Unlocking the Therapeutic Potential of Ulotaront as a Trace Amine-Associated Receptor 1 Agonist for Neuropsychiatric Disorders [PDF]
Biomedicines, 2023 All antipsychotics currently used in clinic block D2 dopamine receptors. Trace amine-associated receptor 1 is emerging as a new therapeutic target for schizophrenia and several other neuropsychiatric disorders.
Savelii R. Kuvarzin +4 more
doaj +5 more sources
Trace Amines and the Trace Amine-Associated Receptor 1: Pharmacology, Neurochemistry and Clinical Implications [PDF]
Frontiers in Neuroscience, 2016 Biogenic amines are a collection of endogenous molecules that play pivotal roles as neurotransmitters and hormones. In addition to the classical biogenic amines resulting from decarboxylation of aromatic acids, including dopamine (DA), norepinephrine ...
Yue ePei +2 more
doaj +14 more sources
Molecular basis of human trace amine-associated receptor 1 activation [PDF]
Nature Communications, 2023 The human trace amine-associated receptor 1 (hTAAR1, hTA1) is a key regulator of monoaminergic neurotransmission and the actions of psychostimulants. Despite preclinical research demonstrating its tractability as a drug target, its molecular mechanisms ...
Gregory Zilberg +4 more
doaj +5 more sources
Trace amine-associated receptors and their ligands [PDF]
British Journal of Pharmacology, 2006 Classical biogenic amines (adrenaline, noradrenaline, dopamine, serotonin and histamine) interact with specific families of G protein‐coupled receptors (GPCRs). The term ‘trace amines’ is used when referring top‐tyramine, β‐phenylethylamine, tryptamine and octopamine, compounds that are present in mammalian tissues at very low (nanomolar ...
David K. Grandy, T S Scanlan
exaly +4 more sources
Gut Microbiota Alterations in Trace Amine-Associated Receptor 9 (TAAR9) Knockout Rats [PDF]
Biomolecules, 2022 Trace amine-associated receptors (TAAR1-TAAR9) are a family of G-protein-coupled monoaminergic receptors which might have great pharmacological potential.
Ilya S. Zhukov +5 more
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Trace amine-associated receptor 1 and drug abuse. [PDF]
Adv Pharmacol, 2022 Trace amine-associated receptor 1 (TAAR1) is the best characterized receptor selectively activated by trace amines. It is broadly expressed in the monoaminergic system in the brain including ventral tegmental area (VTA), nucleus accumbens (NAc), dorsal raphe (DR) and substantial nigra (SN). Extensive studies have suggested that TAAR1 plays an important
Wu R, Liu J, Li JX.
europepmc +3 more sources
Exploring Consequences of Predator Stress on Behaviors of Mice Lacking Trace Amine-Associated Receptor 5 (TAAR5) [PDF]
CellsRecent studies indicated a connection between trace amine-associated receptor 5 (TAAR5) and emotional behaviors related to anxiety and depression; however, the neurobiological basis of this link is still unclear.
Vsevolod V. Nemets +4 more
doaj +2 more sources
Trace Amine-Associated Receptor 1 Trafficking to Cilia of Thyroid Epithelial Cells [PDF]
Cells, 2021 Trace amine-associated receptor 1 (rodent Taar1/human TAAR1) is a G protein-coupled receptor that is mainly recognized for its functions in neuromodulation.
Maria Qatato +8 more
doaj +2 more sources
Role of the trace amine associated receptor 5 (TAAR5) in the sensorimotor functions [PDF]
Scientific Reports, 2021 Classical monoamines are well-known modulators of sensorimotor neural networks. However, the role of trace amines and their receptors in sensorimotor function remains unexplored.
D. S. Kalinina +11 more
doaj +2 more sources
Human trace amine-associated receptor TAAR5 can be activated by trimethylamine. [PDF]
PLoS ONE, 2013 In addition to the canonical olfactory receptors, TAARs were currently suggested to be a second class of chemosensory receptors in the olfactory epithelium of vertebrates.
Ivonne Wallrabenstein +10 more
doaj +5 more sources