Results 21 to 30 of about 346 (89)

Discovery of Novel Trace Amine-Associated Receptor 5 (TAAR5) Antagonists Using a Deep Convolutional Neural Network [PDF]

International Journal of Molecular Sciences, 2022
Elena Cichero, Stefano Gustincich, Stefano Espinoza   +2 more
exaly   +2 more sources

Computational Methods for the Discovery and Optimization of TAAR1 and TAAR5 Ligands [PDF]

International Journal of Molecular Sciences
Elena Cichero, Chiara Brullo, Stefano Espinoza   +2 more
exaly   +2 more sources

Действие агониста TAAR1 RO 5263397 на дискинезию, вызываемую инъекцией α-NETA

Интегративная физиология, 2023
В настоящее время собрано достаточно данных о роли следовых аминов (СА) как нейромодуляторов в центральной нервной системе млекопитающих. СА имеют структурное сходство с классическими биогенными аминами, а изменения их концентрации связаны с различными ...
Надежда Владимировна Полякова, Антон Юрьевич Александров, Вероника Михайловна Князева, Екатерина Павловна Виноградова, Елена Сергеевна Дмитриева, Людмила Николаевна Станкевич, Александр Алексеевич Александров   +6 more
doaj   +1 more source

Trace Amine-Associated Receptor 5 Provides Olfactory Input Into Limbic Brain Areas and Modulates Emotional Behaviors and Serotonin Transmission

Frontiers in Molecular Neuroscience, 2020
Trace amine-associated receptors (TAARs) are a class of G-protein-coupled receptors found in mammals. While TAAR1 is expressed in several brain regions, all the other TAARs have been described mainly in the olfactory epithelium and the glomerular layer ...
Stefano Espinoza, Ilya Sukhanov, Evgeniya V. Efimova, Alena Kozlova, Kristina A. Antonova, Placido Illiano, Damiana Leo, Natalia Merkulyeva, Natalia Merkulyeva, Daria Kalinina, Daria Kalinina, Pavel Musienko, Pavel Musienko, Anna Rocchi, Anna Rocchi, Liudmila Mus, Liudmila Mus, Tatiana D. Sotnikova, Raul R. Gainetdinov, Raul R. Gainetdinov   +19 more
doaj   +1 more source

Human trace amine-associated receptor TAAR5 can be activated by trimethylamine. [PDF]

PLoS ONE, 2013
In addition to the canonical olfactory receptors, TAARs were currently suggested to be a second class of chemosensory receptors in the olfactory epithelium of vertebrates.
Ivonne Wallrabenstein, Jonas Kuklan, Lea Weber, Sandra Zborala, Markus Werner, Janine Altmüller, Christian Becker, Anna Schmidt, Hanns Hatt, Thomas Hummel, Günter Gisselmann   +10 more
doaj   +1 more source

