The dark sides of the GPCR tree ‐ research progress on understudied GPCRs
British Journal of Pharmacology, Volume 182, Issue 14, Page 3109-3134, July 2025.Abstract A large portion of the human GPCRome is still in the dark and understudied, consisting even of entire subfamilies of GPCRs such as odorant receptors, class A and C orphans, adhesion GPCRs, Frizzleds and taste receptors. However, it is undeniable that these GPCRs bring an untapped therapeutic potential that should be explored further.
Magdalena M. Scharf +10 more
wiley +1 more source
, 2016 The ligand of the β1AR, dobutamine, is shown with the stick model. Positively selected sites are indicated by red (detected by the site model in TAAR7), green (detected by the branch-site model in flying fox TAAR7c and elephant TAAR7a), purple (detected ...
Federico G. Hoffmann (367043) +3 more
core +1 more source
Recent Advances in Mammalian Olfactory Receptor Function and Structure
Sensory Neuroscience, Volume 1, Issue 1, April 2025.Olfactory receptors (ORs), a subset of G protein‐coupled receptors (GPCRs), mediate odor detection in sensory neurons and regulate diverse physiological functions across tissues. Their roles in metabolism, immunity, and neural processes underscore their therapeutic relevance. Recent high‐resolution Cryo‐EM studies have unveiled OR activation mechanisms,
Hongxi Qin +9 more
wiley +1 more source
Identification of candidate G protein coupled receptors : role of purinergic receptor P2Y2 in pulmonary arterial hypertension [PDF]
, 2017 Idiopathic pulmonary arterial hypertension is a progressive, chronic, and usually lethal lung disease of unknown causes with limited therapeutic options. Pulmonary arterial hypertension is characterized by aberrant pulmonary vasoconstriction and abnormal
Viswanathan, Gayathri
core +1 more source
Espressione dei recettori TAARs (trace amine-associated receptors) nella mucosa nasale umana [PDF]
, 2011 I trace amine associated receptors (TAARs) sono stati identificati recentemente nel neuroepitelio olfattorio (EO) di topo e si pensa possano essere implicati nella detezione delle amine volatili, inclusi i ferormoni. Scopo di questo studio è stato quello
SANTORO, AMELIA
core
, 2012 3-Iodothyronamine (T1AM) is a novel chemical messenger, structurally related to thyroid hormone, able to interact with G protein-coupled receptors known as trace amine-associated receptors (TAARs). Little is known about the physiological role of T1AM. In
GHELARDONI, SANDRA +7 more
core
Distribution of 3-iodothyronamine and trace amine-associated receptors in mouse
, 2011 interact with specific G protein-coupled receptors, known as trace amine-associated receptors (TAAR). Metabolic, endocrine and cardiac effects of exogenous T1AM have been reported.
GHELARDONI, SANDRA +5 more
core
Search for Structural Basis of Interactions of Biogenic Amines with Human TAAR1 and TAAR6 Receptors. [PDF]
Int J Mol Sci, 2021 Glyakina AV +5 more
europepmc +1 more source
Trace amine-associated receptors at the cross-road between innate olfaction of amines, emotions, and adult neurogenesis. [PDF]
Neural Regen Res, 2022 Efimova EV +3 more
europepmc +1 more source
Evolution of Brain-Expressed Biogenic Amine Receptors into Olfactory Trace Amine-Associated Receptors. [PDF]
Mol Biol Evol, 2022 Guo L +9 more
europepmc +1 more source