tumors was reported. In this study, TAARs expression was analyzed in
Anastasia N. Vaganova, Savelii R. Kuvarzin, Anastasia M. Sycheva, Raul R. Gainetdinov   +3 more
doaj   +2 more sources

Trace Amine-Associated Receptor 2 Is Expressed in the Limbic Brain Areas and Is Involved in Dopamine Regulation and Adult Neurogenesis [PDF]

Frontiers in Behavioral Neuroscience, 2022
Trace amines are a group of biogenic amines that are structurally and functionally close to classical monoamine neurotransmitters. Trace amine-associated receptors (TAARs) are emerging as promising targets for treating neuropsychiatric disorders.
Evgeniya V. Efimova, Saveliy R. Kuvarzin, Mikael S. Mor, Nataliia V. Katolikova, Taisiia S. Shemiakova, Valeria Razenkova, Maria Ptukha, Alena A. Kozlova, Ramilya Z. Murtazina, Daria Smirnova, Aleksandr A. Veshchitskii, Natalia S. Merkulyeva, Anna B. Volnova, Pavel E. Musienko, Pavel E. Musienko, Dmitrii E. Korzhevskii, Evgeny A. Budygin, Raul R. Gainetdinov, Raul R. Gainetdinov   +18 more
doaj   +2 more sources

TAARs as Novel Therapeutic Targets for the Treatment of Depression: A Narrative Review of the Interconnection with Monoamines and Adult Neurogenesis [PDF]

Biomedicines
Depression is a common mental illness of great concern. Current therapy for depression is only suitable for 80% of patients and is often associated with unwanted side effects.
Taisiia S. Shemiakova, Evgeniya V. Efimova, Raul R. Gainetdinov   +2 more
doaj   +2 more sources

TAAR8 in the Brain: Implications for Dopaminergic Function, Neurogenesis, and Behavior [PDF]

Biomedicines
Background/Objectives: G protein-coupled trace amine-associated receptors (TAARs) belong to a family of biogenic amine-sensing receptors. TAAR1 is the best-investigated receptor of this family, and TAAR1 agonists are already being tested in clinical ...
Taisiia S. Shemiakova, Alisa A. Markina, Evgeniya V. Efimova, Ramilya Z. Murtazina, Anna B. Volnova, Aleksandr A. Veshchitskii, Elena I. Leonova, Raul R. Gainetdinov   +7 more
doaj   +2 more sources

Trace Amine-Associated Receptors’ Role in Immune System Functions [PDF]

Biomedicines
Trace amines are a separate, independent group of biogenic amines, close in structure to classical monoamine neurotransmitters such as dopamine, serotonin, and norepinephrine that include many products of the endogenous or bacteria-mediated ...
Vyacheslav I. Moiseenko, Vera A. Apryatina, Raul R. Gainetdinov, Sergey A. Apryatin   +3 more
doaj   +2 more sources

TAAR9 knockout increases hippocampal serotonin and alters grooming behavior in rats [PDF]

Frontiers in Pharmacology
IntroductionDespite their association with brain disorders, the neurophysiological roles of the trace amine-associated receptors remain poorly understood.
Ilya S. Zhukov, Ilya S. Zhukov, Inessa V. Karpova, Ramilya Z. Murtazina, Yazen Alnefeesi, Olga M. Korenkova, Ilia Yu. Tissen, Svetlana A. Palchikova, Lydia A. Tokareva, Sarng S. Pyurveev, Petr D. Shabanov, Larisa G. Kubarskaya, Larisa G. Kubarskaya, Mikhail A. Rozhko, Ekaterina B. Zernova, Ekaterina A. Zolotoverkhaja, Anna B. Volnova, Allan V. Kalueff, Natalia V. Alenina, Raul R. Gainetdinov, Raul R. Gainetdinov   +20 more
doaj   +2 more sources

HISTOLOGICAL MAPPING OF TAAR5 EXPRESSION IN THE CENTRAL NERVOUS SYSTEM

IBRO Neuroscience Reports, 2023
Taisiia Shemiakova, Valeria Razenkova, Aleksandr Veshchitskii, Natalia Merkulyeva, Raul Gainetdinov   +4 more
exaly   +3 more sources

Pattern of TAAR5 Expression in the Human Brain Based on Transcriptome Datasets Analysis [PDF]

International Journal of Molecular Sciences, 2021
Ramilya Z Murtazina, Taisiia Shemiakova, Anastasia Vaganova   +2 more
exaly   +2 more sources

Minor Changes in Erythrocyte Osmotic Fragility in Trace Amine-Associated Receptor 5 (TAAR5) Knockout Mice [PDF]

International Journal of Molecular Sciences, 2021
Ilya Zhukov, Inessa V Karpova, Anastasia Vaganova   +2 more
exaly   +2 more sources