The Concise Guide to PHARMACOLOGY 2023/24: G protein-coupled receptors

British Journal of Pharmacology, Volume 180, Issue S2, Page S23-S144, October 2023., 2023
The Concise Guide to PHARMACOLOGY 2023/24 is the sixth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of approximately 1800 drug targets, and about 6000 interactions with about 3900 ligands.
Stephen P. H. Alexander, Arthur Christopoulos, Anthony P. Davenport, Eamonn Kelly, Alistair A. Mathie, John A. Peters, Emma L. Veale, Jane F. Armstrong, Elena Faccenda, Simon D. Harding, Jamie A. Davies, Maria Pia Abbracchio, George Abraham, Alexander Agoulnik, Wayne Alexander, Khaled Al‐hosaini, Magnus Bäck, Jillian G. Baker, Nicholas M. Barnes, Ross Bathgate, Jean‐Martin Beaulieu, Annette G. Beck‐Sickinger, Maik Behrens, Kenneth E. Bernstein, Bernhard Bettler, Nigel J. M. Birdsall, Victoria Blaho, Francois Boulay, Corinne Bousquet, Hans Bräuner‐Osborne, Geoffrey Burnstock, Girolamo Caló, Justo P. Castaño, Kevin J. Catt, Stefania Ceruti, Paul Chazot, Nan Chiang, Bice Chini, Jerold Chun, Antonia Cianciulli, Olivier Civelli, Lucie H. Clapp, Réjean Couture, Helen M. Cox, Zsolt Csaba, Claes Dahlgren, Gordon Dent, Steven D. Douglas, Pascal Dournaud, Satoru Eguchi, Emanuel Escher, Edward J. Filardo, Tung Fong, Marta Fumagalli, Raul R. Gainetdinov, Michael L. Garelja, Marc de Gasparo, Craig Gerard, Marvin Gershengorn, Fernand Gobeil, Theodore L. Goodfriend, Cyril Goudet, Lukas Grätz, Karen J. Gregory, Andrew L. Gundlach, Jörg Hamann, Julien Hanson, Richard L. Hauger, Debbie L. Hay, Akos Heinemann, Deron Herr, Morley D. Hollenberg, Nicholas D. Holliday, Mastgugu Horiuchi, Daniel Hoyer, László Hunyady, Ahsan Husain, Adriaan P. IJzerman, Tadashi Inagami, Kenneth A. Jacobson, Robert T. Jensen, Ralf Jockers, Deepa Jonnalagadda, Sadashiva Karnik, Klemens Kaupmann, Jacqueline Kemp, Charles Kennedy, Yasuyuki Kihara, Takio Kitazawa, Pawel Kozielewicz, Hans‐Jürgen Kreienkamp, Jyrki P. Kukkonen, Tobias Langenhan, Dan Larhammar, Katie Leach, Davide Lecca, John D. Lee, Susan E. Leeman, Jérôme Leprince, Xaria X. Li, Stephen J. Lolait, Amelie Lupp, Robyn Macrae, Janet Maguire, Davide Malfacini, Jean Mazella, Craig A. McArdle, Shlomo Melmed, Martin C. Michel, Laurence J. Miller, Vincenzo Mitolo, Bernard Mouillac, Christa E. Müller, Philip M. Murphy, Jean‐Louis Nahon, Tony Ngo, Xavier Norel, Duuamene Nyimanu, Anne‐Marie O’Carroll, Stefan Offermanns, Maria Antonietta Panaro, Marc Parmentier, Roger G. Pertwee, Jean‐Philippe Pin, Eric R. Prossnitz, Mark Quinn, Rithwik Ramachandran, Manisha Ray, Rainer K. Reinscheid, Philippe Rondard, G. Enrico Rovati, Chiara Ruzza, Gareth J. Sanger, Torsten Schöneberg, Gunnar Schulte, Stefan Schulz, Deborah L. Segaloff, Charles N. Serhan, Khuraijam Dhanachandra Singh, Craig M. Smith, Leigh A. Stoddart, Yukihiko Sugimoto, Roger Summers, Valerie P. Tan, David Thal, Walter ( Wally) Thomas, Pieter B. M. W. M. Timmermans, Kalyan Tirupula, Lawrence Toll, Giovanni Tulipano, Hamiyet Unal, Thomas Unger, Celine Valant, Patrick Vanderheyden, David Vaudry, Hubert Vaudry, Jean‐Pierre Vilardaga, Christopher S. Walker, Ji Ming Wang, Donald T. Ward, Hans‐Jürgen Wester, Gary B. Willars, Tom Lloyd Williams, Trent M. Woodruff, Chengcan Yao, Richard D. Ye   +165 more
wiley   +1 more source

Microbiota‐related metabolites fueling the understanding of ischemic heart disease

iMeta, Volume 2, Issue 2, May 2023., 2023
Up‐to‐date knowledge of gut microbial taxa associated with ischemic heart disease (IHD). Microbial metabolites for mechanistic dissection of IHD pathology. Microbiome‐based therapies in IHD prevention and treatment.
Yong Fan, Jiajun Ying, Hongchuang Ma, Hanbin Cui   +3 more
wiley   +1 more source

Structural and functional evolution of the trace amine-associated receptors TAAR3, TAAR4 and TAAR5 in primates. [PDF]

PLoS ONE, 2010
The family of trace amine-associated receptors (TAAR) comprises 9 mammalian TAAR subtypes, with intact gene and pseudogene numbers differing considerably even between closely related species.
Claudia Stäubert, Iris Böselt, Jens Bohnekamp, Holger Römpler, Wolfgang Enard, Torsten Schöneberg   +5 more
doaj   +1 more source

Up‐regulated SAMD9L modulated by TLR2 and HIF‐1α as a promising biomarker in tuberculosis

Journal of Cellular and Molecular Medicine, Volume 26, Issue 10, Page 2935-2946, May 2022., 2022
Abstract The aim of this study was to identify potential biomarkers of TB in blood and determine their function in Mtb‐infected macrophages. First of all, WGCNA was used to analyse 9451 genes with significant changes in TB patients’ whole blood. The 220 interferon‐γ‐related genes were identified, and then 30 key genes were screened using Cytoscape ...
Xiang‐juan Zhang, Hai‐shan Xu, Chong‐hui Li, Yu‐rong Fu, Zheng‐jun Yi   +4 more
wiley   +1 more source

Multiple types of genomic variation contribute to adaptive traits in the mustelid subfamily Guloninae

Molecular Ecology, Volume 31, Issue 10, Page 2898-2919, May 2022., 2022
Abstract Species of the mustelid subfamily Guloninae inhabit diverse habitats on multiple continents, and occupy a variety of ecological niches. They differ in feeding ecologies, reproductive strategies and morphological adaptations. To identify candidate loci associated with adaptations to their respective environments, we generated a de novo assembly
Lorena Derežanin, Asta Blažytė, Pavel Dobrynin, David A. Duchêne, José Horacio Grau, Sungwon Jeon, Sergei Kliver, Klaus‐Peter Koepfli, Dorina Meneghini, Michaela Preick, Andrey Tomarovsky, Azamat Totikov, Jörns Fickel, Daniel W. Förster   +13 more
wiley   +1 more source