TAAR8 in the Brain: Implications for Dopaminergic Function, Neurogenesis, and Behavior [PDF]
BiomedicinesBackground/Objectives: G protein-coupled trace amine-associated receptors (TAARs) belong to a family of biogenic amine-sensing receptors. TAAR1 is the best-investigated receptor of this family, and TAAR1 agonists are already being tested in clinical ...
Taisiia S. Shemiakova +7 more
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TAAR8 Mediates Increased Migrasome Formation by Cadaverine in RPE Cells [PDF]
Current Issues in Molecular BiologyMigrasomes, the newly discovered cellular organelles that form large vesicle-like structures on the retraction fibers of migrating cells, are thought to be involved in communication between neighboring cells, cellular content transfer, unwanted material ...
Joon Bum Kim +9 more
doaj +7 more sources
Deregulation of Trace Amine-Associated Receptors (TAAR) Expression and Signaling Mode in Melanoma [PDF]
Biomolecules, 2022 Trace amine-associated receptors (TAARs) interact with amine compounds called “trace amines” which are present in tissues at low concentrations. Recently, TAARs expression in neoplastic tumors was reported. In this study, TAARs expression was analyzed in
Anastasia N. Vaganova +3 more
doaj +5 more sources
Analysis of Human TAAR8 and Murine Taar8b Mediated Signaling Pathways and Expression Profile [PDF]
International Journal of Molecular Sciences, 2014 The thyroid hormone derivative 3-iodothyronamine (3-T1AM) exerts metabolic effects in vivo that contradict known effects of thyroid hormones. 3-T1AM acts as a trace amine-associated receptor 1 (TAAR1) agonist and activates Gs signaling in vitro. Interestingly, 3-T1AM-meditated in vivo effects persist in Taar1 knockout-mice indicating that further ...
Heike Biebermann +2 more
exaly +9 more sources
Trace Amine-Associated Receptors and Monoamine-Mediated Regulation of Insulin Secretion in Pancreatic Islets [PDF]
Biomolecules, 2023 Currently, metabolic syndrome treatment includes predominantly pharmacological symptom relief and complex lifestyle changes. Trace amines and their receptor systems modulate signaling pathways of dopamine, norepinephrine, and serotonin, which are ...
Anastasia N. Vaganova +5 more
doaj +5 more sources
The Expression of Trace Amine-Associated Receptors (TAARs) in Breast Cancer Is Coincident with the Expression of Neuroactive Ligand–Receptor Systems and Depends on Tumor Intrinsic Subtype [PDF]
Biomolecules, 2023 Currently, the contribution of trace amine-associated receptors (TAARs) to breast cancer (BC) is recognized, but their associations with various pathological characteristics are not yet understood.
Anastasia N. Vaganova +4 more
doaj +5 more sources
Identifying human diamine sensors for death related putrescine and cadaverine molecules. [PDF]
PLoS Computational Biology, 2018 Pungent chemical compounds originating from decaying tissue are strong drivers of animal behavior. Two of the best-characterized death smell components are putrescine (PUT) and cadaverine (CAD), foul-smelling molecules produced by decarboxylation of ...
Cristina Izquierdo +4 more
doaj +6 more sources
Trace Amine-Associated Receptors’ Role in Immune System Functions [PDF]
BiomedicinesTrace amines are a separate, independent group of biogenic amines, close in structure to classical monoamine neurotransmitters such as dopamine, serotonin, and norepinephrine that include many products of the endogenous or bacteria-mediated ...
Vyacheslav I. Moiseenko +3 more
doaj +5 more sources
TAARs as Novel Therapeutic Targets for the Treatment of Depression: A Narrative Review of the Interconnection with Monoamines and Adult Neurogenesis [PDF]
BiomedicinesDepression is a common mental illness of great concern. Current therapy for depression is only suitable for 80% of patients and is often associated with unwanted side effects.
Taisiia S. Shemiakova +2 more
doaj +5 more sources
Expression of Trace Amine-Associated Receptors in the Murine and Human Hippocampus Based on Public Transcriptomic Data [PDF]
Cells, 2022 Hippocampus is one of the neurogenic zones where adult neurogenesis takes place. This process is quite complex and has a multicomponent regulation. A family of G protein-coupled trace amine-associated receptors (TAARs) was discovered only in 2001, and ...
Nataliia V. Katolikova +3 more
doaj +4 more sources